Thrombomodulin.

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

1979 • 480 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta.

1985 • 413 citations

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

1987 • 399 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

1987 • 358 citations

Thrombomodulin is present in human plasma and urine.

1985 • 295 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1987 • 209 citations

Establishment of Enzyme Immunoassay of Human Thrombomodulin in Plasma and Urine Using Monoclonal Antibodies

1990 • 140 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.

1986 • 125 citations

A Plausible Mechanism for Prothrombin Activation by Factor Xa, Factor Va, Phospholipid, and Calcium Ions

1974 • 108 citations

The effect of bovine thrombomodulin on the specificity of bovine thrombin.

1986 • 106 citations

The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells.

1988 • 84 citations

Distribution of the thrombomodulin antigen in the rabbit vasculature.

1986 • 78 citations

Binding of thrombin to thrombomodulin accelerates inhibition of the enzyme by antithrombin III. Evidence for a heparin-independent mechanism

1987 • 70 citations

Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin.

1985 • 64 citations

Inhibition by human thrombomodulin of factor Xa-mediated cleavage of prothrombin.

1986 • 35 citations

Preparation of thrombomodulin from human placenta

1985 • 35 citations

Effect of rabbit thrombomodulin on thrombin inhibition by antithrombin in the presence of heparin

1989 • 25 citations

A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice

1988 • 14 citations

Thrombomodulin, an endothelial anticoagulant protein, is absent from the human brain

1986 • 14 citations

The Effects of Human Thrombomodulin on the Inactivation of Thrombin by Its Serum Inhibitors

1987 • 8 citations