Purification and Characterization of a Phospholipase A2 from Human Osteoarthritic Synovial Fluid

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Intracellular phospholipases A

1980 • 989 citations

Structure and Properties of a Human Non-pancreatic Phospholipase A2

1989 • 668 citations

Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid

1989 • 542 citations

Structure and function of phospholiphase A2

1981 • 478 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants.

1977 • 406 citations

A model to explain the pharmacological effects of snake venom phospholipases A2

1989 • 404 citations

Role of secretory phospholipases A2 in the pathobiology of disease.

1986 • 382 citations

1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

1984 • 296 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine by rat alveolar macrophages. Phospholipase A2 and acetyltransferase activities during phagocytosis and ionophore stimulation.

1983 • 266 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Animal, Plant, and Microbial Toxins

1976 • 209 citations

Phospholipase A2 activity in sera and synovial fluids in rheumatoid arthritis and osteoarthritis. Its possible role as a proinflammatory enzyme.

1985 • 185 citations

Purification and Characterization of Extracellular Phospholipase A2 from Human Synovial Fluid in Rheumatoid Arthritis1

1989 • 166 citations

The lysine-49 phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. Relation of structure and function to other phospholipases A2.

1986 • 159 citations

Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid

1988 • 152 citations

Purification and Characterization of Phospholipase A2 Released from Rat Platelets

1987 • 147 citations

Phospholipases and phospholipid turnover in Escherichia coli spheroplasts

1972 • 139 citations

A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine

1986 • 137 citations

Identification and isolation of a mammalian protein which is antigenically and functionally related to the phospholipase A2 stimulatory peptide melittin.

1987 • 136 citations

Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

1986 • 134 citations

Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.

1988 • 128 citations

Pathogenesis of hypotension in septic shock

1988 • 124 citations

Rattlesnake presynaptic neurotoxins: primary structure and evolutionary origin of the acidic subunit

1985 • 115 citations

Purification and Characterization of Extracellular Phospholipase A2 from Peritoneal Cavity of Caseinate-Treated Rat1

1987 • 114 citations

Novel intestinal phospholipase A2: purification and some molecular characteristics

1982 • 113 citations

Characterization of extracellular phospholipase A2 in rheumatoid synovial fluid

1985 • 110 citations

The proinflammatory effect of intra-articular injection of soluble human and venom phospholipase A2.

1989 • 107 citations

Immunoaffinity purification, partial sequence, and subcellular localization of rat liver phospholipase A2

1989 • 107 citations

What is the relationship between enzymatic activity and pharmacological properties of phospholipases in natural poisons?

1985 • 102 citations

A complete amino acid sequence for the basic subunit of crotoxin

1986 • 94 citations

Solubilization and properties of Ca2+-dependent human platelet phospholipase A2

1986 • 94 citations

Therapeutic approaches to inflammatory diseases

1990 • 90 citations

Enzymatic characteristics of crotalus phospholipase A2 and the crotoxin complex

1976 • 88 citations

Serum phospholipase A2 correlates with disease activity in rheumatoid arthritis.

1988 • 87 citations

Purification of Rabbit Platelet Secretory Phospholipase A2 and Its Characteristics1

1989 • 87 citations

Involvement of circulating phospholipase A₂ in the pathogenesis of the hemodynamic changes in endotoxin shock

1983 • 86 citations

Purification of a Soluble Phospholipase A2 from Synovial Fluid in Rheumatoid Arthritis1

1986 • 86 citations

A phospholipase A₂ hydrolyzing arachidonoyl‐phospholipids in mouse peritonea macrophages

1989 • 84 citations

The chemical basis for interfacial activation of monomeric phospholipases A2. Autocatalytic derivatization of the enzyme by acyl transfer from substrate.

1988 • 84 citations

Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2

1988 • 83 citations

The primary structure of a membrane-associated phospholipase A2 from human spleen

1989 • 74 citations

Stimulated platelets release equivalent amounts of arachidonate from phosphatidylcholine, phosphatidylethanolamine, and inositides.

1988 • 66 citations

Phospholipase A2 from human synovial fluid: Purification and structural homology to the placental enzyme

1988 • 63 citations

Amino Acid Composition and NH2-Terminal Amino Acid Sequence of Human Phospholipase A2 Purified from Rheumatoid Synovial Fluid1

1988 • 61 citations

Multiple Forms of Phospholipase A2 in Arthritic Synovial Fluid

1989 • 59 citations

Amino acid sequence of a basic Agkistrodon halys blomhoffii phospholipase A2. Possible role of amino-terminal lysines in action on phospholipids of Escherichia coli

1986 • 50 citations

Amino Acid Composition and NH2-Terminal Amino Acid Sequence of Rat Platelet Secretory Phospholipase A21

1987 • 41 citations

Acylchain Specificity and Kinetic Properties of Phospholipase A₁ and A₂ of Bone Marrow-Derived Macrophages

1985 • 37 citations

Detection in Human Platelets of Phospholipase A2 Activity Which Preferentially Hydrolyzes an Arachidonoyl Residue1

1988 • 33 citations

Amino Acid Sequence of Trimeresurus flavoviridis Phospholipase A2

1986 • 33 citations

The role of intramembrane Ca2+ in the hydrolysis of the phospholipids of Escherichia coli by Ca2+-dependent phospholipases.

1985 • 31 citations

Relation between binding and the action of phospholipases A2 on Escherichia coli exposed to the bactericidal/permeability-increasing protein of neutrophils

1987 • 27 citations

Modulation of phospholipase A2 activity in human synovial fluid by cations

1987 • 19 citations

Crotoxin: A Biochemical Analysis of Its Mode of Action

1986 • 17 citations

Revised Amino Acid Sequence, Crystallization, and Preliminary X-ray Diffraction Analysis of Acidic Phospholipase A2 from the Venom of Agkistrodon Halys blomhoffii

1989 • 16 citations

Characterization of human placental blood vessel phospholipase a2, demonstration of substrate selectivity for arachidonyl-phosphatidylcholine

1985 • 9 citations

Purification and characterization of a membrane-associated phospholipase A[2] from rat spleen

1988 • 8 citations