Domain motions in proteins

Structure of human pancreatic lipase

1990 • 1,203 citations

A serine protease triad forms the catalytic centre of a triacylglycerol lipase

1990 • 1,198 citations

A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

1991 • 1,112 citations

Crystallographic refinement and atomic models of two different forms of citrate synthase at 2·7 and 1·7 Å resolution

1982 • 495 citations

The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis.

1991 • 437 citations

The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes.

1990 • 404 citations

Flavins and Flavoproteins 1990

1991 • 370 citations

Apolactoferrin structure demonstrates ligand-induced conformational change in transferrins

1990 • 359 citations

Glucose-induced conformational change in yeast hexokinase.

1978 • 305 citations

Anatomy of a Conformational Change: Hinged "Lid" Motion of the Triosephosphate Isomerase Loop

1990 • 282 citations

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

1990 • 247 citations

The calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution Implications for membrane binding and calcium channel activity

1990 • 240 citations

Structure at 2.5-.ANG. resolution of chemically synthesized Human Immunodeficiency Virus Type 1 protease complexed with a hydroxyethylene-based inhibitor

1991 • 231 citations

A mutant T4 lysozyme displays five different crystal conformations

1990 • 231 citations

Periplasmic binding protein structure and function

1989 • 229 citations

Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607

1991 • 201 citations

Induced-fit movements in adenylate kinases

1990 • 198 citations

Convergent evolution of similar function in two structurally divergent enzymes

1991 • 191 citations

Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 Å resolution

1991 • 187 citations

Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-.ANG. resolution

1990 • 121 citations

The refined structure of the complex between adenylate kinase from beef heart mitochondrial matrix and its substrate AMP at 1.85 Å resolution

1991 • 113 citations

Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium.

1990 • 112 citations

Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.

1990 • 108 citations

Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-.ANG. resolution and neutral pH

1990 • 95 citations

Structure of the l-leucine-binding protein refined at 2.4 Å resolution and comparison with the Leu/Ile/Val-binding protein structure

1989 • 94 citations

Normal mode analysis of human lysozyme: Study of the relative motion of the two domains and characterization of the harmonic motion

1990 • 90 citations

The mutation β99 Asp‐Tyr stabilizes Y—A new, composite quaternary state of human hemoglobin

1991 • 83 citations

High-resolution X-ray studies on rabbit serum transferrin: preliminary structure analysis of the N-terminal half-molecule at 2.3 Å resolution

1990 • 76 citations

Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5′-)pentaphosphate

1988 • 70 citations

The effect of iron binding on the conformation of transferrin. A small angle x-ray scattering study

1985 • 64 citations

The open/closed conformational equilibrium of aspartate aminotransferase

1991 • 55 citations

The three‐dimensional structure of glutathione reductase from Escherichia coli at 3.0 Å resolution

1991 • 32 citations

A proton‐NMR study of a site‐directed mutation (His388 → Glu) in the interdomain region of yeast phosphoglycerate kinase

1991 • 19 citations