Collagen Biosynthesi

A Possible Precursor of Immunoglobulin Light Chains

1972 • 609 citations

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen

1973 • 563 citations

New Hypothesis of Insulin Secretion

1968 • 539 citations

A Cytochemical Study on the Pancreas of the Guinea Pig

1960 • 430 citations

The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts

1972 • 377 citations

SYNTHESIS, MIGRATION, AND RELEASE OF PRECURSOR COLLAGEN BY ODONTOBLASTS AS VISUALIZED BY RADIOAUTOGRAPHY AFTER [3H]PROLINE ADMINISTRATION

1974 • 376 citations

An autoradiographic and electron microscopic study of collagen synthesis in differentiating cartilage

1963 • 367 citations

WOUND HEALING AND COLLAGEN FORMATION

1965 • 298 citations

Evidence for the Linkage of a Disaccharide to Hydroxylysine in Tropocollagen

1966 • 298 citations

Collagen Made of Extended alpha-Chains, Procollagen, in Genetically-Defective Dermatosparaxic Calves

1971 • 294 citations

Synthesis of (Pro-Hyp-Gly)n of defined molecular weights Evidence for the stabilization of collagen triple helix by hydroxypyroline

1973 • 291 citations

Characterization and Quantitative Determination of the Hydroxylysine-linked Carbohydrate Units of Several Collagens

1969 • 289 citations

Isolation of a collagen from basement membranes containing three identical α-chains

1971 • 287 citations

Synthesis and extrusion of collagen by freshly isolated cells from chick embryo tendon

1971 • 280 citations

Ribosome-Membrane Interaction in Eukaryotic Cells

1971 • 278 citations

SOME ASPECTS OF THE METABOLISM OF HYDROXYPROLINE, STUDIED WITH THE AID OF ISOTOPIC NITROGEN

1949 • 277 citations

Synthesis and Transfer of Amylase in Pigeon Pancreatic Microsomes

1966 • 272 citations

Inhibition of Collagen Secretion from Bone and Cultured Fibroblasts by Microtubular Disruptive Drugs

1972 • 266 citations

Action of Proteolytic Enzymes on Tropocollagen and Insoluble Collagen^*

1966 • 258 citations

The Amino Acid Composition of Some Fish Collagens: The Relation between Composition and Structure

1960 • 240 citations

The Nature of the Collagen Synthesized by Cultured Human Fibroblasts

1971 • 238 citations

Procollagen Peptidase: An Enzyme Excising the Coordination Peptides of Procollagen

1971 • 232 citations

Hydroxyproline content determines the denaturation temperature of chick tendon collagen

1973 • 224 citations

Hydroxyproline stabilizes the triple helix of chick tendon collagen

1973 • 201 citations

Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine

1972 • 197 citations

Microtubules in Transcellular Movement of Procollagen

1972 • 194 citations

Evidence for Procollagen, a Biosynthetic Precursor of Collagen

1971 • 193 citations

Isolation and Characterization of the Cyanogen Bromide Peptides from the α1 Chain of Rat Skin Collagen^*

1967 • 187 citations

A hypothesis on the role of hydroxyproline in stabilizing collagen structure

1973 • 186 citations

Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen

1966 • 180 citations

Conversion of Proline to Collagen Hydroxyproline in a Cell-free System from Chick Embryo

1963 • 180 citations

SECRETION OF COLLAGEN BY CORNEAL EPITHELIUM

1973 • 179 citations

Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients

1971 • 179 citations

THE METABOLISM OF l(-)-PROLINE STUDIED WITH THE AID OF DEUTERIUM AND ISOTOPIC NITROGEN

1944 • 176 citations

Affinity Column Purification of Protocollagen Proline Hydroxylase from Chick Embryos and Further Characterization of the Enzyme

1973 • 168 citations

Hydroxylation of Proline in Synthetic Polypeptides with Purified Protocollagen Hydroxylase

1967 • 167 citations

THE SECRETORY PATHWAYS OF RAT SERUM GLYCOPROTEINS AND ALBUMIN

1972 • 154 citations

Purification and properties of collagen proline hydroxylase from newborn rat skin

1970 • 152 citations

Further evidence for a transport form of collagen. Its extrusion and extracellular conversion to tropocollagen in embryonic tendon

1971 • 135 citations

Incorporation of proline analogues into collagen polypeptides Effects on the production of extracellular procollagen and on the stability of the triple-helical structure of the molecule

1974 • 134 citations

ON THE ACTION OF COLCHICINE

1965 • 131 citations

SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN

1965 • 130 citations

Hydroxylation of proline residues in collagen nascent chains

1970 • 129 citations

Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.

1968 • 127 citations

The Function of Hydroxyproline in Collagens

1955 • 127 citations

The Biosynthesis of Basement Membrane Collagen in Embryonic Chick Lens

1972 • 121 citations

Purification of carbon-14-labeled protocollagen and its hydroxylation by prolyl-hydroxylase

1973 • 120 citations

Influence of chelating agents on the biosynthesis of collagen

1965 • 119 citations

STUDIES ON CARTILAGE

1962 • 119 citations

VACUOLES IN THE EMBRYONIC CHICK CORNEAL EPITHELIUM, AN EPITHELIUM WHICH PRODUCES COLLAGEN

1971 • 114 citations

Incorporation of 18O from air into hydroxyproline by chick embryo

1962 • 113 citations

Production of Procollagen by Human Fibroblasts in Culture

1972 • 105 citations

Collagen Synthesis: Localization of Prolyl Hydroxylase in Tendon Cells Detected with Ferritin-Labeled Antibodies

1973 • 105 citations

Intracellular Collagen and Protocollagen from Embryonic Tendon Cells

1973 • 103 citations

The thermal denaturation of collagen in solution and its structural implications

1959 • 103 citations

A Kinetic Study of Collagen Biosynthesis

1972 • 102 citations

Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells

1974 • 102 citations

A Comparative Study of Glycopeptides Derived from Selected Vertebrate Collagens

1970 • 101 citations

A Transport Form of Collagen from Embryonic Tendon: Electron Microscopic Demonstration of an NH ₂ -Terminal Extension and Evidence Suggesting the Presence of Cystine in the Molecule

1972 • 98 citations

The Biosynthesis of Basement Membrane Collagen in Embryonic Chick Lens

1973 • 95 citations

Precursors of Collagen Secreted by Cultured Human Fibroblasts

1972 • 95 citations

Collagen chain formation and peptidyl proline hydroxylation in monolayer tissue cultures of L-929 fibroblasts

1969 • 95 citations

Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase

1968 • 92 citations

Incorporation of cis-Hydroxyproline into Protocollagen and Collagen

1971 • 91 citations

Partial purification and characterization of protocollagen lysine hydroxylase from chick embryos

1972 • 90 citations

THE GOLGI APPARATUS IN CHICK CORNEAL EPITHELIUM: CHANGES IN INTRACELLULAR POSITION DURING DEVELOPMENT

1970 • 89 citations

The Biosynthesis of Basement Membrane Collagen in Embryonic Chick Lens

1972 • 88 citations

Characterization of the Pro-α1 Chain of Procollagen

1972 • 87 citations

Effect of Lactate on Collagen Proline Hydroxylase Activity in Cultured L-929 Fibroblasts

1970 • 87 citations

Activation of Prolyl Hydroxylase in L-929 Fibroblasts by Ascorbic Acid

1973 • 86 citations

Proposed Mechanism for the Biological Assembly of Collagen Triple Helix

1971 • 85 citations

Cell-free Collagen Synthesis on Membrane-bound Polysomes of Chick Embryo Connective Tissue and the Localization of Prolyl Hydroxylase on the Polysome-Membrane Complex

1973 • 85 citations

Collagen synthesis on polyribosomes of cultured mammalian fibroblasts

1967 • 84 citations

Protocollagen lysine hydroxylase. Hydroxylation of synthetic peptides and the stoichiometric decarboxylation of α-ketoglutarate

1972 • 83 citations

Procollagen: Conversion of the Precursor to Collagen by a Neutral Protease

1972 • 80 citations

THE CONVERSION OF LYSINE TO HYDROXYLYSINE AND ITS RELATION TO THE BIOSYNTHESIS OF COLLAGEN IN SEVERAL TISSUES OF THE RAT

1957 • 79 citations

Oxygen-18 studies on the conversion of proline to collagen hydroxyproline

1963 • 79 citations

Incorporation of 3,4-Dehydroproline into Protocollagen and Collagen

1970 • 77 citations

THE SOURCE AND STATE OF THE HYDROXYLYSINE OF COLLAGEN

1955 • 75 citations

Synthetic polypeptides as substrates and inhibitors of collagen proline hydroxylase

1968 • 75 citations

Effect of an Additional Peptide Extension of the N‐Terminus of Collagen from Dermatosparactic Calves on the Cross‐Linking of the Collagen Fibres

1973 • 75 citations

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo I. Arrest of collagen accumulation in growing chick embryos

1971 • 75 citations

INTRACELLULAR ACCUMULATION OF PROTOCOLLAGEN AND EXTRUSION OF COLLAGEN BY EMBRYONIC CARTILAGE CELLS

1968 • 75 citations

Actions of Insulin and Growth Hormone on Collagen and Chondroitin Sulfate Synthesis in Bone Organ Cultures

1969 • 74 citations

Synthesis of Collagen on Polyribosomes

1964 • 74 citations

Collagen Biosynthesis: Synthesis and Secretion of a High Molecular Weight Collagen Precursor (Procollagen)

1971 • 74 citations

H³‐proline incorporation into cartilage: Electron microscope autoradiographic observations

1968 • 74 citations

Regulation of collagen secretion by ascorbic acid in 3T3 and chick embryo fibroblasts

1972 • 72 citations

Secretion and Extracellular Processing of Procollagen by Cultured Human Fibroblasts

1973 • 71 citations

Studies on protocollagen: Identification of a precursor of proto α1

1971 • 68 citations

Isolation and characterization of cyanogen bromide peptides from basement membrane collagen

1972 • 68 citations

Procollagen: Intermediate Forms Containing Several Types of Peptide Chains and Non-Collagen Peptide Extensions at NH ₂ and COOH Ends

1974 • 68 citations

Incorporation of cis-hydroxyproline into collagen by tendon cells. Failure of the intracellular collagen to assume a triple-helical conformation

1972 • 68 citations

Glycoprotein biosynthesis: The biosynthesis of the hydroxylysine-galactose linkage in collagen

1968 • 68 citations

Collagen and Procollagen Production by a Clonal Line of Schwann Cells

1973 • 68 citations

Chemical properties of the peptide extension in the pα 1 chain of dermatosparactic skin procollagen

1972 • 67 citations

Inhibition of proline and lysine hydroxylation prevents normal extrusion of collagen by 3T6 fibroblasts in culture

1971 • 67 citations

Collagen polysomes: Site of hydroxylation of proline residues

1971 • 66 citations

The Source and State of the Hydroxylysine of Collagen

1959 • 66 citations

The activation of protocollagen proline hydroxylase by ascorbic acid in cultured 3T6 fibroblasts

1974 • 64 citations

Kinetic patterns of protocollagen hydroxylase and further studies on the polypeptide substrate

1968 • 62 citations

Electronoptical studies of procollagen from the skin of dermatosparaxic calves

1971 • 61 citations

Collagen Synthesis on Polysomes in vivo and in vitro

1971 • 60 citations

The synthesis of underhydroxylated collagen by 3T6 mouse fibroblasts in culture

1972 • 60 citations

Hydroxylation of lysyl residues in collagen by protocollagen lysyl hydroxylase in vitro

1973 • 59 citations

Immunological Evidence for an Inactive Precursor of Collagen Proline Hydroxylase in Cultured Fibroblasts

1971 • 58 citations

Identification of a Disulfide-Linked Procollagen as the Biosynthetic Precursor of Chick-Bone Collagen

1973 • 57 citations

Isolation of a Disulfide-stabilized, Three-Chain Polypeptide Fragment Unique to the Precursor of Human Collagen

1973 • 56 citations

The role of hydroxylation in the secretion of collagen by mouse fibroblasts in culture

1971 • 55 citations

Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase Effect of chain length, helical conformation and amino acid sequence in the substrate

1972 • 54 citations

Comparison of Collagen Dynamics in Different Tissues Under the Influence of Estradiol

1973 • 52 citations

Characterization of the Proα1 Chain of Procollagen

1973 • 50 citations

Further study on the activation of collagen proline hydroxylase in cultures of L-929 fibroblasts

1970 • 49 citations

The effect of ascorbic acid on the synthesis of collagen precursor secreted by 3T6 mouse fibroblasts in culture

1972 • 49 citations

Identification of Two Distinct Species of Procollagen synthesized by a Clonal Line of Calf Dermatosparactic Cells

1973 • 48 citations

Protocollagen proline hydroxylase: Molecular weight, subunits and isoelectric point

1970 • 46 citations

Evidence for an Amino-Terminal Extension in High-Molecular-Weight Collagens from Mature Bovine Skin

1973 • 45 citations

The sub-cellular location of inter-chain disulfide bond formation during procollagen biosynthesis by embryonic chick tendon cells

1973 • 43 citations

The Incomplete Hydroxylation of Individual Prolyl Residues in Collagen

1967 • 43 citations

The production and secretion of procollagen peptidase by human fibroblasts in culture

1973 • 43 citations

The self‐assembly of collagen molecules

1973 • 42 citations

Collagen Synthesis: A Disulfide-Linked Collagen Precursor in Chick Bone

1973 • 40 citations

Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo II. Morphological and physical properties of collagen containing the analogue

1971 • 39 citations

Chromatographic separation of the enzymes required for hydroxylation of lysine and proline residues of protocollagen

1971 • 38 citations

High-molecular-weight α chains in acid-soluble collagen and their role in fibrillogenesis

1972 • 38 citations

Evidence for free radical involvement in the hydroxylation of proline: Inhibition by nitro blue tetrazolium

1972 • 37 citations

The Presence of Fucose, Mannose, and Glucosamine-containing Heteropolysaccharide in Collagen from the Sea Anemone Metridium dianthus

1972 • 37 citations

Metabolism by isolated fibroblasts of abnormal collagens containing analogues of proline or lysine

1972 • 37 citations

The molecular parameters of monomeric and acid‐soluble collagens. Low shear gradient viscosity and electric birefringence

1972 • 36 citations

Ascorbate-dependent differences in the hydroxylation of proline and lysine in collagen synthesized by 3T6 fibroblasts in culture

1972 • 36 citations

Collagen synthesis by cells II: Secretion of a disulfide linked material

1972 • 34 citations

Association of prolyl hydroxylase activity with membranes

1973 • 34 citations

Determination of the Glycosylated Hydroxylysines in Several Invertebrate Collagens

1972 • 33 citations

Evidence that chick tendon procollagen must be denatured to serve as substrate for proline hydroxylase (Short Communication)

1973 • 33 citations

The enzymic hydroxylation of protocollagen models

1969 • 31 citations

Structure of Protocollagen Proline Hydroxylase from Chick Embryos

1973 • 30 citations

Partial purification and properties of collagen lysine hydroxylase from chick embryos

1972 • 30 citations

Conformation of underhydroxylated collagen synthesized by 3T6 fibroblasts in culture

1973 • 28 citations

High molecular weight collagen: A long-lived intermediate in the biogenesis of collagen fibrils

1972 • 28 citations

Further characterization of procollagen: The identification of a pro-α2 chain

1972 • 27 citations

The Formation of Collagen α Chains in the Absence of Proline Hydroxylation

1970 • 26 citations

Labeled antibodies to protocollagen proline hydroxylase from chick embryos for intracellular localization of the enzyme

1972 • 25 citations

The effect of ascorbic acid on the cross-linking of collagen during its synthesis by cultured 3T6 fibroblasts

1972 • 25 citations

In Vitro Enzymatic Hydroxylation of Prolyl Residues in the α1-CB2 Fragment of Rat Collagen

1971 • 25 citations

The C-Terminal Non-Helical Portion of the Collagen Molecule

1973 • 25 citations

Characterization of the precursor forms of the α1 and α2 chains of collagen from matrix-free tendon cells

1972 • 25 citations

Serotonin and Ribonucleic Acid and Collagen Metabolism of Fibroblasts in Vitro

1972 • 23 citations

Independence of collagen hydroxylation on the conformational state of the precursor substrate

1968 • 23 citations

Studies on the synthesis and intracellular accumulation of protocollagen in organ culture of embryonic cartilage

1968 • 22 citations

Antibodies to a Precursor of Human Collagen

1973 • 22 citations

A Long-Term Effect of Insulin on Collagen Synthesis by Newborn Rat Bone in Vitro

1970 • 20 citations

A general method for the rapid measurement of enzyme precursors by the displacement of enzyme from antibody: The measurement of collagen proline hydroxylase precursor in cultured fibroblasts

1972 • 20 citations

Inhibition of collagen synthesis by α, α′-dipyridyl in human skin fibroblasts in culture

1973 • 20 citations

Die Einwirkung von proteolytischen Enzymen auf unl�sliches Kollagen

1963 • 19 citations

Effects of Incorporation of trans-4,5-Dehydrolysine on Collagen Biosynthesis and Extrusion in Embryonic Chick Tibiae

1971 • 19 citations

LSD-25 Does Not Intercalate in DNA

1971 • 16 citations

THE "SPINDLE-SHAPED BODY" IN FIBROBLASTS

1964 • 15 citations

In vitro Incorporation and Hydroxylation of Lysine-2-C14 In Rat Biopsy-Connective Tissue.

1958 • 9 citations

The in Vitro Effect of Insulin on Collagen Synthesis in Embryonic Chick Tibia

1973 • 9 citations

Growth hormone inhibition of proline hydroxylation in vitro

1971 • 4 citations

Ultracentrifugation as a probe of conformation of unhydroxylated procollagen and collagen

1974 • 4 citations