Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage‐colony stimulating factor‐deficient mice

Estimation of nuclear population from microtome sections

1946 • 4,378 citations

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 • 2,356 citations

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

1990 • 1,763 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1998 • 1,118 citations

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

1999 • 1,071 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

1993 • 1,009 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function

1999 • 830 citations

A Novel Geneiba1in the Major Histocompatibility Complex Class III Region Encoding an EF Hand Protein Expressed in a Monocytic Lineage

1996 • 813 citations

The role of microglia and macrophages in the pathophysiology of the CNS

1999 • 677 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat

1998 • 417 citations

Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia

2000 • 393 citations

Cytokine mRNA Profiles in Contused Spinal Cord and Axotomized Facial Nucleus Suggest a Beneficial Role for Inflammation and Gliosis

1998 • 347 citations

Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey

1986 • 339 citations

Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury

1998 • 330 citations

Colony-stimulating factors as promoters of ameboid microglia

1988 • 323 citations

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1991 • 304 citations

Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the Mouse

1976 • 302 citations

Impaired neuroglial activation in interleukin-6 deficient mice

1997 • 284 citations

Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways

1999 • 272 citations

Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons

1986 • 255 citations

Pseudorabies virus: a highly specific transneuronal cell body marker in the sympathetic nervous system

1990 • 234 citations

Microglial Response to Brain Injury: A Brief Synopsis

2000 • 229 citations

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

1998 • 226 citations

Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture

1991 • 213 citations

Interleukin‐6 and Transforming Growth Factor‐β1 mRNAs are Induced in Rat Facial Nucleus Following Motoneuron Axotomy

1993 • 205 citations

Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C

1990 • 198 citations

Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)

2000 • 190 citations

Delayed astrocyte reaction following facial nerve axotomy

1988 • 180 citations

Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in the Mouse

1994 • 170 citations

Excitotoxic brain damage in the rat induces interleukin-1? protein in microglia and astrocytes: Correlation with the progression of cell death

1999 • 166 citations

Impaired Axonal Regeneration in α7 Integrin-Deficient Mice

2000 • 165 citations

Macrophage phagocytosis of myelin in vitro determined by flow cytometry: phagocytosis is mediated by CR3 and induces production of tumor necrosis factor-α and nitric oxide

1996 • 164 citations

Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions

1971 • 156 citations

Electrophysiological properties of microglial cells in normal and pathologic rat brain slices

2000 • 155 citations

Transforming growth factor‐β1: A lesion‐associated cytokine of the nervous system

1995 • 150 citations

Microglia and the Immune Pathology of Alzheimer Disease

1999 • 143 citations

Single and multiple transgenic mice as models for Alzheimer's disease

2000 • 141 citations

Labelling of interneurones by retrograde transsynaptic transport of horseradish peroxidase from motoneurones in rats and cats

1984 • 139 citations

Regulation of thrombospondin in the regenerating mouse facial motor nucleus

1996 • 138 citations

Increase of macrophage colony‐stimulating factor and granulocyte‐macrophage colony‐stimulating factor receptors in the regenerating rat facial nucleus

1991 • 134 citations

Selective trans-synaptic migration of tetanus toxin after retrograde axonal transport in peripheral sympathetic nerves: A comparison with the nerve growth factor

1977 • 134 citations

Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration

2000 • 134 citations

T-cell activation: integration of signals from the antigen receptor and costimulatory molecules

1995 • 133 citations

Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons

1999 • 133 citations

Integrin family of cell adhesion molecules in the injured brain: Regulation and cellular localization in the normal and regenerating mouse facial motor nucleus

1999 • 132 citations

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF

1978 • 131 citations

Endogenous Ciliary Neurotrophic Factor Is a Lesion Factor for Axotomized Motoneurons in Adult Mice

1997 • 123 citations

Proliferation of ramified microglia on an astrocyte monolayer: Characterization of stimulatory and inhibitory cytokines

1997 • 118 citations

Differential expression of immediate early genes after transection of the facial nerve

1993 • 117 citations

Temporal Profile and Cellular Localization of Interleukin-6 Protein after Focal Cerebral Ischemia in Rats

1999 • 115 citations

Production of colony‐stimulating factor‐1 (CSF‐1) by mouse astroglia in vitro

1990 • 114 citations

Brain macrophages: neurotoxic or neurotrophic effector cells?

1994 • 113 citations

Regulation of MSCF receptors on microglia in the normal and injured mouse central nervous system: A quantitative immunofluorescence study using confocal laser microscopy

1998 • 113 citations

Expression of c-JUN, JUN B and JUN D proteins in rat nervous system following transection of vagus nerve and cervical sympathetic trunk

1991 • 110 citations

The hematopoietic cytokine, colony‐stimulating factor 1, is also a growth factor in the CNS: Congenital absence of CSF‐1 in mice results in abnormal microglial response and increased neuron vulnerability to injury

1995 • 97 citations

Synaptic Density of Axotomized Hypoglossal Motorneurons Following Pharmacological Blockade of the Microglial Cell Proliferation

1993 • 94 citations

Expression of macrophage colony‐stimulating factor gene in the mouse brain during development

1990 • 94 citations

Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat

2000 • 91 citations

Axonal Damage Induced by Invading T Cells in Organotypic Central Nervous System Tissue in vitro: Involvement of Microglial Cells

2000 • 89 citations

The significance of retrograde axonal transport for the accumulation of systemically administered nerve growth factor (NGF) in the rat superior cervical ganglion

1976 • 88 citations

Regulation of the cell adhesion molecule CD44 after nerve transection and direct trauma to the mouse brain

2000 • 87 citations

Increase of transferrin receptors and iron uptake in regenerating motor neurons

1989 • 82 citations

Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation.

1996 • 76 citations

Transforming growth factor β's 1, 2 and 3 inhibit proliferation of ramified microglia on an astrocyte monolayer

1998 • 69 citations

Molecular Genetics of Alzheimer Disease

1999 • 66 citations

Alzheimer Disease

2000 • 55 citations

Enzyme changes in the rat facial nucleus following a conditioning lesion

1984 • 55 citations

The acetylcholine receptor as a cellular receptor for rabies virus.

1983 • 53 citations

Changes of Coenzyme (TPN) Diaphorase and TPN-linked Dehydrogenase during Axonal Reaction of the Nerve Cell

1963 • 51 citations

Leukemia Inhibitory Factor and Nerve Growth Factor are Retrogradely Transported and Processed by Cultured Rat Sympathetic Neurons

1994 • 49 citations

Intercellular adhesion molecule-1 (ICAM-1) in the mouse facial motor nucleus after axonal injury and during regeneration.

1998 • 49 citations

Marked diversity in the action of growth factors on N-methyl-d-rmaspartate-induced neuronal degeneration

1996 • 44 citations

Regeneration of Hypoglossal Nerve Axons Following Blockade of the Axotomy‐induced Microglial Cell Reaction in the Rat

1993 • 42 citations

Transsynaptic spread of varicella zoster virus through the visual system: A mechanism of viral dissemination in the central nervous system

1989 • 41 citations

Identification of renal sympathetic preganglionic neurons in hamsters using transsynaptic transport of herpes simplex type 1 virus

1993 • 33 citations

Identification of CSF-1 as a brain macrophage migratory activity produced by astrocytes

1998 • 29 citations

Chapter 1 Peptides in motoneurons

1995 • 22 citations