Relationships between inhibition constants, inhibitor concentrations for 50% inhibition and types of inhibition: new ways of analysing data

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

4 Lactate Dehydrogenase

1975 • 1,272 citations

Enzymes: a practical introduction to structure, mechanism, and data analysis

2001 • 1,068 citations

A Comparison of Estimates of Michaelis-Menten Kinetic Constants from Various Linear Transformations

1965 • 1,060 citations

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)

1974 • 908 citations

Fundamentals of enzyme kinetics

1996 • 472 citations

High constitutive activity of native H3 receptors regulates histamine neurons in brain

2000 • 459 citations

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

2000 • 384 citations

Distinct pharmacology of rat and human histamine H₃ receptors: role of two amino acids in the third transmembrane domain

2000 • 147 citations

O-Methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase.

2000 • 93 citations

Calculation of inhibitor Ki and inhibitor type from the concentration of inhibitor for 50% inhibition for Michaelis-Menten enzymes

1987 • 79 citations

Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.

2000 • 74 citations

Deltorphin II-induced Rapid Desensitization of δ-Opioid Receptor Requires Both Phosphorylation and Internalization of the Receptor

2000 • 71 citations

Molecular impact of MinK on the enantiospecific block of I_Ks by chromanols

2000 • 66 citations

Study of the regulatory properties of glucokinase by site-directed mutagenesis: conversion of glucokinase to an enzyme with high affinity for glucose.

2000 • 46 citations

Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the β-agonist

2000 • 33 citations

Biochemical Characterization of the HIV-1 Integrase 3‘-Processing Activity and Its Inhibition by Phosphorothioate Oligonucleotides

1998 • 31 citations

Antagonist inhibition curves and the measurement of dissociation constants

1997 • 21 citations

Charge balance in the α‐hydroxyacid dehydrogenase vacuole: An acid test

1992 • 17 citations