The calpains

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation

1987 • 340 citations

Calcium‐dependent proteases: an enzyme system active at cellular membranes?

1987 • 308 citations

EXTRALYSOSOMAL PROTEIN DEGRADATION

1986 • 279 citations

Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function

1987 • 273 citations

Anti-α-fodrin inhibits secretion from permeabilized chromaffin cells

1987 • 184 citations

Distribution of calpains I and II in rat brain

1986 • 183 citations

Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve

1979 • 183 citations

Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

1981 • 180 citations

Calcium activated neutral protease: domain structure and activity regulation

1987 • 168 citations

Calpain II Involvement in Mitosis

1988 • 163 citations

Characterization of a brain calcium-activated protease that degrades neurofilament proteins

1982 • 160 citations

Effect of L-alpha-phosphatidylinositol on a vascular smooth muscle Ca2+-dependent protease. Reduction of the Ca2+ requirement for autolysis.

1984 • 156 citations

The calmodulin-binding site in alpha-fodrin is near the calcium-dependent protease-I cleavage site.

1988 • 150 citations

Regulation of glutamate receptors by cations

1979 • 149 citations

Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus

1988 • 147 citations

Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules

1988 • 130 citations

Properties of a calcium‐activated protease in squid axoplasm which selectively degrades neurofilament proteins

1980 • 126 citations

Regulation of glutamate receptor binding by the cytoskeletal protein fodrin

1985 • 116 citations

Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain

1985 • 92 citations

Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C.

1988 • 85 citations

A possible physiological role of the Ca-dependent protease calpain and its inhibitor calpastatin on the Ca current in guinea pig myocytes

1988 • 85 citations

Identification of Ca²⁺‐Activated Neutral Protease in the Peripheral Nerve and Its Effects on Neurofilament Degeneration

1983 • 82 citations

Identification and partial purification of a factor that stimulates calcium-dependent proteases

1982 • 81 citations

Autoproteolysis of the small subunit of calcium-dependent protease II activates and regulates protease activity.

1986 • 79 citations

Fragmentation of an endogenous inhibitor upon complex formation with high- and low-calcium requiring forms of calcium-activated neutral proteases

1989 • 77 citations

Fodrin degradation by calcium-activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: preferential localization of CANP activities in neurons

1986 • 73 citations

Binding to erythrocyte membrane is the physiological mechanism for activation of Ca2+-dependent neutral proteinase

1985 • 70 citations

Activation mechanism of calcium-activated neutral protease. Evidence for the existence of intramolecular and intermolecular autolyses.

1988 • 70 citations

Following association to the membrane, human erythrocyte procalpain is converted and released as fully active calpain

1985 • 58 citations

A Calcium‐Activated Protease which Preferentially Degrades the 160‐kDa Component of the Neurofilament Triplet

1983 • 56 citations

Enhanced activation of the respiratory burst oxidase in neutrophils from hypertensive patients

1989 • 48 citations

Calcium ATPase in Erythrocytes of Spontaneously Hypertensive Rats of the Milan Strain

1985 • 48 citations

A calcium‐protease activator associated with brain microsomal‐insoluble elements

1986 • 46 citations

The role of subunit autolysis in activation of smooth muscle Ca2+-dependent proteases.

1986 • 45 citations

On the mechanism of binding of calpastatin, the protein inhibitor of calpains, to biologic membranes

1988 • 25 citations

Isovalerylcarnitine is a specific activator of calpain of human neutrophils

1987 • 23 citations

Isolated bovine myocardial sarcolemma and sarcoplasmic reticulum vesicles contain tightly bound calcium-dependent protease inhibitor

1987 • 22 citations

Proteolysis of the protein inhibitor of calcium-dependent proteases produces lower molecular weight fragments that retain inhibitory activity

1988 • 21 citations

Characterization of the defective calpain-endogenous calpain inhibitor system in erythrocytes from Milan hypertensive rats

1986 • 19 citations

Favism: impairment of proteolytic systems in red blood cells

1987 • 16 citations