Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

2014 • 26,824 citations

Sorafenib in Advanced Hepatocellular Carcinoma

2008 • 11,718 citations

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

2008 • 5,494 citations

Hepatocellular carcinoma

2018 • 4,383 citations

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

2018 • 4,279 citations

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

2017 • 3,754 citations

Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

2010 • 3,699 citations

Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial

2002 • 3,356 citations

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

2016 • 3,172 citations

Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level

2006 • 3,012 citations

Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

2003 • 2,945 citations

Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

2002 • 2,536 citations

Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial

2018 • 2,153 citations

Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade

2014 • 2,142 citations

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

2017 • 1,922 citations

Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children

1997 • 1,836 citations

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis

2008 • 1,816 citations

Liver biopsy

2008 • 1,706 citations

Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study

2009 • 1,475 citations

Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma

2002 • 1,445 citations

Randomized controlled trial of screening for hepatocellular carcinoma

2004 • 1,388 citations

A Prospective Randomized Trial Comparing Percutaneous Local Ablative Therapy and Partial Hepatectomy for Small Hepatocellular Carcinoma

2006 • 1,362 citations

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

2015 • 1,131 citations

Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma

2007 • 992 citations

Strategies for Safer Liver Surgery and Partial Liver Transplantation

2007 • 966 citations

Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report

2011 • 949 citations

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

2015 • 948 citations

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C

2013 • 896 citations

Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia # †

2008 • 796 citations

Meta‐analysis: surveillance with ultrasound for early‐stage hepatocellular carcinoma in patients with cirrhosis

2009 • 761 citations

A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan Criteria

2010 • 760 citations

Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

2017 • 690 citations

A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma

2012 • 684 citations

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

2017 • 618 citations

Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial

2016 • 616 citations

Radioembolization Results in Longer Time-to-Progression and Reduced Toxicity Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

2010 • 608 citations

A Randomized Phase III Study of Doxorubicin Versus Cisplatin/Interferon α-2b/Doxorubicin/Fluorouracil (PIAF) Combination Chemotherapy for Unresectable Hepatocellular Carcinoma

2005 • 588 citations

Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients

2001 • 569 citations

Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

2016 • 567 citations

SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma

2018 • 545 citations

Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma

2011 • 544 citations

Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma

2014 • 532 citations

Liver Transplantation for Hepatocellular Carcinoma: Validation of the UCSF‐Expanded Criteria Based on Preoperative Imaging

2007 • 529 citations

Hepatocellular carcinomas in patients with metabolic syndrome often develop without significant liver fibrosis: A pathological analysis

2008 • 529 citations

Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: Analysis of two phase III studies

2017 • 515 citations

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

2008 • 502 citations

Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma

2004 • 488 citations

Hepatocellular carcinoma risk following direct-acting antiviral HCV therapy: A systematic review, meta-analyses, and meta-regression

2017 • 460 citations

Hepatocellular Carcinoma: Diagnostic Performance of Multidetector CT and MR Imaging—A Systematic Review and Meta-Analysis

2015 • 455 citations

Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design

2012 • 451 citations

Hepatocellular Carcinoma

2011 • 447 citations

LI‐RADS (Liver Imaging Reporting and Data System): Summary, discussion, and consensus of the LI‐RADS Management Working Group and future directions

2014 • 447 citations

Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia

2013 • 445 citations

Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma

2010 • 435 citations

Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial

2017 • 427 citations

Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030

2016 • 406 citations

Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012

2016 • 389 citations

Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma

2015 • 375 citations

Prospective Randomized Comparison of Chemoembolization with Doxorubicin-Eluting Beads and Bland Embolization with BeadBlock for Hepatocellular Carcinoma

2009 • 369 citations

Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: A randomized trial comparing 3- and 6-month periodicities

2010 • 368 citations

Cost-effectiveness of screening for detection of small hepatocellular carcinoma in western patients with Child-Pugh class A cirrhosis

1996 • 359 citations

Comparison of resection and ablation for hepatocellular carcinoma: A cohort study based on a Japanese nationwide survey

2012 • 359 citations

Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma

2013 • 358 citations

Randomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone

2016 • 333 citations

Growth and spread of hepatocellular carcinoma: A review of 240 consecutive autopsy cases

1990 • 331 citations

Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: Incidence and survival in hepatitis C patients with advanced fibrosis

2010 • 331 citations

Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: A systematic review and meta‐analysis

2014 • 329 citations

Clinical features and outcomes of cirrhosis due to non‐alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C

2008 • 319 citations

A simple prognostic scoring system for patients receiving transarterial embolisation for hepatocellular cancer

2013 • 319 citations

Tivantinib for second-line treatment of MET-high, advanced hepatocellular carcinoma (METIV-HCC): a final analysis of a phase 3, randomised, placebo-controlled study

2018 • 317 citations

The ART of decision making: Retreatment with transarterial chemoembolization in patients with hepatocellular carcinoma

2013 • 314 citations

Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: A randomized phase III trial

2014 • 309 citations

EASL and mRECIST responses are independent prognostic factors for survival in hepatocellular cancer patients treated with transarterial embolization

2011 • 307 citations

Quality Improvement Guidelines for Radiofrequency Ablation of Liver Tumours

2009 • 300 citations

Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: A meta-analysis

2010 • 287 citations

Phase III Randomized Controlled Trial Comparing the Survival of Patients With Unresectable Hepatocellular Carcinoma Treated With Nolatrexed or Doxorubicin

2007 • 277 citations

Evidence Supporting LI-RADS Major Features for CT- and MR Imaging–based Diagnosis of Hepatocellular Carcinoma: A Systematic Review

2017 • 268 citations

The role of diabetes in hepatocellular carcinoma: a case-control study among United States veterans

2001 • 265 citations

Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease

2017 • 249 citations

Which Response Criteria Best Help Predict Survival of Patients with Hepatocellular Carcinoma Following Chemoembolization? A Validation Study of Old and New Models

2011 • 244 citations

Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules

2017 • 230 citations

Is Portal Hypertension a Contraindication to Hepatic Resection?

2009 • 227 citations

Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis

2011 • 201 citations

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

2017 • 197 citations

Comparative 13-year meta-analysis of the sensitivity and positive predictive value of ultrasound, CT, and MRI for detecting hepatocellular carcinoma

2015 • 191 citations

Chemoembolization With Doxorubicin-Eluting Beads for Unresectable Hepatocellular Carcinoma: Five-Year Survival Analysis

2012 • 190 citations

Liver Transplantation for Hepatocellular Carcinoma: Beyond the Milan Criteria

2008 • 184 citations

Yttrium 90 radioembolization for the treatment of hepatocellular carcinoma: Biological lessons, current challenges, and clinical perspectives

2013 • 171 citations

Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Localized Hepatocellular Carcinoma in Nonsurgically Managed Patients: Analysis of the National Cancer Database

2018 • 170 citations

Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma

2015 • 166 citations

Optimization of imaging diagnosis of 1–2cm hepatocellular carcinoma: An analysis of diagnostic performance and resource utilization

2010 • 164 citations

Orantinib versus placebo combined with transcatheter arterial chemoembolisation in patients with unresectable hepatocellular carcinoma (ORIENTAL): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study

2017 • 161 citations

Combined α fetoprotein testing and ultrasonography as a screening test for primary liver cancer

1999 • 160 citations

Erratum: Advances in targeted therapies for hepatocellular carcinoma in the genomic era

2015 • 152 citations

Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir

2014 • 151 citations

Risk of Recurrence in a Long-term Follow-up After Surgery in 417 Patients With Hepatitis B- or Hepatitis C-Related Hepatocellular Carcinoma

2006 • 150 citations

Evolution of Hypointense Hepatocellular Nodules Observed Only in the Hepatobiliary Phase of Gadoxetate Disodium–Enhanced MRI

2011 • 150 citations

CEUS in Hepatocellular Carcinoma and Intrahepatic Cholangiocellular Carcinoma in 320 Patients – Early or Late Washout Matters: A Subanalysis of the DEGUM Multicenter Trial

2015 • 144 citations

A randomised phase II/III trial of 3-weekly cisplatin-based sequential transarterial chemoembolisation vs embolisation alone for hepatocellular carcinoma

2013 • 133 citations

Prognostic Relevance of Objective Response According to EASL Criteria and mRECIST Criteria in Hepatocellular Carcinoma Patients Treated with Loco-Regional Therapies: A Literature-Based Meta-Analysis

2015 • 130 citations

Critical evaluation of the American Joint Commission on Cancer (AJCC) 8th edition staging system for patients with Hepatocellular Carcinoma (HCC): A Surveillance, Epidemiology, End Results (SEER) analysis

2017 • 130 citations

A Comprehensive Meta-regression Analysis on Outcome of Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma

2012 • 122 citations

The ART-strategy: Sequential assessment of the ART score predicts outcome of patients with hepatocellular carcinoma re-treated with TACE

2013 • 117 citations

Computed Tomography–Guided High-Dose-Rate Brachytherapy in Hepatocellular Carcinoma: Safety, Efficacy, and Effect on Survival

2010 • 117 citations

mRECIST and EASL responses at early time point by contrast-enhanced dynamic MRI predict survival in patients with unresectable hepatocellular carcinoma (HCC) treated by doxorubicin drug-eluting beads transarterial chemoembolization (DEB TACE)

2012 • 116 citations

Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma

2011 • 110 citations

Contrast-enhanced magnetic resonance imaging of 102 nodules in cirrhosis: correlation with histological findings on explanted livers

2012 • 107 citations

Comparison of radiation therapy modalities for hepatocellular carcinoma with portal vein thrombosis: A meta-analysis and systematic review

2017 • 101 citations

Cabozantinib (C) versus placebo (P) in patients (pts) with advanced hepatocellular carcinoma (HCC) who have received prior sorafenib: Results from the randomized phase III CELESTIAL trial.

2018 • 96 citations

REACH-2: A randomized, double-blind, placebo-controlled phase 3 study of ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma (HCC) and elevated baseline alpha-fetoprotein (AFP) following first-line sorafenib.

2018 • 92 citations

Meta-Analysis of Trials Comparing Minimally-Invasive and Open Liver Resections for Hepatocellular Carcinoma

2011 • 88 citations

Which is the best MRI marker of malignancy for atypical cirrhotic nodules: Hypointensity in hepatobiliary phase alone or combined with other features? Classification after Gd‐EOB‐DTPA administration

2012 • 85 citations

Transarterial Chemoembolization and Radioembolization

2014 • 82 citations

Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C

2009 • 80 citations

Transarterial chemo-embolisation of hepatocellular carcinoma: impact of liver function and vascular invasion

2017 • 67 citations

<scp>mRECIST</scp> to predict survival in advanced hepatocellular carcinoma: Analysis of two randomised phase <scp>II</scp> trials comparing nintedanib vs sorafenib

2017 • 63 citations

Preoperative prediction of microvascular invasion of hepatocellular carcinoma using 18F-FDG PET/CT: a multicenter retrospective cohort study

2017 • 63 citations

Consensus on Stereotactic Body Radiation Therapy for Small-Sized Hepatocellular Carcinoma at the 7th Asia-Pacific Primary Liver Cancer Expert Meeting

2017 • 55 citations

Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid (Gd-EOB-DTPA)-Enhanced Magnetic Resonance Imaging and Multidetector-Row Computed Tomography for the Diagnosis of Hepatocellular Carcinoma

2015 • 48 citations

Meta‐analysis of laparoscopic versus open liver resection for hepatocellular carcinoma

2018 • 47 citations

Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications

2015 • 45 citations

Radioembolization for hepatocellular carcinoma: Statistical confirmation of improved survival in responders by landmark analyses

2017 • 45 citations

Steatohepatitic variant of hepatocellular carcinoma in the absence of metabolic syndrome or background steatosis: a clinical, pathological, and genetic study

2015 • 44 citations

CT-guided high-dose-rate brachytherapy of unresectable hepatocellular carcinoma

2014 • 39 citations

The impact of combining Selective Internal Radiation Therapy (SIRT) with Sorafenib on overall survival in patients with advanced hepatocellular carcinoma: The Soramic trial palliative cohort

2018 • 38 citations

Preoperative tumour biopsy does not affect the oncologic course of patients with transplantable HCC

2014 • 38 citations

Imaging of Hepatocellular Carcinoma Response After⁹⁰Y Radioembolization

2017 • 32 citations

CT-guided Interstitial Brachytherapy of Hepatocellular Carcinoma before Liver Transplantation: an Equivalent Alternative to Transarterial Chemoembolization?

2015 • 29 citations

Excellent response to Anti-PD-1 therapy in a patient with hepatocellular carcinoma: case report and review of literature.

2017 • 26 citations

Non-Hypervascular Hypointense Nodules ≥1 cm on the Hepatobiliary Phase of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Cirrhotic Livers

2014 • 25 citations

Radiofrequency Ablation Is Superior to Ethanol Injection in Early-Stage Hepatocellular Carcinoma Irrespective of Tumor Size

2013 • 25 citations

Functional imaging of hepatocellular carcinoma using diffusion-weighted MRI and 18F-FDG PET/CT in patients on waiting-list for liver transplantation

2016 • 21 citations

Experience from a real-life cohort: outcome of 606 patients with hepatocellular carcinoma following transarterial chemoembolization

2016 • 15 citations

Is bone scintigraphy indicated in surgical work-up for hepatocellular carcinoma patients?

2012 • 15 citations

CT-Guided High-Dose-Rate Brachytherapy of Liver Tumours Does Not Impair Hepatic Function and Shows High Overall Safety and Favourable Survival Rates

2014 • 13 citations