Oxygen Toxicity

The Biology of Oxygen Radicals

1978 • 3,361 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

1977 • 1,014 citations

Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

1977 • 1,004 citations

Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria.

1981 • 757 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

[33] Overview of methods used for detecting lipid peroxidation

1984 • 450 citations

DNA strand scission by enzymically generated oxygen radicals

1981 • 428 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Normobaric Oxygen Toxicity of the Lung

1980 • 375 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Pulmonary Oxygen Toxicity

1983 • 312 citations

Pulmonary Diseases and Disorders

1981 • 295 citations

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.

1979 • 293 citations

Leukocytes are required for increased lung microvascular permeability after microembolization in sheep.

1981 • 271 citations

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

1978 • 264 citations

Biochemical and metabolic changes in the lung with oxygen, ozone, and nitrogen dioxide toxicity.

1978 • 247 citations

Role of oxygen metabolites in immune complex injury of lung.

1981 • 224 citations

Pathologic changes in the lungs of oxygen-adapted rats: a morphometric analysis.

1978 • 213 citations

Biochemical and medical aspects of active oxygen

1977 • 199 citations

The Toxicity of Oxygen

1972 • 175 citations

Pulmonary Effects of Oxygen Breathing

1975 • 152 citations

Mechanisms of Oxidation with Oxygen

1965 • 144 citations

Protection against pulmonary oxygen toxicity in rats by the intratracheal administration of liposome-encapsulated superoxide dismutase or catalase.

1985 • 143 citations

Oxygen Toxicity in Man

1970 • 141 citations

Changes in lung volume, diffusing capacity, and blood gases in men breathing oxygen.

1966 • 134 citations

Generation of a chemotactic lipid from arachidonic acid by exposure to a superoxide-generating system

1980 • 134 citations

Adverse Effect of Oxygen on Tracheal Mucus Flow

1968 • 116 citations

Oxygen Pneumonitis in Man

1972 • 93 citations

Oxygen Therapy

1980 • 85 citations

Superoxide dismutase with heparin prevents increased lung vascular permeability during air emboli in sheep

1983 • 82 citations

Nylon fiber leukapheresis: associated complement component changes and cranulocytopenia

1978 • 80 citations

New biological activity following intravascular activation of the complement cascade

1974 • 79 citations

Superoxide radical: A likely link between reperfusion injury and inflammation

1986 • 77 citations

Protection from O2 toxicity by preexposure to hypoxia: lung antioxidant enzyme role

1982 • 75 citations

Dihydroorotate Dehydrogenase

1967 • 68 citations

Pulmonary injury in rats following continuous exposure to 60% O2 for 7 days

1981 • 67 citations

Oxidation Effects in a Freeze‐Dried Gelatin‐Methyl Linoleate System

1969 • 67 citations

One Hundred Percent Oxygen Lung Injury in Adult Baboons

1987 • 59 citations

Altered sensitivity to oxygen toxicity.

1977 • 52 citations

The experimental pathology of oxidant and air pollutant inhalation.

1980 • 47 citations

Prolonged survival after paraquat

1981 • 44 citations

Ozone-induced tolerance to hyperoxia in rats.

1984 • 43 citations

Species variation in lung antioxidant enzyme activities

1987 • 38 citations

Septicemia and Lung Injury

1983 • 38 citations

Impairment of phagocytosis by moderate hyperoxia (40 to 60 per cent oxygen) in lung macrophages.

1980 • 35 citations

Decreased Bactericidal Function and Impaired Respiratory Burst in Lung Macrophages after Sustained in vitro Hyperoxia

1983 • 33 citations

Biochemical and cellular aspects of pulmonary oxygen toxicity

1985 • 30 citations

Oxygen Toxicity and Protective Systems

1985 • 28 citations

Enhanced pulmonary toxicity in copper-deficient rats exposed to hyperoxia*1

1984 • 28 citations

Oxygen toxicity: Protection of the lung by bacterial lipopolysaccharide (endotoxin)

1979 • 28 citations

Effect of high oxygen tension on mucociliary function.

1972 • 25 citations

Non-selenium-dependent glutathione peroxidase activity in rat lung: Association with lung glutathione S-transferase activity and the effects of hyperoxia

1983 • 25 citations

Oxygen radicals in complement and neutrophil-mediated acute lung injury

1985 • 22 citations

Effect of O2 exposure on metabolism of the rabbit alveolar macrophage.

1974 • 21 citations

Biochemical and anatomical adaptation of the lung to oxygen-induced injury.

1978 • 19 citations

The effect of hyperoxia on migration of alveolar macrophages in vitro.

1979 • 19 citations

Endotoxin protects selenium-deficient rats from hyperoxia.

1984 • 18 citations

Effects of oxygen toxicity on regional ventilation and perfusion in the primate lung.

1981 • 14 citations