Isolation of the Thymidylate Synthetase Gene (TMP1) by Complementation in Saccharomyces cerevisiae

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid

1978 • 4,472 citations

Calcium-dependent bacteriophage DNA infection

1970 • 2,743 citations

Transduction of linked genetic characters of the host by bacteriophage P1

1955 • 2,703 citations

Transformation of yeast.

1978 • 2,267 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis

1973 • 1,616 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

The Biochemistry of Folic Acid and Related Pteridines.

1970 • 1,033 citations

Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event

1970 • 770 citations

Chapter 3 Isolation of Yeast DNA

1975 • 520 citations

Growth Requirements of Virus-Resistant Mutants of Escherichia Coli Strain “B”

1946 • 360 citations

Functional expression of cloned yeast DNA in Escherichia coli.

1977 • 284 citations

Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiae

1973 • 278 citations

Functional genetic expression of eukaryotic DNA in Escherichia coli.

1976 • 261 citations

Thymidine Kinase: Evidence for its Absence from Neurospora crassa and Some Other Micro-organisms, and the Relevance of This to the Specific Labelling of Deoxyribonucleic Acid

1968 • 203 citations

Production of a functional eukaryotic enzyme in Escherichia coli: cloning and expression of the yeast structural gene for imidazole-glycerolphosphate dehydratase (his3).

1977 • 147 citations

Expression in Escherichia coli K-12 of the structural gene for catabolic dehydroquinase of Neurospora crassa

1977 • 118 citations

Regulation of thymidylate synthetase in mouse leukemia cells (L1210).

1980 • 94 citations

Thymidine 5′-Monophosphate-Requiring Mutants of Saccharomyces cerevisiae Are Deficient in Thymidylate Synthetase

1977 • 86 citations

Chimeric plasmids for cloning of deoxyribonucleic acid sequences in Saccharomyces cerevisiae

1979 • 77 citations

Induction of mitotic recombination in yeast by starvation for thymine nucleotides.

1980 • 72 citations

Isolation of a condensed, intracellular form of the 2-micrometer DNA plasmid of Saccharomyces cerevisiae.

1979 • 72 citations

Genetic damage during thymidylate starvation in Saccharomyces cerevisiae

1978 • 70 citations

Isolation and characterization of yeast mutants auxotrophic for 2′-deoxythymidine 5′-monophosphate

1979 • 69 citations

Yeast cell-cycle mutantcdc21 is a temperature-sensitive thymidylate auxotroph

1976 • 64 citations

Regulation of thymidylate synthetase activity in cultured mammalian cells

1972 • 64 citations

High frequency recombination and the expression of genes cloned on chimeric yeast plasmids: Identification of a fragment of 2-?m circle essential for transformation

1980 • 46 citations

Mutation induction in yeast by deoxythymidine monophosphate: A model

1981 • 36 citations

Isolation and Characterization of Mutants of Saccharomyces cerevisiae Auxotrophic and Conditionally Auxotrophic for 5′ -dTMP

1974 • 36 citations

Nuclear morphology of yeast under thymidylate starvation

1981 • 8 citations