Recombinant human erythropoietin and the anemia of cancer [editorial]

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein

1988 • 1,042 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Decreased Erythropoietin Response in Patients with the Anemia of Cancer

1990 • 680 citations

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells.

1990 • 574 citations

Erythropoietin Treatment of Anemia Associated with Multiple Myeloma

1990 • 459 citations

Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.

1988 • 448 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Anemia of Chronic Disorders

1984 • 419 citations

Prudent Strategies for Elective Red Blood Cell Transfusion

1992 • 363 citations

Recombinant Human Erythropoietin for Patients with AIDS Treated with Zidovudine

1990 • 347 citations

Granulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1988 • 296 citations

Multicenter study of recombinant human erythropoietin in correction of anemia in rheumatoid arthritis

1990 • 237 citations

Blunted erythropoietin response to anaemia in rheumatoid arthritis

1987 • 221 citations

Monokines inhibiting erythropoietin production in human hepatoma cultures and in isolated perfused rat kidneys

1992 • 209 citations

Recombinant human erythropoietin treatment in cisplatin-associated anemia: a randomized, double-blind trial with placebo.

1994 • 205 citations

Plasma erythropoietin in men and mice during acclimatization to different altitudes

1972 • 171 citations

Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration.

1990 • 162 citations

Development of radioimmunoassays for human erythropoietin using recombinant erythropoietin as tracer and immunogen

1987 • 158 citations

Tumor necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells.

1987 • 155 citations

Increased Erythropoiesis Induced by Androgenic-Hormone Therapy

1957 • 150 citations

Relation of serum erythropoietin levels to renal excretory function: Evidence for lowered set point for erythropoietin production in chronic renal failure

1988 • 126 citations

Treatment of chemotherapy-induced anemia with recombinant human erythropoietin in cancer patients.

1991 • 119 citations

Prostate cancer recurrence in radical surgery patients receiving autologous or homologous blood

1992 • 108 citations

Erythropoietin treatment for chronic anemia of selected hematological malignancies and solid tumors

1993 • 98 citations

Effects of Oxygen Inhalation on Endogenous Erythropoietin Kinetics, Erythropoiesis, and Properties of Blood Cells in Sickle-Cell Anemia

1984 • 96 citations

Recombinant human erythropoietin (r-HuEPO) for the treatment of the anemia of cancer

1991 • 91 citations

Correlation between neopterin, interferon‐gamma and haemoglobin in patients with haematological disorders

1990 • 77 citations

Erythropoiesis and Mean Red‐Cell Lifespan in Normal Subjects and in Patients with the Anaemia of Active Rheumatoid Arthritis

1978 • 71 citations

Decline of erythropoietin formation at continuous hypoxia is not due to feedback inhibition

1990 • 70 citations

Mechanisms of abnormal erythropoiesis in malignancy

1983 • 70 citations

Treatment of the anemia of chronic renal failure with subcutaneous recombinant human erythropoietin

1990 • 61 citations

Studies on the role of recombinant human erythropoietin in the growth regulation of human nonhematopoietic tumor cells in vitro

1991 • 60 citations

Erythropoietin life span in rats with hypoplastic and hyperplastic bone marrows

1991 • 59 citations

Evaluation of erythropoiesis after bone marrow transplantation: quantitative reticulocyte counting

1992 • 58 citations

Evidence for the De Novo Synthesis of Erythropoietin in Hypoxic Rats

1972 • 56 citations

Serum immunoreactive erythropoietin in HIV-infected patients

1989 • 55 citations

Recombinant human erythropoietin and the anemia of multiple myeloma

1993 • 52 citations

EFFECT OF ERYTHROPOIETIN ON PROLIFERATION OF ERYTHROPOIETIN-RESPONSIVE CELLS

1972 • 49 citations

Effect of recombinant human erythropoietin on anticancer drug‐induced anaemia

1990 • 49 citations

Effect of inflammatory cytokines on hypoxia-induced erythropoietin production

1992 • 48 citations

Erythropoietin Response to Anemia as a Function of Age

1991 • 47 citations

Experience of pain after subcutaneous administration of different preparations of recombinant human erythropoietin: a randomized, double-blind crossover study.

1991 • 47 citations

Effect of cis‐diamminedichloroplatinum on erythropoietin production and hematopoietic progenitor cells

1985 • 45 citations

ERYTHROPOIETIN‐INDEPENDENT REGENERATION OF ERYTHROID PROGENITOR CELLS FOLLOWING MULTIPLE INJECTIONS OF HYDROXYUREA

1980 • 44 citations

Expression of the erythropoietin receptor on a human myeloma cell line

1990 • 42 citations

The Anaemia of Chronic Disorders: Studies of Iron Reutilization in the Anaemia of Experimental Malignancy and Chronic Inflammation

1977 • 41 citations

The Mechanism by Which Plethora Suppresses Erythropoiesis

1969 • 39 citations

The Use of Recombinant Human Erythropoietin to Prevent Carboplatin-Induced Anemia

1993 • 39 citations

Anemia in malignant neoplastic disease

1963 • 39 citations

Recombinant human erythropoietin activates a broad spectrum of progenitor cells

1990 • 36 citations

Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization

1988 • 36 citations

Recombinant human erythropoietin for the treatment of chronic anemia in multiple myeloma and squamous cell carcinoma

1993 • 36 citations

Effect of repeated whole blood donations on serum immunoreactive erythropoietin levels in autologous donors

1988 • 35 citations

Control of Erythropoiesis in Rats With Adjuvant-induced Chronic Inflammation

1973 • 33 citations

Recombinant Human Erythropoietin in Patients with Ovarian Carcinoma and Anaemia Secondary to Cisplatin and Carboplatin Chemotherapy: Preliminary Results

1992 • 32 citations

The Value of the Peripheral Blood Smear in Anemic Inpatients

1983 • 28 citations

Intact transferrin receptors in human plasma and their relation to erythropoiesis

1990 • 27 citations

Recombinant Human Erythropoietin Treatment: Investigational New Drug Protocol for the Anemia of the Acquired Immunodeficiency Syndrome

1993 • 26 citations

Correlation between Bioassay and Radioimmunoassay for Erythropoietin in Human Serum and Urine Concentrates

1985 • 24 citations

Evaluation of erythroid marrow response to recombinant human erythropoietin in patients with cancer anaemia.

1992 • 23 citations

Clinical application of recombinant human erythropoietin for treatments in patients with head and neck cancer

1993 • 23 citations

Analysis of anemia in medical inpatients

1974 • 22 citations

The anemia of chronic disorders: studies of marrow regulation and iron metabolism

1975 • 21 citations

Erythropoietin and the anemia of mice bearing extramedullary tumor.

1979 • 21 citations

Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration

1989 • 21 citations

Stem cell defects after cytoreductive therapy in man.

1985 • 18 citations

Regulation of the plasma erythropoietin level in hypoxic rats.

1984 • 17 citations

Suppressive effect of human interferons on erythroid colony growth in disorders of erythropoiesis.

1980 • 16 citations

Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice

1989 • 16 citations

Comparative toxicity of mitoxantrone and doxorubicin on hematopoietic stem cells.

1985 • 15 citations

Physiologic regulation and tissue localization of renal erythropoietin messenger RNA

1987 • 15 citations

Anemia. Textbook vs practice

1979 • 13 citations

The anemia of chronic disease: Spectrum of associated diseases in a series of unselected hospitalized patients

1989 • 12 citations

Erythropoietin is both a mitogen and a survival factor

1991 • 12 citations

Serum erythropoietin levels in patients receiving intensive chemotherapy and radiotherapy

1990 • 11 citations

Effects of recombinant erythropoietin on the concentration and cycling status of human marrow hematopoietic progenitor cells in vivo

1988 • 9 citations

Blood Transfusions and Prognosis in Colorectal Cancer

1993 • 9 citations

Sickle cell anemia patients have low erythropoietin levels for their degree of anemia

1986 • 9 citations

Erythropoietin increases hemoglobin in cancer patients during radiation therapy

1992 • 8 citations

Recombinant human erythropoietin in a patient with multiple myeloma and end-stage renal disease.

1992 • 8 citations

Serum immunoreactive erythropoietin in children with cyanotic and acyanotic congenital heart disease

1987 • 5 citations

Growth of clonogenic myeloblastic leukemic cells in the presence of human recombinant erythropoietin in addition to various human recombinant hematopoietic growth factors

1988 • 4 citations

Serum erythropoietin levels in gynecologic cancer patients during cisplatin combination chemotherapy

1993 • 1 citations