Essential Fatty Acids and Prostaglandins in Pregnancy

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Basic and Clinical Pharmacology

1982 • 2,009 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

A Study of Angiotensin II Pressor Response throughout Primigravid Pregnancy

1973 • 1,230 citations

TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION

1982 • 1,169 citations

A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

1929 • 1,140 citations

Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)

1997 • 1,090 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women

1994 • 965 citations

ON THE NATURE AND RÔLE OF THE FATTY ACIDS ESSENTIAL IN NUTRITION

1930 • 961 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Antiphospholipid antibody–associated recurrent pregnancy loss: Treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone

1996 • 807 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Hypertensive disorders in pregnancy

1985 • 668 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

physiology of human pregnancy

1971 • 621 citations

Preeclampsia: An imbalance in placental prostacyclin and thromboxane Production

1985 • 609 citations

The Physiology of Human Pregnancy

1965 • 583 citations

LOW-DOSE ASPIRIN PREVENTS PREGNANCY-INDUCED HYPERTENSION AND PRE-ECLAMPSIA IN ANGIOTENSIN-SENSITIVE PRIMIGRAVIDAE

1986 • 544 citations

Prevention of Preeclampsia with Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women

1993 • 528 citations

Biosynthesis of Prostaglandins

1991 • 503 citations

Hypertension and hyperuricaemia

1965 • 496 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

The enzymatic formation of prostaglandin E2 from arachidonic acid prostaglandins and related factors 32

1964 • 473 citations

On the specific vaso‐dilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin)

1936 • 452 citations

The Pregnant Diabetic and Her Newborn

1977 • 416 citations

Zur Kenntnis der pharmakologischen Wirkungen von Nativsekreten und Extrakten männlicher accessorischer Geschlechtsdrüsen

1934 • 403 citations

On the Mechanism of the Biosynthesis of Prostaglandins E1 and F1α

1967 • 403 citations

Hypotheses on physiological roles of prostaglandins.

1969 • 400 citations

On the Metabolism of Prostaglandins E1 and E2 in Man

1971 • 384 citations

The Use of Aspirin to Prevent Ppregnancy-Induced Hypertension and Lower the Ratio of Thromboxane A₂to Prostcyclin in Relatively High Risk Pregnancies

1989 • 377 citations

Properties of human seminal plasma

1935 • 361 citations

THERAPEUTIC ABORTION USING PROSTAGLANDIN F2α

1970 • 337 citations

The Isolation of Prostaglandin F from Sheep Prostate Glands.

1960 • 318 citations

Effect of Low-Dose Aspirin on Fetal and Maternal Generation of Thromboxane by Platelets in Women at Risk for Ppregnancy-Induced Hypertension

1989 • 318 citations

The enzymic conversion of all‐cis 8,11,14‐eicosatrienoic acid into prostaglandin E₁

1966 • 307 citations

Principles of medical pharmacology

1989 • 307 citations

Structure of leukotriene C identification of the amino acid part

1979 • 304 citations

Prostaglandins and Related Factors

1963 • 290 citations

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

1975 • 288 citations

Biochemical Studies of Human Semen. II. The Action of Semen on the Human Uterus.

1930 • 282 citations

Prostaglandin Synthetase Inhibitors I

1979 • 279 citations

Blockade of spontaneous and LH-induced ovulation in rats by indomethacin, an inhibitor of prostaglandin biosynthesis

1972 • 273 citations

Hypertensive Disorders in Pregnancy

1978 • 268 citations

Prednisone does not prevent recurrent fetal death in women with antiphospholipid antibody

1989 • 267 citations

Increased platelet thromboxane synthesis in diabetes mellitus.

1981 • 260 citations

The occurrence of two new prostaglandin derivatives (15-epi-PGA2 and its acetate, methyl ester) in the Gorgonian Chemistry of Coelenterates. XV.

1969 • 246 citations

The Isolation of Prostaglandin E from Sheep Prostate Glands.

1960 • 246 citations

Prenatal Magnesium Sulfate Exposure and the Risk for Cerebral Palsy or Mental Retardation Among Very Low-Birth-Weight Children Aged 3 to 5 Years

1996 • 240 citations

Prevention of Preeclampsia With Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women

1994 • 234 citations

On the Incorporation of Oxygen in the Conversion of 8,11,14-Eicosatrienoic Acid to Prostaglandin E₁

1965 • 231 citations

Lupus anticoagulant in pregnancy

1984 • 224 citations

Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia

1980 • 224 citations

Levels of prostaglandins in human endometrium during the normal menstrual cycle

1974 • 216 citations

Basic and clinical pharmacology

1990 • 211 citations

The inhibition of premature labor with indomethacin

1980 • 211 citations

Renin-angiotensin system in normal and toxemic pregnancies

1968 • 208 citations

Deficiency of essential fatty acids and membrane fluidity during pregnancy and lactation.

1991 • 207 citations

Biosynthesis of Prostaglandins from Arachidonic Acid in Guinea Pig Lung

1965 • 201 citations

Chronic Hyperinsulinemia in the Fetal Rhesus Monkey: Effects on Fetal Growth and Composition

1979 • 191 citations

Prostacyclin in pregnancy.

1980 • 187 citations

Prostaglandins and Related Factors

1964 • 187 citations

Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats.

1980 • 183 citations

Prostaglandins, cyclic nucleotides and cell function

1974 • 180 citations

Studies on prostaglandin; occurrence, formation and biological actions.

1959 • 179 citations

A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: Indications from a 50-year-old controlled trial

1990 • 179 citations

STUDIES IN THE INVOLVEMENT OF PROSTAGLANDINS IN UTERINE SYMPTOMATOLOGY AND PATHOLOGY

1976 • 178 citations

The Isolation of Prostaglandin.

1957 • 167 citations

Two Phases of Adipose Tissue Metabolism in Pregnancy: Maternal Adaptations for Fetal Growth1

1973 • 167 citations

The evils of delay.

1987 • 157 citations

The Effect of Prostaglandin

1972 • 154 citations

Factors Affecting the Secretion of Steroids from the Transplanted Ovary in the Sheep

1971 • 154 citations

The Contractile Response of the Human Uterus, Fallopian Tubes, and Ovary to Prostaglandins in Vivo

1971 • 153 citations

Appearance of Prostaglandin F2 in Human Blood during Labour

1968 • 151 citations

Essential fatty acid requirements in pregnancy and lactation with special reference to brain development

1981 • 148 citations

Enzymatic Conversion of All-cis-Polyunsaturated Fatty Acids into Prostaglandins

1964 • 147 citations

Quantitative gas chromatography of prostaglandin E1 at the nanogram level: Use of deuterated carrier and multiple-ion analyzer

1970 • 147 citations

Initiation of human parturition

1982 • 146 citations

The Relation Between Fertility and Prostaglandin Content of Seminal Fluid in Man

1970 • 145 citations

Leukotrienes: a new group of biologically active compounds.

1980 • 142 citations

Magnesium sulfate: rationale for its use in preeclampsia.

1986 • 141 citations

Prostaglandins and the regulation of uterine blood flow in pregnancy

1974 • 137 citations

Specificity in the enzymic conversion of polyunsaturated fatty acids into prostaglandins

1966 • 137 citations

Properties of a novel preparation of prostaglandin synthetase from sheep seminal vesicles

1971 • 135 citations

E PROSTAGLANDINS IN AMNIOTIC FLUID DURING LATE PREGNANCY AND LABOUR

1973 • 131 citations

Initiation of human parturition. I. Mechanism of action of arachidonic acid.

1974 • 128 citations

Prostaglandins and the Kidney

1973 • 127 citations

Direct Evidence for a Prostaglandin Receptor and Its Application to Prostaglandin Measurements

1972 • 125 citations

Alteration of Vein Cyclic 3′:5′ Nucleotide Concentrations During Changes in Contractility

1974 • 124 citations

ACTION OF PROSTAGLANDIN IN THE PREGNANT WOMAN

1971 • 123 citations

Analyses of prostaglandins in human semen prostaglandins and related factors 44

1966 • 121 citations

SUBCUTANEOUS FAT IN NEWBORN INFANTS OF DIABETIC MOTHERS: AN INDICATION OF QUALITY OF DIABETIC CONTROL

1977 • 121 citations

Placental prostacyclin production in normal and toxemic pregnancies

1985 • 118 citations

PROSTAGLANDINS FOR INDUCTION OF THERAPEUTIC ABORTION

1970 • 116 citations

Luteolytic Effects of Prostaglandin F2 in Primates

1970 • 112 citations

Prostaglandins, indomethacin and dysmenorrhea

1976 • 102 citations

IDENTIFICATION OF PROSTAGLANDINS IN HUMAN AMNIOTIC FLUID

1966 • 100 citations

F PROSTAGLANDINS IN AMNIOTIC FLUID DURING PREGNANCY AND LABOUR

1974 • 99 citations

Possible Role for Prostaglandin F2α in Parturition in Sheep

1971 • 95 citations

Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor; A randomized study

1990 • 94 citations

Prostacyclin (PGI2) in pregnant human uterus

1979 • 94 citations

Prostaglandin F_2α Receptor in Ovine corpora lutea

1974 • 93 citations

Effects of Prostaglandins on Oviductal Motility and Egg Transport

1975 • 93 citations

Initiation of parturition in the human female.

1978 • 93 citations

On the Metabolism of Prostaglandin F2alpha in Female Subjects. Structures of Two Metabolites in Blood

1972 • 88 citations

The leukotrienes: a new group of biologically active compounds including SRS-A

1980 • 86 citations

Initiation of human parturition

1978 • 86 citations

Pre and post ovulatory changes in the concentration of prostaglandins in rat Graafian follicles

1975 • 83 citations

PROSTAGLANDIN-F2α RECEPTOR IN HUMAN CORPORA LUTEA

1974 • 76 citations

EFFECTS OF PROSTAGLANDIN F2α AND E2 ON THE PRODUCTION OF PROGESTERONE BY HUMAN GRANULOSA CELLS IN TISSUE CULTURE

1975 • 76 citations

Initiation of human parturition. III. Fetal membrane content of prostaglandin E2 and F2alpha precursor.

1975 • 75 citations

Occurrence and Properties of a Prostaglandin F_2α Receptor in Bovine Corpora Lutea

1975 • 73 citations

Radioimmunoassay of prostaglandins

1978 • 73 citations

The Effect of Prostaglandin E₂ and E₃ on the Human Uterus and the Fallopian Tubes in Vitro

1964 • 69 citations

The separation, identification and estimation of prostaglandins in nanogram quantities by combined gas chromatography-mass spectrometry

1970 • 68 citations

Possible role for prostacyclin in human parturition

1978 • 66 citations

CONCENTRATIONS OF PROSTAGLANDIN F_2α IN AMNIOTIC FLUID AND PLASMA IN SPONTANEOUS AND INDUCED LABOURS

1974 • 66 citations

Low-Dose Aspirin in Pregnancy

1990 • 65 citations

Serum arachidonic acid levels in normal and preeclamptic pregnancies

1984 • 65 citations

6-Keto prostaglandin F1α, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period

1985 • 65 citations

Adjunctive use of magnesium sulfate with ritodrine for preterm labor tocolysis

1984 • 60 citations

The determination of prostaglandin metabolites in human urine.

1975 • 57 citations

The participation of molecular oxygen in the biosynthesis of prostaglandins

1965 • 57 citations

Prostaglandin Synthetase Inhibitors

1981 • 57 citations

The Prostaglandins: Clinical Applications in Human Reproduction

1973 • 56 citations

Plasma Prostaglandin Levels in Rats with Diabetes Mellitus and Diabetic Ketoacidosis

1982 • 56 citations

The Prostaglandins: Progress In Research

1973 • 56 citations

THE PLASMA FREE FATTY ACID COMPOSITION AND BLOOD GLUCOSE OF NORMAL AND DIABETIC PREGNANT WOMEN AND OF THEIR NEWBORNS

1965 • 55 citations

Initiation of human parturition

1975 • 54 citations

The origin of oxygen incorporated during the biosynthesis of prostaglandin E1

1965 • 54 citations

Fatty acid content of yolk sac and embryo in hyperglycemia-induced embryopathy and effect of arachidonic acid supplementation

1988 • 54 citations

Prostacyclin: its biosynthesis, actions, and clinical potential.

1982 • 53 citations

Radioimmunoassays for prostaglandin metabolites.

1976 • 53 citations

Fatty acyl Δ6 desaturation activity of cultured human endothelial cells modulation by fetal bovine serum

1983 • 52 citations

Prostaglandin metabolism in the fetal and maternal vasculature.

1979 • 51 citations

INCREASE OF THE PROSTAGLANDIN PRECURSOR, ARACHIDONIC ACID, IN AMNIOTIC FLUID DURING SPONTANEOUS LABOUR

1977 • 51 citations

Plasmatic regulation of vascular prostacyclin in pregnancy.

1981 • 50 citations

DYSMENORRHEA AND PROSTAGLANDINS

1976 • 49 citations

Effect of low-dose aspirin on angiotensin II pressor response in human pregnancy

1987 • 49 citations

STUDIES ON THE TOTAL SYNTHESIS OF PROSTAGLANDINS

1971 • 48 citations

Prostacyclin producing activity of human umbilical, placental and uterine vessels

1983 • 48 citations

Prolongation of premature gestation in women with hemolysis, elevated liver enzymes and low platelets. A report of five cases.

1990 • 48 citations

Initiation of human parturition. IV. Demonstration of phospholipase A2 in the lysosomes of human fetal membranes.

1976 • 47 citations

Selective effects of isomeric cis and trans fatty acids on fatty acyl Δ9 and Δ6 desaturation by human skin fibroblasts

1983 • 47 citations

The Effect of Prostaglandin F_1α, F_1β, F_2α, and F_2β, on the Human Uterus and the Fallopian Tubes in Vitro

1965 • 47 citations

Prostaglandins and cardiovascular disease

1981 • 46 citations

Plasma prostanoids in pregnancy‐induced hypertension

1982 • 45 citations

Increased synthesis of prostaglandin endoperoxides and platelet hyperfunction in infants of mothers with diabetes mellitus.

1979 • 45 citations

Insulin and arachidonic acid metabolism in diabetes mellitus

1985 • 44 citations

PROSTAGLANDIN INDUCTION OF LUTEOLYSIS

1971 • 43 citations

Control of Human Fertility.

1970 • 42 citations

Synthesis of prostaglandins by the ductus arteriosus of the bovine fetus

1977 • 41 citations

Prevention of Preterm Birth

1988 • 40 citations

Comparison of platelet thromboxane synthesis in diabetic patients on conventional insulin therapy and continuous insulin infusions

1982 • 40 citations

Correlation of prostacyclin synthesis by human umbilical artery with status of essential fatty acid

1984 • 39 citations

Prostaglandin F2 Concentrations in Peripheral Blood During the First Stage of Normal Labour

1973 • 38 citations

The enzymic conversion of arachidonic acid to prostaglandin E2 with acetone powder preparations of bovine seminal vesicles

1965 • 37 citations

Research in Reproduction

1972 • 35 citations

Initiation of human parturition

1976 • 35 citations

LIPID METABOLISM IN THE FETUS DURING DEVELOPMENT

1970 • 34 citations

The Biosynthesis of Prostaglandin E1 Studied with Specifically 3H-Labelled 8,11,14-Eicosatrienoic Acids.

1965 • 33 citations

The stimulatory effect of prostaglandins on luteinizing hormone release

1974 • 33 citations

Synthesis of Arachidonic Acid in the Human Placenta <i>in vitro</i>

1979 • 32 citations

Effect of exogenous estradiol and progesterone on the uterine tissue levels of prostaglandin F2α (PGF2α) in ovariectomized mice

1973 • 31 citations

Prostaglandins: physiology, biochemistry, pharmacology and clinical applications

1978 • 30 citations

Prostaglandin receptors in the hamster uterus during the estrous cycle

1973 • 27 citations

Slow-Reacting Substance of Anaphylaxis: Studies on Purification and Characterisation

1979 • 27 citations

Total Serum Fatty Acids in Diabetes

1968 • 26 citations

Immunoreactive prostacyclin and thromboxane metabolites in normal pregnancy and the puerperium

1985 • 26 citations

Diabetes Mellitus in Pregnancy: Principles and Practice

1989 • 26 citations

Diabetes mellitus in pregnancy : principles and practice

1988 • 25 citations

The prostaglandins: clinical applications in human reproduction

1972 • 24 citations

Conversion of homo-γ-linolenic acid to prostaglandin F1α by ovine and bovine seminal vesicle extracts

1965 • 24 citations

Enhanced Fatty Acid Synthesis in Hyperinsulinemic Rat Fetuses

1983 • 23 citations

Vascular responsiveness to pressor agents during human pregnancy.

1979 • 21 citations

Thromboxane biosynthesis in platelets of diabetic and coronary artery diseased patients.

1982 • 20 citations

Observations on the Pathogenesis of Reyeʼs Syndrome

1971 • 20 citations

Prostaglandins from bedside observation to a family of drugs

1981 • 17 citations

Prostaglandins, the Glucoreceptor, and Diabetes

1979 • 17 citations

EFFECTS OF INDOMETHACIN, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE HYPOTHALAMIC-PITUITARY SYSTEM IN RATS

1975 • 15 citations

Maternal plasma levels of 6-keto-prostaglandin f1α during pregnancy and puerperium

1981 • 15 citations

Developmental responses to oxygen, arachidonic acid, and indomethacin in the fetal lamb ductus arteriosus

1978 • 15 citations

Abnormalities in vascular arachidonic acid metabolism in the infant of the diabetic mother.

1985 • 15 citations

Essential Fatty Acids in Nutrition and Metabolism

1960 • 13 citations

Arachidonic acid and other free fatty acid changes during abortion induced by prostaglandin F2α

1978 • 11 citations

Recent aspects on systemic administration of prostaglandin.

1972 • 10 citations

Prostaglandins and Reproduction in Sub-Human Primates

1972 • 10 citations

Primary prostaglandins in human peripheral plasma by radioimmunoassay.

1976 • 9 citations

Prolonged hyperinsulinemia reduces plasma fatty acid levels in the major lipid groups in fetal sheep

1989 • 8 citations

Gonadal Function

1973 • 7 citations

Effects of chronic fetal hyperinsulinemia on plasma arachidonic acid and prostaglandin concentrations

1989 • 7 citations

Insulin, Glucosetoleranz und freie Fetts�uren w�hrend und nach akuter Hepatitis

1970 • 7 citations

Effect of prostaglandin F2α on the luteal phase of the cycle in nonpregnant women

1974 • 7 citations

PRETERM LABOR

1988 • 6 citations

Ovarian contractility and ovulation.

1974 • 5 citations

The prostaglandins: biology and biochemistry.

1972 • 5 citations

Prostaglandins in reproduction.

1978 • 4 citations

Preeclampsia and essential fatty acid patterns

1986 • 4 citations

Effects of oxytocin on nonesterified fatty acids.

1971 • 3 citations

Possible Involvement of Kinins and Prostaglandins in the Translation of Insulin Action on Glucose Uptake into Skeletal Muscle

1979 • 3 citations

Essential fatty acid patterns in preeclampsia.

1986 • 3 citations

The Prostaglandins in Human Reproduction: Clinical Applications

1976 • 2 citations

The prostaglandins in human reproduction : clinical applications

1975 • 2 citations

Deleted Work

1955 • 0 citations