Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

2009 • 3,433 citations

Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database

2006 • 1,745 citations

Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval

2010 • 942 citations

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

2006 • 699 citations

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

2012 • 550 citations

Pathologic Complete Response Rates in Young Women With BRCA1-Positive Breast Cancers After Neoadjuvant Chemotherapy

2009 • 499 citations

Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

2012 • 479 citations

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

2012 • 475 citations

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

2012 • 425 citations

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

2008 • 409 citations

Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients

2008 • 325 citations

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

2010 • 245 citations

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor–resistant human lung adenocarcinoma

2011 • 159 citations

First-in-human trial of novel oral PARP inhibitor BMN 673 in patients with solid tumors.

2013 • 75 citations

Proteomic Profiling Identifies Pathways Dysregulated in Non-small Cell Lung Cancer and an Inverse Association of AMPK and Adhesion Pathways with Recurrence

2010 • 69 citations

Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical Parameters

2012 • 37 citations

Biological Prognostic and Predictive Factors in Lung Cancer

2009 • 29 citations

Novel Systemic Therapies for Small Cell Lung Cancer

2008 • 27 citations

Nonaneurysmal Subarachnoid Hemorrhage

2007 • 12 citations