Conversion and Inactivation of Neuropeptides

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Protides of the Biological Fluids

1969 • 1,623 citations

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Handbook of Neurochemistry

1969 • 940 citations

Mechanisms regulating renin release

1976 • 886 citations

INSULIN-I131 METABOLISM IN HUMAN SUBJECTS: DEMONSTRATION OF INSULIN BINDING GLOBULIN IN THE CIRCULATION OF INSULIN TREATED SUBJECTS 1

1956 • 835 citations

New peptide in the vertebrate CNS reacting with antigastrin antibodies

1975 • 749 citations

Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

1976 • 639 citations

The Regional Distribution of Somatostatin in the Rat Brain

1975 • 594 citations

Angiotensin I converting enzyme.

1975 • 566 citations

Induction of Mating Behavior in Rats by Luteinizing Hormone-Releasing Factor

1973 • 533 citations

Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

1976 • 516 citations

C fragment of lipotropin has a high affinity for brain opiate receptors

1976 • 488 citations

Vasoactive Intestinal Polypeptide: Abundant Immunoreactivity in Neural Cell Lines and Normal Nervous Tissue

1976 • 471 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

Handbook of Experimental Pharmacology, vol 14.

1972 • 446 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

Subfornical Organ: Site of Drinking Elicitation by Angiotensin II

1973 • 421 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Concentrations of angiotensin-converting enzyme in tissues of the rat

1971 • 415 citations

Effects of angiotensin on the central nervous system.

1973 • 401 citations

Receptor-binding region of insulin

1976 • 389 citations

The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure-activity studies

1975 • 376 citations

ANGIOTENSIN AND RENIN IN RAT AND DOG BRAIN

1971 • 352 citations

Angiotensin-Forming Enzyme in Brain Tissue

1971 • 315 citations

Renin in dog brain

1971 • 301 citations

DISTRIBUTION AND PROPERTIES OF ANGIOTENSIN CONVERTING ENZYME OF RAT BRAIN

1972 • 298 citations

γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids

1974 • 269 citations

Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals

1975 • 266 citations

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

1976 • 264 citations

Angiotensin II binding to mammalian brain membranes.

1976 • 260 citations

Methods in investigative and diagnostic endocrinology

1975 • 242 citations

ISOLATION OF TWO " BIG GASTRINS " FROM ZOLLINGER-ELLISON TUMOUR TISSUE

1972 • 213 citations

beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

1976 • 206 citations

Behaviourably active ACTH analogues

1975 • 199 citations

Psychoneuroendocrinology

2017 • 199 citations

Methods in investigative and diagnostic endocrinology

1975 • 193 citations

ACTH-like peptides and opiate receptors in the rat brain: Structure-activity studies

1975 • 187 citations

Substance P and Spinal Neurones

1975 • 183 citations

Demonstration of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts.

1976 • 167 citations

Lipotropin: Precursor to two biologically active peptides

1976 • 160 citations

Human foetal pituitary peptides and parturition

1976 • 152 citations

D-Trp8-somatostatin: An analog of somatostatin more potent than the native molecule

1975 • 148 citations

Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6

1976 • 142 citations

Subcellular Mechanisms in Reproductive Neuroendocrinology

1977 • 131 citations

Separation of acid and neutral proteinases of brain

1965 • 128 citations

Protides of the Biological Fluids

1960 • 123 citations

Hypothalamic substance P as a candidate for transmitter of primary afferent neurons.

1975 • 121 citations

Preparation, assay, and partial characterization of a neutral endopeptidase from rabbit brain

1973 • 119 citations

Isolation of brain endopeptidases: influence of size and sequence of substrates structurally related to bradykinin

1976 • 118 citations

Enzymic degradation of luteinizing hormone-releasing hormone (LH-RH) by hypothalamic tissue

1974 • 116 citations

Biological activity of carbon-terminal partial sequences of substance P

1976 • 115 citations

Biosynthesis and Release of Neurophysin

1968 • 113 citations

The Half-life, Metabolism and Excretion of Tritiated Luteinizing Hormone-Releasing Hormone (LH-RH) in Man

1973 • 110 citations

Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies

1972 • 107 citations

Renin Activity in Dog Brain: Enzymological Similarity to Cathepsin D

1976 • 106 citations

A commentary on muscle mechanics.

1975 • 104 citations

Angiotensin‐converting enzyme in human brain

1975 • 103 citations

Purification and Characterization of a Protease with Specificity for Insulin from Rat Muscle

1971 • 97 citations

Evidence for Glucagon Biosynthesis Involving a Protein Intermediate in Islets of the Anglerfish (Lophius americanus)1

1971 • 94 citations

Pyrrolidonyl Peptidase in Animal, Plant and Human Tissues. Occurrence and Some Properties of the Enzyme

1970 • 93 citations

STUDIES ON THE MECHANISM OF CAPTURE AND DEGRADATION OF INSULIN‐I¹³¹ BY THE CYCLICALLY PERFUSED RAT LIVER

1959 • 89 citations

Enzymatic inactivation of substance p by a partially purified enzyme from rat brain

1975 • 87 citations

Enzymatic mechanisms for the inactivation of luteinizing hormone-releasing hormone (LH-RH)

1974 • 86 citations

The kinins

1976 • 84 citations

Biosynthesis of Human Growth Hormone and Prolactin

1970 • 83 citations

Correlation between structure, behavioral activity and rate of biotransformation of some ACTH4-9 analogs.

1975 • 81 citations

Behavioral and Electrographic Changes in Rat and Man after MSH

1975 • 79 citations

Differences in the degradation of hypothalamic releasing factors by rat and human serum

1976 • 79 citations

The Effects of Intracerebroventricular Administration of Renin on Drinking and Blood Pressure¹

1975 • 79 citations

In vivo fate of a behaviorally active ACTH 4-9 analog in rats after systemic administration

1976 • 78 citations

Partial purification and characterization of post-proline cleaving enzyme:

1976 • 78 citations

On the Half Life of Thyrotropin-Releasing Hormone in Rats

1972 • 75 citations

Metabolism of Insulin and Glucagon

1973 • 75 citations

Thyrotropin-Releasing Hormone in the Hypothalamus of the Rat

1974 • 71 citations

Inactivation of somatostatin (GH‐RIH) and its analogs by crude and partially purified rat brain extracts

1975 • 70 citations

Formation of Bradykinin from Kallidin-10 by Aminopeptidase B

1966 • 68 citations

Purification and characterization of the protein component of tissue factor

1970 • 68 citations

Regulation of degradation of thyrotropin releasing hormone by thyroid hormones

1976 • 67 citations

The role of angiotensin in thirst

1975 • 66 citations

LH-releasing activity of potent LH-RH analogs in vitro

1975 • 66 citations

Opioid agonist activity of β‐lipotropin fragments: A possible biological source of morphine‐like substances in the pituitary

1976 • 65 citations

Site of inactivation of thyrotropin-releasing hormone by human plasma

1971 • 64 citations

Some analogs of luteinizing hormone releasing hormone (LH-RH) having intense ovulation-inducing activity

1974 • 61 citations

[Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].

1976 • 61 citations

Insulin receptors, cell membranes and hormone action

1974 • 60 citations

Metabolism of Insulin and Glucagon. Breakdown of Radioiodinated Insulin and Glucagon in Rat Liver Cell Fractions

1971 • 60 citations

BRAIN PEPTIDASES: CONVERSION AND INACTIVATION OF KININ HORMONES

1972 • 59 citations

Bovine Pituitary Pyrrolidonecarboxylyl Peptidase*

1973 • 59 citations

Attempts Toward Biosynthesis of the Thyrotropin-Releasing Hormone and Studies on Its Breakdown in Hypothalamic Tissue Preparations

1976 • 59 citations

Angiotensin-forming enzyme in human brain

1975 • 58 citations

THE PRESENCE OF BRADYKININ-LIKE POLYPEPTIDES, KININ-RELEASING AND DESTROYING ACTIVITY IN BRAIN

1968 • 57 citations

Formation of angiotensin III by angiotensin-converting enzyme

1976 • 57 citations

The inactivation of insulin by tissue extracts; the effect of fasting on the insulinase content of rat liver.

1949 • 57 citations

Production of MSH-release-inhibiting hormone by a particulate preparation of hypothalami: Mechanisms of oxytocin inactivation

1973 • 56 citations

Kinin-converting aminopeptidase from human serum

1973 • 56 citations

Sequential Degradation of Insulin by Rat Liver Homogenates

1972 • 56 citations

The effects of gonadectomy and gonadal steroids on the activity of hypothalamic peptidases inactivating luteinizing hormone-releasing hormone (LH-RH)

1975 • 53 citations

FRONTIERS IN NEUROENDOCRINOLOGY

1973 • 52 citations

Subcellular mechanisms in reproductive neuroendocrinology

1976 • 51 citations

Binding of the protein component of tissue factor to phospholipids

1970 • 50 citations

Correlation between biological potency and biodegradation of a somatostatin analogue

1976 • 50 citations

Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity.

1976 • 50 citations

Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P

1973 • 49 citations

Proteolytic degradation of insulin and glucagon

1975 • 48 citations

Isolation and Biological Characterization of Fragments of Human Growth Hormone Produced by Digestion with Plasmin

1975 • 48 citations

Pentapeptide (Pepstatin) Inhibition of Brain Acid Proteinase

1973 • 47 citations

Studies of enzymatic degradation of luteinizing hormone‐releasing hormone by different tissues

1975 • 45 citations

Blockade of Ovulation in Rats by Inhibitory Analogs of Luteinizing Hormone-Releasing Hormone

1976 • 45 citations

Inhibition of Induced Aldosterone Biosynthesis with a Specific Antagonist of Angiotensin II

1974 • 44 citations

Insulin Degradation: VI. Feedback Control by Insulin of Liver Glutathione-Insulin Transhydrogenase in Rat

1974 • 44 citations

Protein and Polypeptide Breakdown

1971 • 44 citations

Peptide hydrolases in spinal cord and brain of the rabbit

1972 • 44 citations

Enhancement of the growth promoting activity of human growth hormone

1975 • 43 citations

Studies on kinin-like substances in brain

1973 • 43 citations

Thyrotropin Releasing Hormone: Development of Inactivation System During Maturation of the Rat

1976 • 42 citations

Insulin Degradation by Isolated Fat Cells and their Subcellular Fractions

1975 • 42 citations

Polypeptide Hormones: Molecular and Cellular Aspects.

1977 • 41 citations

THE PRESENCE OF PEPTIDASES IN THE RAT HYPOTHALAMUS INACTIVATING LUTEINIZING HORMONE RELEASING HORMONE (LH-RH)

1974 • 41 citations

Growth Hormone: Independent Release of Big and Small Forms from Rat Pituitary in Vitro

1975 • 40 citations

Thromboplastin and plasminogen activator in tissues of the rabbit

1970 • 40 citations

Kallikreins in Glandular Tissues

1970 • 39 citations

Isolation and identification of a pepsitensin

1965 • 37 citations

Degradation of Neurohypophyseal Hormones by Brain Extracts and Purified Brain Enzymes

1973 • 36 citations

The Influence of Enzymes on Neurohypophysial Hormones and Similar Peptides

1968 • 35 citations

Biosynthesis of Thyrotropin-Releasing Hormone in Organ Cultures of the Guinea Pig Median Eminence¹²

1975 • 35 citations

Size Heterogeneity ofβ-MSH in Ectopic ACTH-Producing Tumors: Presence ofβ-LPH-Like Peptide

1976 • 35 citations

Biodegradation of α-MSH and derived peptides by rat brain extracts, and by rat and human serum

1976 • 34 citations

Specific cleavage of a single peptide bond (residues 77–78) in β‐lipotropin by a pituitary endopeptidase

1976 • 33 citations

ACTH Antagonists

1974 • 32 citations

Interactions of adrenocorticotropic hormone with its adrenal receptors. Degradation of ACTH-1-24 and ACTH-11-24.

1975 • 32 citations

Breakdown of bradykinin and its analogs by rat brain neutral proteinase

1971 • 31 citations

A Modulatory Effect of Pituitary Polypeptides on Peripheral Nerve and Muscle

1975 • 31 citations

Role of the disulfide bridge and the C-terminal tripeptide in the antidiuretic action of vasopressin in man and the rat

1975 • 30 citations

Pharmacological significances of peptidase and proteinase in the brain—II

1970 • 29 citations

CHARACTERIZATION OF A RAT BRAIN CATHEPTIC CARBOXYPEPTIDASE (CATHEPSIN A) INACTIVATING ANGIOTENSIN‐II

1976 • 29 citations

ON A KININ-LIKE SUBSTANCE IN THE NERVOUS TISSUE EXTRACTS TREATED WITH TRYPSIN

1961 • 28 citations

Interaction of Parathyroid Hormone with Membranes of Kidney Cortex: Degradation of the Hormone and Activation of Adenylate Cyclase¹

1975 • 27 citations

Insulin degradation by lysosomal extracts from rat liver; model for a role of lysosomes in hormone degradation

1976 • 27 citations

Characteristics of the plasma TRH-degrading enzyme.

1975 • 27 citations

Nitroreduction of carcinogenic 5-nitrothiophenes by rat tissues

1975 • 27 citations

The peptide hormones: molecular and cellular aspects

1975 • 26 citations

SHORT-LOOP FEEDBACK MECHANISM OF LUTEINIZING HORMONE: LH STIMULATES HYPOTHALAMIC L-CYSTINE ARYLAMIDASE TO INACTIVATE LH-RH IN THE RAT HYPOTHALAMUS

1975 • 26 citations

Inactivation studies of angiotensin II by purified enzymes

1971 • 26 citations

Molecular Basis of Insulin Action: Contributions of Chemical Modifications and Synthetic Approaches

1972 • 26 citations

Angiotensinase activity in rat and dog brain

1972 • 25 citations

INACTIVATION OF LUTEINIZING HORMONE RELEASING HORMONE BY RAT HYPOTHALAMIC L-CYSTINE ARYLAMIDASE

1975 • 25 citations

Peptidase activity associated with the tissue factor of blood coagulation

1971 • 25 citations

PEPTIDASES IN THE RAT HYPOTHALAMUS INACTIVATING THYROTROPHIN-RELEASING HORMONE (TRH)

1975 • 25 citations

RELEASE OF CORTICOTROPHIN RELEASING FACTOR AND OTHER HYPOPHYSIOTROPIC SUBSTANCES FROM ISOLATED NERVE-ENDINGS (SYNAPTOSOMES)

1975 • 24 citations

Proteolytic Enzymes as Kininogenases

1970 • 24 citations

Acid Angiotensinase, Renin, and Acid Adenosine Triphosphatase in Rat Kidney Lysosomes

1968 • 23 citations

The purification and biological properties of pancreatic big glucagon

1976 • 22 citations

[28] Methods for the assessment of peptide precursors. Studies on insulin biosynthesis

1975 • 21 citations

Present trends of kinin research

1974 • 21 citations

PROTEIN AND PEPTIDE HYDROLASES OF THE RAT HYPOTHALAMUS AND PITUITARY

1974 • 21 citations

Subcellular Localization of LH Releasing Activity in the Rat Hypothalamus *

1975 • 21 citations

ON THE SEQUENTIAL CLEAVAGE OF MYELIN BASIC PROTEIN BY CATHEPSINS A AND D

1976 • 21 citations

MSH-Release-Inhibiting Factor: Inactivation by Proteolytic Enzymes

1972 • 21 citations

Demonstration of insulin degradation by thiol-protein disulfide oxidoreductase (glutathione-insulin transhydrogenase) and proteinases of pancreatic islets

1976 • 21 citations

Analogues of luteinizing hormone releasing factor modified at positions 2, 6, and 10

1976 • 20 citations

The Effect of Insulin on Fat Cells: An Insulin Degrading System Extracted from Plasma Membranes of Insulin Responsive Cells

1972 • 19 citations

Inactivation of Melanocyte-stimulating Hormone Release-inhibiting Factor by a Manganese-stimulated Bovine Brain Aminopeptidase

1973 • 19 citations

Sites of cleavage of glucagon by insulin-glucagon protease

1975 • 19 citations

The Renin and Iso-Renin-Angiotensin Systems in Rats with Experimental Pituitary Tumors

1975 • 19 citations

Biologically Active Peptides (Substance P)

1970 • 18 citations

Peptidases in different areas of the rat brain inactivating luteinizing hormone-releasing hormone (LH-RH)

1975 • 18 citations

Acid Angiotensinase as a Lysosomal Enzyme

1969 • 18 citations

Metabolism of thyrotropin releasing factor in two clonal cell lines of nervous system origin

1976 • 17 citations

EVIDENCE FOR AN ENZYMIC COMPONENT IN THE RAT HYPOTHALAMUS CAPABLE OF INACTIVATING LUTEINIZING HORMONE RELEASING FACTOR (LRF)

1973 • 17 citations

[29] Technique for the identification of a biosynthetic precursor to parathyroid hormone

1975 • 17 citations

Molecular events taking place during intracellular transport of exportable proteins. The conversion of peptide hormone precursors.

1974 • 17 citations

PEPTIDASE ACTIVITY IN DIFFERENT AREAS OF THE RAT HYPOTHALAMUS

1974 • 16 citations

A paradoxical castration effect on LH-RH levels in male rat hypothalamus and serum

1974 • 15 citations

Separation of cells involved in phytohaemagglutinin-induced mitogenesis and cytotoxicity

1975 • 14 citations

Inactivation of thyrotrophin releasing hormone (TRH) by peptidase in different areas of the rabbit brain

1976 • 13 citations

Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions

1976 • 13 citations

Angiotensin I [Phe8-His9] hydrolase and bradykininase from human lung

1975 • 13 citations

A RADIOIMMUNOASSAY FOR THE MEASUREMENT OF PYROGLUTAMYL-HISTIDYL-PROLINE, A PROPOSED THYROTROPIN RELEASING HORMONE METABOLITE.

1975 • 13 citations

The in vivo fate of brain oligopeptides

1975 • 13 citations

Hormonal control of spermatogenesis

1975 • 13 citations

Dynamics of Protein Metabolism in the Nervous System

1969 • 12 citations

Plasma Oxytocinase: The Synthesis and Biological Properties of the First Prodoct of the Degradation of Oxytocin by this Enzyme

1974 • 12 citations

Immunological Half-Life of Porcine Proinsulin C-Peptide

1975 • 11 citations

Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence

1975 • 11 citations

PHARMACOLOGICAL SIGNIFICANCES OF PEPTIDASE AND PROTEINASE IN THE BRAIN

1970 • 11 citations

BLOCKADE OF OVULATION IN RATS BY INHIBITORY ANALOGS OF LUTEINIZING HORMONE-RELEASING HORMONE

1976 • 10 citations

Synthetic position 5 analogs of adrenocorticotropin fragments and their in vitro lipolytic activity

1975 • 10 citations

Metabolism of two adrenocorticotrophin analogues in the intestine of the rat

1974 • 10 citations

The role of 'insulinase' in the degradation of insulin.

1973 • 9 citations

Structure-Activity Relationships of Synthetic Adrenocorticotropic Octadecapeptides with Special Reference to Biological Half-Life

1971 • 8 citations

Variability of the duration of inhibition of growth hormone release by Nα-acylated-des-[Ala1-Gly2]-H2somatostatin analogs

1975 • 8 citations

Biosynthesis of polypeptide hormones

1976 • 6 citations

Novel Enzymes Involved in the Inactivation of Hypothalamo-Hypophyseal Hormones

2015 • 6 citations

Enzymes that Inactivate Vasoactive Peptides

1971 • 5 citations

An Insulin Degrading Proteinase from Human Erythrocytes and Its Inhibition by Proteinase Inhibitors

1974 • 5 citations

[13] Techniques for the study of polypeptide hormone inactivation at receptor sites

1975 • 4 citations

[Radioimmunologic proinsulin determination in the serum using an "insulin-catabolizing protease" from the rat liver].

1975 • 4 citations

Differential Hydrolysis of Bovine Parathyroid Hormone and its N-terminal Peptide by Rat Kidney

1975 • 3 citations

Degradation of Insulin

1975 • 3 citations

The Hydrolysis of Biologically Active Peptides by Bovine Lung Tissue Factor (Thromboplastin)

1976 • 3 citations

[14] Proteolytic modification of the insulin receptor of adipose tissue cells

1975 • 1 citations

[New hormones of the hypothalamo-neurohypophyseal system].

1973 • 1 citations

The influence of pH in the medium on degradation of neurohormones by pregnancy serum.

1975 • 1 citations