Inhibition of cGMP Breakdown Promotes the Induction of Cerebellar Long-Term Depression

Chelerythrine is a potent and specific inhibitor of protein kinase C

1990 • 1,208 citations

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells

1982 • 940 citations

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

1994 • 884 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

1994 • 730 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Synaptic excitation produces a long-lasting rebound potentiation of inhibitory synaptic signals in cerebellar Purkinje cells

1992 • 423 citations

Synaptic currents in cerebellar Purkinje cells.

1990 • 407 citations

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

1991 • 405 citations

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

1987 • 376 citations

Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells.

1992 • 358 citations

Participation of Postsynaptic PKC in Cerebellar Long-Term Depression in Culture

1991 • 340 citations

Subthreshold synaptic Ca2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons

1995 • 309 citations

Long-term depression of parallel fibre synapses following stimulation of climbing fibres

1985 • 280 citations

Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain.

1981 • 279 citations

Two types of calcium response limited to single spines in cerebellar Purkinje cells.

1995 • 275 citations

Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells

1994 • 274 citations

Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.

1990 • 254 citations

Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study

1988 • 234 citations

Mapping calcium transients in the dendrites of Purkinje cells from the guinea‐pig cerebellum in vitro.

1987 • 225 citations

Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients

1995 • 222 citations

An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture

1995 • 193 citations

Immunohistochemical localization of guanylate cyclase within neurons of rat brain.

1982 • 186 citations

Protein kinases, nitric oxide and long-term depression of synapses in the cerebellum

1990 • 182 citations

Long‐term Depression Requires Nitric Oxide and Guanosine 3′:5’Cyclic Monophosphate Production in Rat Cerebellar Purkinje Cells

1993 • 170 citations

Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses

1995 • 167 citations

Strong Activation of Parallel Fibers Produces Localized Calcium Transients and a Form of LTD That Spreads to Distant Synapses

1996 • 167 citations

Sources and targets of nitric oxide in rat cerebellum

1992 • 155 citations

Induction of cerebellar long-term depression requires activation of glutamate metabotropic receptors

1994 • 152 citations

Regulation of Neuronal Nitric Oxide and Cyclic GMP Formation by Ca²⁺

1992 • 151 citations

The Nitric Oxide ‐ Cyclic GMP Pathway and Synaptic Depression in Rat Hippocampal Slices

1994 • 141 citations

cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG

1994 • 140 citations

Induction of cerebellar long-term depression in culture requires postsynaptic action of Sodium Ions

1993 • 140 citations

Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells

1992 • 133 citations

Two Pathways of Cyclic GMP Production Through Glutamate Receptor‐Mediated Nitric Oxide Synthesis

1992 • 130 citations

Stimulus parameters for induction of long-term depression in in vitro rat Purkinje cells

1994 • 130 citations

Role of metabotropic glutamate (ACPD) receptors at the parallel fiber-Purkinje cell synapse

1992 • 129 citations

Receptors and Second Messengers Involved in Long‐term Depression in Rat Cerebellar Slices In Vitro: a Reappraisal

1995 • 128 citations

Long‐term Depression of Glutamate Currents in Cultured Cerebellar Purkinje Neurons Does Not Require Nitric Oxide Signalling

1992 • 125 citations

Nitric oxide-dependent efflux of cGMP in rat cerebellar cortex: an in vivo microdialysis study

1994 • 123 citations

Climbing Fibre Responses in Olivo‐cerebellar Slice Cultures. II. Dynamics of Cytosolic Calcium in Purkinje Cells

1991 • 103 citations

Differential localization of calmodulin-dependent enzymes in rat brain: evidence for selective expression of cyclic nucleotide phosphodiesterase in specific neurons.

1987 • 96 citations

Input-specific induction of cerebellar long-term depression does not require presynaptic alteration.

1994 • 78 citations

Novel synaptic potentials in cerebellar Purkenje cells: Probable mediation by metabotropic glutamate receptors

1993 • 77 citations

Evidence for transsynaptic regulation of calmodulin-dependent cyclic nucleotide phosphodiesterase in cerebellar Purkinje cells

1989 • 67 citations

Activation of the NO-cGMP signalling pathway depresses hippocampal synaptic transmission through an adenosine receptor-dependent mechanism

1994 • 49 citations

Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice

1995 • 34 citations

Receptor subtypes involved in, and time course of, the long-term desensitization of glutamate receptors in cerebellar Purkinje cells

1990 • 32 citations

Characterization and Regional Distribution of a Class of Synapses with Highly Concentrated cAMP Binding Sites in the Rat Brain

1991 • 13 citations