Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Promotion of Trophoblast Stem Cell Proliferation by FGF4

1998 • 1,340 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

Regulation of Human Placental Development by Oxygen Tension

1997 • 905 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

2000 • 893 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits

1993 • 744 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia.

1996 • 560 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

1993 • 534 citations

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

1998 • 524 citations

Oxygen(es) and the hypoxia-inducible factor-1.

1997 • 518 citations

Generating green fluorescent mice by germline transmission of green fluorescent ES cells

1998 • 479 citations

The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling

2000 • 451 citations

Genomic imprinting of Mash2, a mouse gene required for trophoblast development

1995 • 366 citations

ARNT-Deficient Mice and Placental Differentiation

1997 • 331 citations

Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse

1998 • 325 citations

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1995 • 321 citations

Control of Drosophila body pattern by the hunchback morphogen gradient

1992 • 294 citations

Fibronectins Are Essential for Heart and Blood Vessel Morphogenesis But Are Dispensable for Initial Specification of Precursor Cells

1997 • 286 citations

Mash2 Acts Cell Autonomously in Mouse Spongiotrophoblast Development

1997 • 219 citations

Preeclampsia: What we know and what we do not know

2000 • 203 citations

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

1999 • 188 citations

Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration

2000 • 138 citations

Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development

1998 • 124 citations

Requirement of the mouseI-mfagene for placental development and skeletal patterning

1998 • 110 citations

Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells

1995 • 77 citations

Intrauterine Oxygen Tension During the Estrous Cycle in the Rat: Its Relation to Uterine Respiration and Vascular Activity

1968 • 72 citations

Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast

1981 • 71 citations

Targeted mutagenesis: analysis of phenotype without germ line transmission.

1996 • 46 citations

On the control of the trophoblastic giant-cell transformation in the mouse: homotypic cellular interactions and polyploidy

1981 • 43 citations

Glucose metabolism in separated embryos and investing membranes during organogenesis in the rat

1994 • 36 citations

Preeclampsia Prevention and Management

2000 • 12 citations