18O and Related Exchanges in Enzymic Formation and Utilization of Nucleoside Triphosphates1 1Preparation of the review and unpublished work mentioned herein was supported in part by Grant No. GM-11094 of the Institute of General Medical Sciences of the U.S. Public Health Service and by Contract AT(11–1)34 of the U.S. Atomic Energy Commission.

Personal Communication

2014 • 3,860 citations

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2022 • 1,326 citations

Photophosphorylation by swiss-chard chloroplasts

1960 • 846 citations

Further investigations on a Mg++ + Na+-activated adenosintriphosphatase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane

1960 • 799 citations

Regulation of Enzyme Activity

1966 • 612 citations

ATP formation caused by acid-base transition of spinach chloroplasts.

1966 • 493 citations

Table of Isotopes

1953 • 485 citations

Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

1960 • 378 citations

Partial Resolution of the Enzymes Catalyzing Photophosphorylation

1965 • 369 citations

Enzyme Kinetics

1967 • 368 citations

Pyruvate Carboxylase

1963 • 324 citations

Differential Effects of Rotenone and Amytal on Mitochondrial Electron and Energy Transfer

1963 • 318 citations

COFACTORS AND RATES OF PHOTOSYNTHETIC PHOSPHORYLATION BY SPINACH CHLOROPLASTS

1958 • 284 citations

Antibiotics as Tools for Metabolic Studies. II. Inhibition of Phosphoryl Transfer in Mitochondria by Oligomycin and Aurovertin^*

1964 • 279 citations

Biological Oxidoreductions

1964 • 221 citations

LIGHT INDUCED PHOSPHORYLATION BY CELL-FREE PREPARATIONS OF PHOTOSYNTHETIC BACTERIA¹

1954 • 214 citations

Stability Constants of Metal Complexes with Mononucleotides.

1958 • 214 citations

Pyruvate Carboxylase

1965 • 209 citations

Photosynthesis by Isolated Chloroplasts. II. Photosynthetic Phosphorylation, the Conversion of Light into Phosphate Bond Energy

1954 • 193 citations

A method of analysis of oxygen isotopes in orthophosphate—its use in the measurement of paleotemperatures

1960 • 191 citations

Erythrocytic Nucleoside Diphosphokinase

1966 • 190 citations

Oxygen Exchange as Evidence for the Existence of an Intermediate in Ester Hydrolysis

1951 • 190 citations

Uses and limitations of measurements of rates of isotopic exchange and incorporation in catalyzed reactions

1959 • 182 citations

The Lanthanum Hydroxide Gel Promoted Hydrolysis of Phosphate Esters

1955 • 181 citations

Isotope Exchange Studies of the Mechanism of the Reaction Catalyzed by Adenosine Triphosphate: Creatine Phosphotransferase

1966 • 176 citations

OXIDATIVE PHOSPHORYLATION BY AN ENZYME COMPLEX FROM EXTRACTS OF MITOCHONDRIA

1957 • 163 citations

Studies on the Mechanism of Glutamine Synthesis: Evidence for the Formation of Enzyme-bound Activated Glutamic Acid

1962 • 161 citations

A STUDY OF OXIDATIVE PHOSPHORYLATION WITH O18-LABELED INORGANIC PHOSPHATE

1953 • 151 citations

ABSORPTION OF SUGARS IN VITRO BY THE INTESTINE OF THE GOLDEN HAMSTER

1955 • 146 citations

Liver Microsomal Glucose 6-Phosphatase, Inorganic Pyrophosphatase, and Pyrophosphate-Glucose Phosphotransferase

1965 • 137 citations

A method for oxygen isotope analysis of milligram quantities of water and some of its applications

1966 • 135 citations

Studies on the Hydrolysis of Adenosine Triphosphate by Spinach Chloroplasts

1965 • 132 citations

Metabolism of Inorganic Pyrophosphate

1964 • 129 citations

Mechanism of the Aldolase Reaction

1965 • 128 citations

The Adenosine Triphosphate-Adenosine Diphosphate Exchange Reaction of Oxidative Phosphorylation

1958 • 127 citations

O18 AND P32 EXCHANGE REACTIONS OF MITOCHONDRIA IN RELATION TO OXIDATIVE PHOSPHORYLATION

1956 • 122 citations

Reversal and Mechanism of Oxidative Phosphorylation

1954 • 121 citations

A STUDY WITH O18 OF ADENOSINE TRIPHOSPHATE FORMATION IN OXIDATIVE PHOSPHORYLATION

1955 • 118 citations

STUDIES ON THE MECHANISM OF THE REACTION CATALYZED BY THE PHOSPHORYLATING ENZYME

1955 • 115 citations

Pyruvate Carboxylase

1965 • 114 citations

Equilibrium Reaction Rates and the Mechanisms of Liver and Yeast Alcohol Dehydrogenase

1964 • 110 citations

Simple procedure for conversion of oxygen of orthophosphate or water to carbon dioxide for oxygen-18 determination

1961 • 109 citations

Studies on the relation of the adenosinetriphosphate-inorganic phosphate exchange reaction of mitochondria to oxidative phosphorylation

1958 • 104 citations

PHOSPHATE-WATER EXCHANGE REACTION CATALYZED BY INORGANIC PYROPHOSPHATASE OF YEAST

1958 • 99 citations

STUDIES ON THE MECHANISM OF ACTION OF GLUTATHIONE SYNTHETASE

1955 • 95 citations

Mechanism of Hydrolysis of Adenosinetriphosphate by Muscle Proteins and Its Relation to Muscular Contraction

1959 • 94 citations

Oxidative Phosphorylation

1962 • 93 citations

The Enzymatic Activity and Inhibition of Adenosine 5′-Triphosphate-Creatine Transphosphorylase

1960 • 92 citations

The Enzymatic Carboxylation of Phosphoenolpyruvate

1966 • 92 citations

Oxygen Isotope Exchange Reactions of Organic Compounds

1965 • 91 citations

Equilibrium and Net Reaction Rates in Relation to the Mechanism of Yeast Hexokinase

1964 • 90 citations

Detection of bound phosphohistidine in E. coli succinate thiokinase

1964 • 89 citations

Thermodynamic Study of an Enzyme—Substrate Complex of Chymotrypsin. I^1,2

1952 • 86 citations

Bacterial photophosphorylation in the absence of added nucleotide. A second intermediate stage of energy transfer in light-induced formation of ATP

1966 • 86 citations

Equilibrium Reaction Rates and the Mechanisms of Bovine Heart and Rabbit Muscle Lactate Dehydrogenases

1964 • 84 citations

The relation of the light-dependent and light-triggered adenosine triphosphatases to photophosphorylation

1965 • 83 citations

Mechanism of action of alkaline phosphatase

1952 • 83 citations

Direct Oxygen Transfer in Enzymic Syntheses Coupled to Adenosine Triphosphate Degradation¹

1956 • 82 citations

THE MECHANISM OF ENZYMIC PHOSPHATE TRANSFER REACTIONS

1955 • 82 citations

STUDIES WITH BACTERIAL SUCROSE PHOSPHORYLASE

1947 • 81 citations

Distribution of an Oligomycin-sensitive Adenosine Triphosphate-Adenosine Diphosphate Exchange Reaction and Its Relationship to the Respiratory Chain

1963 • 80 citations

THE EFFECT OF AZIDE ON PHOSPHORYLATION ACCOMPANYING ELECTRON TRANSPORT AND GLYCOLYSIS

1955 • 78 citations

Kinetic studies on the reaction catalyzed by phosphoglycerate kinase

1967 • 73 citations

Equilibrium Reaction Rates and Enzyme Mechanisms.

1963 • 70 citations

The association of readily-soluble bound phosphohistidine from mitochondria with succinate thiokinase

1964 • 70 citations

Detection of phosphohistidine in nucleoside diphosphokinase isolated from Jerusalem artichoke mitochondria

1965 • 68 citations

Effect of 2:4-dinitrophenol and phenylmercuric acetate on enzymic activity of myosin

1955 • 68 citations

TRANSFER OF OXYGEN IN THE GLUTAMINE SYNTHETASE REACTION

1956 • 67 citations

The stimulation of the adenosinetriphosphatase activities of myofibrils and l-myosin by 2:4-dinitrophenol

1955 • 65 citations

Studies on the Enzymatic Synthesis of Glutamine

1955 • 63 citations

The Natural History of Oxygen

1965 • 63 citations

Light-dependent Adenosine Triphosphatase in Chloroplasts

1962 • 63 citations

The concept and use of flux measurements in enzyme studies

1966 • 61 citations

Studies on the non-oxidative exchange between inorganic phosphate and ATP, as catalyzed by intact mitochondria

1956 • 57 citations

Carbonyl Oxygen Exchange in General Base Catalyzed Ester Hydrolysis

1967 • 57 citations

Die erhöhung der rate der ATP-spaltung durch myosin- und actomyosin-gele bei beginn der spaltung

1954 • 57 citations

The Oxidation State of the Respiratory Carriers and the Partial Reactions of Oxidation Phosphorylation

1959 • 55 citations

MECHANISM OF ENZYME ACTION

1960 • 54 citations

Direct and ¹⁸O-Exchange Measurements Relevant to Possible Activated or Phosphorylated States of Myosin^*

1966 • 54 citations

Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

1965 • 54 citations

Properties of the O18 Exchange Reaction Catalyzed by Heavy Meromyosin

1963 • 52 citations

Evidence for the point of action of 2,4-dinitrophenol on ATPase, ATP−32P exchange, ATP-AD32P exchange and phosphorylation

1958 • 52 citations

A Kinetic Study of Carbamyl Phosphate Synthetase

1964 • 52 citations

Evidence for Succinyl Phosphate as an Enzyme-bound Intermediate in the Reaction Catalyzed by Succinyl Coenzyme A Synthetase^*

1965 • 51 citations

On the Mode of Action of 2,4-Dinitrophenol in Uncoupling Oxidative Phosphorylation

1958 • 48 citations

An Enzyme System from Mitochondria Catalyzing Adenosine Diphosphate-Adenosine Triphosphate and Orthophosphate-Adenosine Triphosphate Exchange Reactions

1959 • 47 citations

The Apparent Independence of the Phosphorylation and Water Formation Reactions from the Oxidation Reactions of Oxidative Phosphorylation

1966 • 46 citations

NDP kinase: Demonstration of phosphorylated enzyme as the reactive intermediate

1965 • 46 citations

Mechanistic Implications of Mg++, Adenine Nucleotide, and Inhibitor Effects on Energy-linked Reactions of Submitochondrial Particles

1967 • 45 citations

The Addition and Release of Magnesium in the Phosphoglucomutase Reaction

1966 • 44 citations

Formyltetrahydrofolate Synthetase

1962 • 44 citations

The Purification and Mechanism of Action of Yeast Phosphoglucomutase

1959 • 44 citations

Studies on Adenosine Triphosphate: Arginine Phosphotransferase

1966 • 43 citations

The nature and action of mitochrome

1958 • 43 citations

On the Mechanism of Formation of Isopentenylpyrophosphate^*

1962 • 41 citations

Studies on Possible Phosphoryl Enzyme Formation in Catalysis by Hexokinase, Pyruvate Kinase, and Glucose 6-Phosphatase

1961 • 39 citations

Kinetic Analysis of the Reaction of Cytochrome cc' with Carbon Monoxide

1966 • 39 citations

The relation of the adenosine 5′-triphosphate-adenosine 5′-diphosphate exchange activity to photophosphorylation in swiss-chard chloroplasts

1964 • 38 citations

Some Properties of γ-Glutamylcysteine Synthetase

1960 • 38 citations

The Phosphate-Water Oxygen Exchange Reaction of Oxidative Phosphorylation in Submitochondrial Preparations

1960 • 38 citations

MECHANISM OF HYDROLYSIS OF ADENOSINETRIPHOSPHATE CATALYZED BY PURIFIED MUSCLE PROTEINS

1954 • 37 citations

Pepsin-catalyzed exchange of oxygen atoms between water and carboxylic acids

1962 • 37 citations

Properties of the Inorganic Orthophosphate-Adenosine Triphosphate and Adenosine Diphosphate-Adenosine Triphosphate Exchange Reactions of Digitonin Particles

1961 • 36 citations

Chemical physiology of contraction in body and heart muscle

1954 • 36 citations

A light-triggered ATP-Pi exchange activity in chloroplasts

1966 • 36 citations

Transfer of O18 in Arsenolysis Reactions

1960 • 35 citations

Characteristics of an Orthophosphate Oxygen Exchange Catalyzed by Myosin, Actomyosin, and Muscle Fibers

1963 • 35 citations

Properties of an Oligomycin-sensitive Adenosine Diphosphate-Adenosine Triphosphate Exchange Reaction in Intact Beef Heart Mitochondria

1966 • 35 citations

Adenosine Triphosphatase Activity in Chloroplasts.

1960 • 35 citations

Properties of the Active Site in Myosin Hydrolysis of Adenosine Triphosphate as Indicated by the O18-Exchange Reaction

1960 • 35 citations

Ionic requirements for oxidative phosphorylation, ATP-32P exchange and ATPase

1957 • 33 citations

Enzyme-catalyzed Exchange of Oxygen Atoms between Water and Carboxylate Ion¹

1954 • 33 citations

Enzymatic and Mechanical Properties of Muscle Proteins.

1942 • 32 citations

Oxidative phosphorylation in stable sonic fragments of rat-liver mitochondria

1963 • 32 citations

Isolation of a phosphorylated intermediate involved in the ADP-ATP exchange reaction

1966 • 31 citations

Relation between electron flow phosphorylation, and a high energy state of chloroplasts

1965 • 30 citations

The Adenosine Triphosphate-Adenosine Diphosphate Exchange Reaction of Intact Rat Liver Mitochondria

1961 • 30 citations

Ca++ and Pi uptake by non-phosphorylating mitochondrial preparations

1964 • 29 citations

The Action of Oligomycin on the Inorganic Orthophosphate-Adenosine Triphosphate and Adenosine Diphosphate-Adenosine Triphosphate Exchange Reactions of Digitonin Particles

1962 • 28 citations

The Fate of Phosphate Oxygen in Photophosphorylation

1965 • 28 citations

A study of photophosphorylation with oxygen-18

1960 • 28 citations

The Infrared Absorption Spectrum of Oxygen-18-Labeled Glycine

1966 • 27 citations

Substrate Interchanges and Oxygen Transfers Catalyzed by Glutamine Synthetase at Equilibrium^*

1962 • 27 citations

The Exchange of Oxygen between Phosphoric Acid and Water¹

1958 • 27 citations

The Hydrolysis of Glucose 6-Phosphate^1,2

1966 • 27 citations

STUDIES ON THE INHIBITION OF THE MITOCHONDRIAL ATP-ase BY REDUCTION OF THE RESPIRATORY CHAIN

1960 • 26 citations

Adenosine monophosphate as the first phosphoryl acceptor in oxidative phosphorylation

1966 • 26 citations

EVIDENCE FOR AN INTERMEDIATE IN THE HYDROLYSIS OF ATP BY MUSCLE PROTEINS

1958 • 26 citations

Multiple Intermediates in Steady-state Enzyme Kinetics. IV. The Steady State Kinetics of Isotopic Exchange in Enzyme-catalyzed Reactions

1962 • 26 citations

Method for Determination of Oxygen-18 Content of Inorganic Phosphate

1958 • 25 citations

The Transfer of Oxygen from Arsenate-18O to Phosphate in Arsenate-stimulated Adenosine Triphosphatase Reactions

1963 • 25 citations

COMPARTMENTATION OF THE MITOCHONDRION

1965 • 25 citations

Isotopic Exchange at Equilibrium as A Criterion of Enzymatic Mechanisms

1964 • 24 citations

Effect of Adenosine Diphosphate on the Exchange of Oxygen between Inorganic Phosphate and Water Catalyzed by Digitonin Particles^*

1965 • 23 citations

Catalysis of an Inorganic Phosphate-H2O18 Exchange by Actomyosin and Myosin

1961 • 21 citations

The effect of long-chain fatty acids on orthophosphate-adenosine 5′-triphosphate exchange activity associated with oxidative phosphorylation

1965 • 21 citations

The Biochemistry of Muscle

1964 • 21 citations

318. The reactions of organic phosphates. Part IV. Oxygen exchange between water and orthophosphoric acid

1961 • 21 citations

Glucose-6-Phosphatase and the Exchange of Glucose with Glucose-6-Phosphate

1960 • 20 citations

The distribution of tracer substrate in an enzyme-substrate system at equilibrium

1962 • 20 citations

An Enzyme from Spinach Chloroplasts Catalyzing Adenosine Triphosphate-Adenosine Diphosphate Exchange

1961 • 18 citations

PHOSPHATE TRANSFER CATALYZED BY PHOSPHOGLYCERIC ACID MUTASE

1957 • 17 citations

Further Evidence for Oxygen Exchange at an Intermediate Stage in Myosin Hydrolysis

1962 • 17 citations

The fate of oxygens of inorganic phosphate in photophosphorylation

1961 • 16 citations

Formyltetrahydrofolate synthetase

1964 • 15 citations

Pathway of ATP formation in photosynthetic phosphorylation

1960 • 15 citations

Catalysis of an oxygen exchange reaction between long-chain fatty acids and water by rat-liver mitochondria

1965 • 15 citations

The Occurrence of a Glucose-Enzyme Complex in the Reaction Catalyzed by Sucrose Phosphorylase

1966 • 14 citations

Mechanism of Hydrolysis of Adenosine Triphosphate catalysed by Lobster Muscle

1953 • 14 citations

Enzymatic Modification of Myosin by Disulfide Exchange^*

1965 • 14 citations

Formation of a Reactive Myosin-Phosphate Complex as a Key Reaction in Muscle Contraction

1965 • 14 citations

A nucleoside diphosphokinase from liver mitochondria which catalyzes an [32P] ADP-ATP exchange reaction

1962 • 13 citations

Determination of Oxygen-18 in Phosphate Ion

1960 • 12 citations

STUDIES IN OXIDATIVE PHOSPHORYLATION WITH RADIOACTIVE PHOSPHATE

1953 • 12 citations

Source of Oxygen in Adenosine Triphosphate Formed by Illumination or by Acid-Base Transition of Chloroplasts

1966 • 12 citations

A Reconsideration of the Isolation in Presence of EDTA and the Swelling-Contraction Characteristics of Rat Heart Sarcosomes. Metabolic Topography of the Sarcosomal Contractile Protein^*

1964 • 11 citations

Binding of p-nitrothiophenol to myosin a

1964 • 11 citations

ATP-ADP exchange catalyzed by coupling factor II

1964 • 11 citations

Sodium- potassium requiring adenosinetriphosphatase activity III. Purification and properties of the adenosinediphosphate-adenosinetriphosphate exchange enzyme

1966 • 10 citations

Kinetic evidence for a complex between the ATP-ADP exchange enzyme of oxidative phosphorylation and cytochrome C

1964 • 10 citations

Solvolysis of Phosphoric Acid Esters. Hydrolysis and Rearrangement Reactions of 1- and 2-Glycero Dihydrogen Phosphates and 1,2-Propanediol 1-Dihydrogen Phosphate

1966 • 10 citations

Adenosine Triphosphatase in Chloroplasts.

1959 • 10 citations

Phosphorylation of bound adenosine monophosphate in the electron transfer particle, driven by succinate

1965 • 9 citations

Light-Induced Dark [³²P]Adenosine Triphosphate Formation by Rhodospirillum rubrum Chromatophores. Adenosine Triphosphate-Inorganic Phosphate Exchange Activity^*

1966 • 9 citations

32P and 18O Exchange Reactions in Soluble Fractions Prepared from Rat Liver Mitochondria

1964 • 9 citations

Kinetic Relationships between Phosphate-Oxygen Exchange and Hydrolytic Cleavage of Adenosine Triphosphate Catalyzed by Myofibrils

1967 • 8 citations

A manganese stimulated, nucleotide dependent 18O-inorganic phosphate exchange reaction catalyzed by heavy meromyosin

1965 • 7 citations

The relation of the ATP-ADP exchange activity to photophosphorylation and to-3-phosphoglycerate kinase in spinach chloroplasts

1964 • 6 citations

A theory of respiratory chain oxidative phosphorylation.

1966 • 6 citations

The light-induced formation of rapidly phosphorylated compounds in chloroplasts

1965 • 6 citations

An intermediate of oxidative phosphorylation from Alcaligenes faecalis

1966 • 6 citations

Research with the isotopes of oxygen (O15, O17 and O18) during 1961–1963

1965 • 5 citations

Submicrodetermination of Oxygen-18-Benzophenone by Infrared Spectrometry.

1964 • 4 citations

A coenzyme A-dependent adenosinetriphosphate orthophosphate exchange reaction

1965 • 4 citations

Isolement d'un complexe enzyme d'échange ADP-ATP - cytochrome c réduit

1964 • 4 citations

A coenzyme A-dependent adenosinetriphosphate orthophosphate exchange reaction

1965 • 2 citations

Der Einflu� von Atractylosid auf den von Mitochondrien katalysierten18O-Austausch zwischen Phosphat und Wasser

1966 • 1 citations