Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

1987 • 4,980 citations

Prevalence of Vitamin D Insufficiency in an Adult Normal Population

1997 • 1,477 citations

Hypovitaminosis D in Medical Inpatients

1998 • 1,447 citations

INCREASED SKIN PIGMENT REDUCES THE CAPACITY OF SKIN TO SYNTHESISE VITAMIN D3

1982 • 1,154 citations

The Role of the Vitamin D Endocrine System in Health and Disease

1989 • 1,041 citations

Serum vitamin D concentrations among elderly people in Europe

1995 • 790 citations

Falls in the Elderly: A Prospective Study of Risk Factors and Risk Profiles

1996 • 774 citations

Environmental factors that influence the cutaneous production of vitamin D

1995 • 772 citations

The Vitamin D Endocrine System: Steroid Metabolism, Hormone Receptors, and Biological Response (Calcium Binding Proteins)*

1982 • 698 citations

Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women

1994 • 692 citations

Differences in vitamin D status between countries in young adults and the elderly

1992 • 627 citations

Skeletal disease in primary hyperparathyroidism

1989 • 616 citations

Geographic variation in breast cancer mortality in the United States: A hypothesis involving exposure to solar radiation

1990 • 579 citations

Occult Vitamin D Deficiency in Postmenopausal US Women With Acute Hip Fracture

1999 • 547 citations

Vitamin D and bone health in the elderly

1982 • 515 citations

Effect of Vitamin D Supplementation on Wintertime and Overall Bone Loss in Healthy Postmenopausal Women

1991 • 514 citations

Influence of the Vitamin D-binding Protein on the Serum Concentration of 1,25-Dihydroxyvitamin D3

1981 • 507 citations

Evidence for alteration of the vitamin D-endocrine system in blacks.

1985 • 457 citations

Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study

1996 • 440 citations

Role of Vitamin D in Skeletal Muscle Function*

1986 • 437 citations

Calcium nutrition and bone health in the elderly

1982 • 421 citations

Race and sex differences in hip fracture incidence.

1984 • 402 citations

An International Comparison of Serum 25-Hydroxyvitamin D Measurements

1999 • 388 citations

The Effect of Vitamin D Supplementation on Vitamin D Status and Parathyroid Function in Elderly Subjects*

1988 • 386 citations

The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis

1982 • 382 citations

Calcium Homeostasis in Immobilization: An Example of Resorptive Hypercalciuria

1982 • 379 citations

Deficient Production of 1,25-Dihydroxyvitamin D in Elderly Osteoporotic Patients

1981 • 373 citations

Annual injection of vitamin D and fractures of aged bones

1992 • 366 citations

Vitamin D and its Major Metabolites: Serum Levels after Graded Oral Dosing in Healthy Men

1998 • 364 citations

A non-(1–84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples

1998 • 360 citations

A new mechanism for induced vitamin D deficiency in calcium deprivation

1987 • 341 citations

The Histomorphometry of Bone in Primary Hyperparathyroidism: Preservation of Cancellous Bone Structure*

1990 • 329 citations

FREQUENCY OF OSTEOMALACIA AND OSTEOPOROSIS IN FRACTURES OF THE PROXIMAL FEMUR

1974 • 325 citations

Vitamin D. Basic Research and its Clinical Application

1979 • 318 citations

Muscle strength in the elderly: Its relation to vitamin d metabolites

1999 • 314 citations

Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D

1993 • 305 citations

Evidence for efficacy of drugs affecting bone metabolism in preventing hip fracture.

1992 • 293 citations

Vitamin D status and sex hormone binding globulin: Determinants of bone turnover and bone mineral density in elderly women

1995 • 292 citations

Hypervitaminosis D Associated with Drinking Milk

1992 • 285 citations

The Effects of Race and Body Habitus on Bone Mineral Density of the Radius, Hip, and Spine in Premenopausal Women*

1988 • 281 citations

Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample

1997 • 280 citations

Vitamin D Status and Related Parameters in a Healthy Population: The Effects of Age, Sex, and Season*

1990 • 278 citations

Quantum concept of bone remodeling and turnover: Implications for the pathogenesis of osteoporosis

1979 • 275 citations

Structure-function relationships in the vitamin D endocrine system

1995 • 268 citations

Vitamin D Conversion by Sarcoid Lymph Node Homogenate

1984 • 265 citations

Vitamin D Binding Protein (Gc-Globulin)*

1989 • 263 citations

Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D

1995 • 244 citations

Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency

1987 • 240 citations

Determinants of vitamin D status in patients with hip fracture and in elderly control subjects

1987 • 230 citations

Falls Relate to Vitamin D and Parathyroid Hormone in an Australian Nursing Home and Hostel

1999 • 219 citations

Nutritional status in a healthy elderly population: vitamin D

1982 • 217 citations

Ultraviolet Irradiation Corrects Vitamin D Deficiency and Suppresses Secondary Hyperparathyroidism in the Elderly

1998 • 216 citations

Sunlight and vitamin D status in normal Saudi subjects

1983 • 205 citations

Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: Evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action

1991 • 202 citations

Studies of Vitamin D Deficiency in Man

1975 • 199 citations

A Global Study of Vitamin D Status and Parathyroid Function in Postmenopausal Women with Osteoporosis: Baseline Data from the Multiple Outcomes of Raloxifene Evaluation Clinical Trial

2001 • 192 citations

Sex-specific and race-specific hip fracture rates.

1990 • 192 citations

Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial

1995 • 192 citations

The role of 1,25‐dihydroxyvitamin D in the mechanism of acquired vitamin D deficiency

1992 • 188 citations

Osteomalacia: Current Concepts

1978 • 187 citations

Measurement of 25-hydroxyvitamin D in serum and its relation to sunshine, age and vitamin D intake in the Danish population

1979 • 185 citations

Histomorphometric profile and vitamin d status in patients with femoral neck fracture

1982 • 185 citations

Newly identified actions of the vitamin D endocrine system

1992 • 179 citations

Increases in Immunoreactive Parathyroid Hormone with Age

1979 • 174 citations

Age-Related Changes in Parathyroid Hormone and Parathyroid Hormone Action in Normal Humans*

1984 • 174 citations

Vitamin D Status During Puberty in French Healthy Male Adolescents

1999 • 169 citations

Effects of Age and Estrogen Status on Serum Parathyroid Hormone Levels and Biochemical Markers of Bone Turnover in Women: A Population-Based Study

1997 • 167 citations

Radial and Vertebral Bone Density in White and Black Women: Evidence for Racial Differences in Premenopausal Bone Homeostasis*

1989 • 165 citations

Calcium and vitamin D supplements: effects on calcium metabolism in elderly people

1987 • 160 citations

Serum Levels of Free 1,25-Dihydroxyvitamin D in Vitamin D Toxicity

1995 • 153 citations

The Effect of Vitamin D Supplementation on the Bone Mineral Density of the Femoral Neck Is Associated with Vitamin D Receptor Genotype

1997 • 153 citations

Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis

1999 • 143 citations

OSTEOMALACIA–A COMMON DISEASE IN ELDERLY WOMEN

1967 • 141 citations

Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women

1993 • 137 citations

Calcium, Vitamin D, and Parathyroid Hormone Status in Young White and Black Women: Association with Racial Differences in Bone Mass*

1991 • 137 citations

Irreversible bone loss in osteomalacia. Comparison of radial photon absorptiometry with iliac bone histomorphometry during treatment.

1985 • 136 citations

Calciotropic Hormones and Bone Markers in the Elderly

1998 • 136 citations

Age-Related (Type II) Femoral Neck Osteoporosis in Men: Biochemical Evidence for Both Hypovitaminosis D– and Androgen Deficiency–Induced Bone Resorption

1997 • 131 citations

Age-related Changes in Parathyroid Hormone and 25 Hydroxycholecalciferol Levels

1983 • 131 citations

VITAMIN-D STATUS IN LONG-STAY GERIATRIC PATIENTS

1975 • 128 citations

High Prevalence of Hypovitaminosis D among Free-Living Postmenopausal Women Referred to an Osteoporosis Outpatient Clinic in Northern Italy for Initial Screening

1999 • 126 citations

Hypovitaminosis D and elevated serum alkaline phosphatase In elderly Irish people

1985 • 124 citations

Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate

1995 • 117 citations

Gains in Bone Mineral Density with Resolution of Vitamin D Intoxication

1997 • 116 citations

Determinants of Bone Loss from the Femoral Neck in Women of Different Ages

2000 • 115 citations

Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women

1993 • 115 citations

Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption

1996 • 114 citations

The incidence of hip fractures in independent and institutionalized elderly people

1994 • 114 citations

Clothing prevents ultraviolet-B radiation-dependent photosynthesis of vitamin D3

1992 • 112 citations

Seasonal Variation in Serum Concentrations of Parathyroid Hormone in Elderly People*

1983 • 111 citations

Vitamin D-dependent seasonal variation of PTH in growing male adolescents

1995 • 111 citations

Secondary hyperparathyroidism in elderly people: combined effect of renal insufficiency and vitamin D deficiency

1993 • 110 citations

25-HYDROXYLATION OF VITAMIN D IN PRIMARY BILIARY CIRRHOSIS

1977 • 110 citations

Vitamin D: A modulator of cell proliferation and differentiation

1990 • 109 citations

Markers of bone remodeling in the elderly subject: Effects of vitamin D insufficiency and its correction

1995 • 109 citations

Effect of Calcium or 25OH Vitamin D3 Dietary Supplementation on Bone Loss at the Hip in Men and Women over the Age of 60

2000 • 105 citations

Functional Improvement with Vitamin D Replenishment in a Cohort of Frail, Vitamin D‐Deficient Older People

1995 • 104 citations

Risk factors for hip fracture in a high incidence area: A case-control study from Oslo, Norway

1995 • 101 citations

Seasonal Variation of Biochemical Indexes of Bone Turnover: Results of a Population-Based Study

1998 • 100 citations

Vitamin D Requirements for Humans of All Ages: New Increased Requirements for Women and Men 50 years and Older

1998 • 100 citations

Demonstration of a difference in urinary calcium, not calcium absorption, in black and white adolescents

1993 • 100 citations

Calcium retention and hormone levels in black and white women on high- and low-calcium diets

1993 • 96 citations

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients

1999 • 93 citations

Fractured Neck of Femur in the Elderly: An Attempt to Identify Patients at Risk

1979 • 92 citations

Influence of Vitamin D Status on Insulin Secretion and Glucose Tolerance in the Rabbit*

1984 • 91 citations

Risk factors for secondary hyperparathyroidism in a nursing home population

1996 • 91 citations

Osteomalacia and osteoporosis in femoral neck fracture

1990 • 88 citations

DO VITAMIN D SUPPLEMENTS IMPROVE THE PHYSICAL CAPABILITIES OF ELDERLY HOSPITAL PATIENTS?

1985 • 85 citations

Primary hyperparathyroidism: effect of parathyroidectomy on regional bone mineral density in Danish patients: a three-year follow-up study

1999 • 84 citations

Vitamin D deficiency in homebound elderly persons

1995 • 82 citations

Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males

1987 • 77 citations

Resolution of Vitamin D Insufficiency in Osteopenic Patients Results in Rapid Recovery of Bone Mineral Density

1999 • 77 citations

An international comparison of vitamin D metabolite measurements.

1984 • 76 citations

Vitamin D Deficiency in Elderly Patients in a General Hospital

1989 • 76 citations

Cost-effectiveness of preventing hip fractures in the elderly population using vitamin D and calcium

1995 • 75 citations

The vitamin d receptor: A primitive steroid receptor related to thyroid hormone receptor

1988 • 74 citations

Importance of Albumin, 25(OH)-Vitamin D and IGFBP-3 as Risk Factors in Elderly Women and Men with Hip Fracture

1997 • 74 citations

Increased Catabolism of 25-Hydroxyvitamin D in Patients with Partial Gastrectomy and Elevated 1,25-Dihydroxyvitamin D Levels. Implications for Metabolic Bone Disease

1997 • 73 citations

Absence of metabolic bone disease in the proximal femur in patients with fracture of the femoral neck

1982 • 71 citations

Secondary Hyperparathyroidism in Patients from Western Australia with Hip Fracture: Relationship to Type of Hip Fracture, Renal Function, and Vitamin D Deficiency

1999 • 69 citations

Vitamin D Status of Elderly People in Spain

1989 • 67 citations

Vitamin D nutritional status and related biochemical indices in an autonomous elderly population

1988 • 65 citations

Vitamin D Deficiency in Welfare Institutions for the Aged

1980 • 64 citations

RESPONSE OF PLASMA-25-HYDROXYVITAMIN D TO ULTRAVIOLET IRRADIATION IN LONG-STAY GERIATRIC PATIENTS

1978 • 63 citations

Osteomalacia in Fractures of the Proximal Femur

1982 • 63 citations

PROPHYLACTIC VITAMIN D IN THE ELDERLY

1980 • 59 citations

The pathogenesis and treatment of hip fractures

1991 • 58 citations

Muscle weakness in intensive care patients: Initial manifestation of vitamin D deficiency

1994 • 58 citations

The effect of a short course of calcium and vitamin d on bone turnover in older women

1996 • 56 citations

Mild Vitamin D Deficiency and Secondary Hyperparathyroidism in Nursing Home Patients Receiving Adequate Dietary Vitamin D

1992 • 56 citations

OSTEOMALACIA IN ELDERLY PATIENTS WITH FRACTURE OF THE FEMORAL NECK

1973 • 55 citations

Low levels of serum calcidiol in an African population compared to a North European population

1999 • 54 citations

Calcidiol, Calcitriol and Parathyroid Hormone Serum Concentrations in Institutionalized and Ambulatory Elderly in Switzerland

1999 • 53 citations

Vitamin D status among patients with fractured neck of femur in Hong Kong

1990 • 52 citations

Vitamin D-Fortified Liquid Milk: Benefits for the Elderly Community-Based Population

1998 • 50 citations

Exogenous Calciferol (Vitamin D) and Vitamin D Endocrine Status among Elderly Nursing Home Residents in the New York City Area

1993 • 49 citations

Indices of calcium metabolism in women with hip fractures

1989 • 48 citations

Are Elderly Asians in Britain at a High Risk of Vitamin D Deficiency and Osteomalacia?

1995 • 47 citations

Impaired macrophage activation in vitamin D3 deficiency: differential in vitro effects of 1,25-dihydroxyvitamin D3 on mouse peritoneal macrophage functions.

1989 • 45 citations

Stimulation and suppression of intact parathyroid hormone (PTH1–84) in normal subjects and hyperparathyroid patients

1991 • 41 citations

Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential

1992 • 39 citations

A Preliminary Report of Vitamin D and Calcium Metabolism in Older African Americans

1993 • 38 citations

Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study

1988 • 37 citations

VITAMIN D PROPHYLAXIS IN THE ELDERLY: A SIMPLE EFFECTIVE METHOD SUITABLE FOR LARGE POPULATIONS

1985 • 36 citations

Vitamin D and the skin: photobiology, physiology and therapeutic efficacy for psoriasis

1990 • 36 citations

THE CURE OF INFANTILE RICKETS BY SUNLIGHT

1922 • 35 citations

The effect of trauma on serum concentrations of vitamin D metabolites in patients with hip fracture

1985 • 35 citations

Simultaneous determination of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1,25-dihydroxyvitamin D in plasma or serum.

1981 • 34 citations

Safety and efficacy of increasing wintertime vitamin D and calcium intake by milk fortification

1995 • 33 citations

Lack of Metabolic Bone Disease in Patients with Fracture of the Femoral Neck*

1981 • 31 citations

Influence of age and body mass on the effects of vitamin d on hip fracture risk

1995 • 29 citations

Low Prevalence of Osteomalacia in Elderly Patients with Hip Fracture

1991 • 28 citations

Insulin-Like Growth Factor-I Stimulates Renal 1,25-Dihydroxycholecalciferol Synthesis in Old Rats Fed a Low Calcium Diet

2000 • 28 citations

Vitamin D Metabolism and Osteomalacia in Patients with Fractures of the Proximal Femur

1982 • 28 citations

Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’?

1998 • 28 citations

25-Hydroxy-Vitamin D, Diet and Sunlight Exposure in Patients Admitted to a Geriatric Unit

1978 • 27 citations

Vitamin-D-Fortified Liquid Milk – A Highly Effective Method of Vitamin D Administration for House-Bound and Institutionalised Elderly

1992 • 27 citations

SUBTROCHANTERIC FRACTURES IN OSTEOMALACIA

1970 • 27 citations

A review of economic evaluation in osteoporosis

1999 • 27 citations

Dietary supplementation in elderly patients with fractured neck of the femur

1990 • 27 citations

Calcium absorption responses to calcitriol in black and white premenopausal women

1995 • 26 citations

Serum osteocalcin is increased in patients with osteomalacia: correlations with biochemical and histomorphometric findings

1992 • 25 citations

High-dose vitamin D therapy: indications, benefits and hazards.

1989 • 24 citations

Different responses of free and peptide-bound cross-links to vitamin D and calcium supplementation in elderly women with vitamin D insufficiency

1996 • 22 citations

Low vitamin D status is common among elderly Dunedin women.

1997 • 22 citations

Interlaboratory Variation of Vitamin D Metabolite Measurements

1982 • 21 citations

Insulin-like growth factor I increases renal 1,25(OH)2D3 biosynthesis during low-P diet in adult rats

1997 • 20 citations

Furosemide-Induced Reduction in Ionized Calcium in Hypoparathyroid Patients

1977 • 20 citations

Fracture of the Femoral Neck in the Elderly Assessment of the Role of Osteomalacia

1971 • 19 citations

Screening for osteomalacia in elderly patients with femoral neck fractures

1987 • 19 citations

Endogenous Hormones and the Risk of Hip and Vertebral Fractures Among Older Women

1999 • 19 citations

Nutritional situation of Beijing residents.

1992 • 16 citations

Can vitamin D deficiency produce an unusual pain syndrome?

1991 • 14 citations

Vitamin D status in urinary calcium stone formation

1985 • 13 citations

Osteomalacia as a Contributing Factor in Fracture of the Femoral Neck in the Elderly in Qatar

1978 • 13 citations

Vitamin D deficiency in the elderly

1991 • 11 citations

Does Calcium Intake Change Vitamin D Requirements?

1998 • 11 citations

Calcium, vitamin D and vitamin D metabolites

1996 • 11 citations

TIMING OF SCREENING FOR OSTEOMALACIA IN THE ACUTELY ILL ELDERLY

1986 • 11 citations

How About Vitamin D Receptor Polymorphisms?

1998 • 10 citations

Changing prevalence of osteomalacia in hip fractures in southeast Scotland over a 20-year period

1992 • 10 citations

The vitamin D content of fortified milk and infant formula

1993 • 10 citations

Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis

1985 • 9 citations

Diseases contributing to fragility of bone in patients with hip fractures.

1974 • 8 citations

Metabolic Disorders of Bone.

1975 • 7 citations

Bone density parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women

1993 • 5 citations

Single oral high dose vitamin D3 prophylaxis in the elderly

1986 • 3 citations

SEASONAL VARIATION OF HISTOLOGICAL OSTEOMALACIA IN FEMORAL-NECK FRACTURES

1974 • 2 citations

Heterogeneity of Fracture Syndromes in Postmenopausal Women

1986 • 2 citations