Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1.

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

MAP kinase by any other name smells just as sweet

1992 • 341 citations

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.

1990 • 336 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.

1990 • 196 citations

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.

1990 • 175 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

1987 • 151 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.

1991 • 113 citations

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation

1990 • 107 citations

In vivo activation of a microtubule‐associated protein kinase during meiotic maturation of the Xenopus oocyte

1990 • 69 citations

IN VIVO ASSOCIATION OF [¹²⁵I]-INSULIN WITH A CYTOSOLIC INSULIN-DEGRADING ENZYME: DETECTION BY COVALENT CROSS-LINKING AND IMMUNOPRECIPITATION WITH A MONOCLONAL ANTIBODY

1987 • 60 citations

Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase

1991 • 32 citations