Transforming Growth Factors

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

1975 • 747 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Transforming growth factor production by chemically transformed cells.

1981 • 506 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

1980 • 461 citations

Purification and initial characterization of a type beta transforming growth factor from human placenta.

1983 • 409 citations

Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.

1983 • 403 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Purification and properties of a type .beta. transforming growth factor from bovine kidney

1983 • 355 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Serum contains a platelet-derived transforming growth factor.

1982 • 330 citations

Transforming growth factors from neoplastic and nonneoplastic tissues.

1983 • 288 citations

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

1977 • 280 citations

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.

1982 • 263 citations

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation

1984 • 238 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.

1982 • 219 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF

1982 • 206 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Type beta transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval.

1985 • 191 citations

Purification of kidney epithelial cell growth inhibitors.

1980 • 174 citations

Mouse embryonic transforming growth factors related to those isolated from tumor cells.

1982 • 151 citations

Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor.

1983 • 148 citations

Type beta transforming growth factor from feline sarcoma virus-transformed rat cells. Isolation and biological properties.

1984 • 143 citations

Simian Sarcoma Virus—Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor

1984 • 137 citations

Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.

1982 • 137 citations

Comparison of intra- and extracellular transforming growth factors from nontransformed and chemically transformed mouse embryo cells.

1983 • 132 citations

High-molecular-weight transforming growth factor activity in the urine of patients with disseminated cancer.

1983 • 122 citations

Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.

1984 • 112 citations

Density-dependent regulation of growth of BSC-1 cells in cell culture: growth inhibitors formed by the cells.

1978 • 111 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

Liberation of Immunoreactive Somatomedin-C from Its Binding Proteins by Proteolytic Enzymes and Heparin*

1983 • 105 citations

Cellular responsiveness to growth factors correlates with a cell's ability to express the transformed phenotype

1983 • 100 citations

Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

1983 • 99 citations

Transforming growth factors in solid human malignant neoplasms.

1983 • 98 citations

05. Control of cell growth and proliferation

2005 • 95 citations

Differential effects of epidermal growth factor, transforming growth factor, and insulin on DNA and protein synthesis and morphology in serum-free cultures of AKR-2B cells.

1984 • 93 citations

Epithelial tissue-derived growth factor-like polypeptides.

1983 • 85 citations

Human term placenta contains transforming growth factors

1982 • 83 citations

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

1985 • 72 citations

Properties of a sarcoma‐growth‐factor‐like peptide from cells transformed by a temperature‐sensitive sarcoma virus

1981 • 71 citations

Identification of an epidermal growth factor-related transforming growth factor from rat fetuses

1982 • 61 citations

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

1982 • 60 citations

Activity of a kidney epithelial cell growth inhibitor on lung and mammary cells

1983 • 57 citations

Inability of anti-epidermal growth factor receptor monoclonal antibody to block “autocrine” growth stimulation in transforming growth factor-secreting melanoma cells.

1984 • 44 citations

Similar transforming growth factors (TGFs) produced by cells transformed by different isolates of feline sarcoma virus

1983 • 39 citations

Differential sensitivity of fibroblasts to epidermal growth factor is related to cyclic AMP concentration

1984 • 38 citations

Preparation and properties of a growth inhibitor produced by kidney epithelial cells

1983 • 26 citations

Isolation and partial purification of a new class of transforming growth factors from an avian sarcoma virus-transformed rat cell line.

1983 • 22 citations

Growth factors, growth factor receptors, and cell cycle control mechanisms in chemically transformed cells.

1982 • 21 citations

Autocrine secretion of peptide growth factors by tumor cells.

1982 • 21 citations

The purification of an acid‐ and heat‐labile transforming growth factor from an avian sarcoma virus‐ transformed rat cell line

1984 • 18 citations

Activities of transforming growth factors on cell lines and their modification by other growth factors.

1984 • 16 citations

Fibroblast Growth Factor stimulates anchorage independent growth in agar of BHK21/13 and SV3T3 cells

1982 • 5 citations