Engineering Novel, Prolonged-Acting Insulins

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

1987 • 1,275 citations

Mechanism of C-terminal amide formation by pituitary enzymes

1982 • 658 citations

Monomeric insulins obtained by protein engineering and their medical implications

1988 • 493 citations

A Simple Free Fat Cell Bioassay for Insulin

1974 • 365 citations

Absorption of Injected Insulin

1969 • 288 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Galenics of Insulin

1987 • 192 citations

Three-Dimensional Atomic Structure of Insulin and Its Relationship to Activity

1972 • 134 citations

The biological activity and the binding affinity of modified insulins determined on isolated rat fat cells

1974 • 133 citations

Separation and Characterization of Acid-induced Insulin Transformation Products by Paper Electrophoresis in 7 m Urea

1962 • 119 citations

Variation in125i-insulin absorption and blood glucose concentration

1979 • 113 citations

Soluble, prolonged-acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27 and B30

1988 • 94 citations

Single chain des-(B30) insulin. Intramolecular crosslinking of insulin by trypsin catalyzed transpeptidation.

1985 • 69 citations

Soluble, prolonged-acting insulin derivatives. II. Degree of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30

1987 • 65 citations

Single chain des‐(B30) insulin

1985 • 64 citations

Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and crystallizability of insulins substituted in the termini of the B-chain

1987 • 50 citations

Comparative reduction/oxidation studies with single chain des‐(B30) insulin and porcine proinsulin

1985 • 39 citations

Pharmacokinetic and clinical aspects of intensified subcutaneous insulin therapy.

1985 • 32 citations

Development of insulin antibodies, metabolic control and B-cell function in newly diagnosed insulin dependent diabetic children treated with monocomponent human insulin or monocomponent porcine insulin.

1988 • 29 citations

Human Insulin by Tryptic Transpeptidations of Porcine Insulin and Biosynthetic Precursors

1987 • 28 citations

The kinetics of hydrolysis of the amide group in proteins and peptides. Part 1. The acid hydrolysis of L-asparagine and L-asparaginylglycine

1953 • 26 citations

Insulin Preparations with Prolonged Effect

1975 • 25 citations

Prolonged Disappearance Rate of a Structurally Abnormal Mutant Insulin from the Circulation in Humans*

1985 • 9 citations

Total insulin levels in type 1 diabetic patients with insulin antibodies and their effect on insulin requirement and metabolic control.

1988 • 9 citations

Insulin

1983 • 6 citations

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