Final Maturation of Dendritic Cells Is Associated with Impaired Responsiveness to IFN-γ and to Bacterial IL-12 Inducers: Decreased Ability of Mature Dendritic Cells to Produce IL-12 During the Interaction with Th Cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor Deficiency

1998 • 837 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Regulation of the immune response by prostaglandins

1983 • 717 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway.

1997 • 443 citations

The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation

1998 • 436 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

Prostaglandin E2 Induces the Final Maturation of IL-12-Deficient CD1a+CD83+ Dendritic Cells: The Levels of IL-12 Are Determined During the Final Dendritic Cell Maturation and Are Resistant to Further Modulation

1998 • 379 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co‐stimulatory molecules

1997 • 252 citations

The role of interleukin 12 in the immune response, disease and therapy

1994 • 221 citations

Structural characteristics of CD40 ligand that determine biological function

1994 • 166 citations

The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen.

1995 • 166 citations

Hyporesponsiveness of “naive” (CD45RA⁺) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

1990 • 118 citations

Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA

1985 • 117 citations

Functional Dichotomy between Langerhans Cells that Present Antigen to Naive and to Memory/Effector T Lymphocytes

1990 • 104 citations

Maturation and Migration of Cutaneous Dendritic Cells.

1995 • 93 citations

Dendritic Cell Accumulation in Draining Lymph Nodes during the Induction Phase of Contact Allergy in Mice

1989 • 92 citations

Interleukin-12 an integral cytokine in the immune response

1996 • 89 citations

Antigen-Bearing Langerhans Cells in Skin Draining Lymph Nodes: Phenotype and Kinetics of Migration

1994 • 73 citations

Matching antibody class with pathogen type and portal of entry: cognate mechanisms regulate local isotype expression patterns in lymph nodes draining the respiratory tract of mice inoculated with respiratory viruses, according to virus replication competence and site of inoculation.

1997 • 32 citations

Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages

1988 • 25 citations

Cited By (0)

No citing papers found in database