Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset or exacerbation of rheumatoid arthritis.

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Interleukin-1

1984 • 1,625 citations

RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION

1981 • 670 citations

The functional relationship of the interleukins.

1980 • 660 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Isolation of an interleukin‐1‐like factor from human joint effusions

1983 • 450 citations

Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis.

1975 • 393 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

Epidermal Cell Production of Thymocyte Activating Factor (ETAF)

1982 • 319 citations

Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis

1982 • 304 citations

Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.

1984 • 186 citations

The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production

1982 • 179 citations

Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood.

1985 • 172 citations

Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome.

1984 • 152 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

Theophylline modulation of E-rosette formation: an indicator of T-cell maturation.

1978 • 125 citations

In vitro activation of human chondrocytes and synoviocytes by a human interleukin‐1‐like factor

1984 • 125 citations

Polyclonal activation of human lymphocytes in vitro. I. Characterization of the lymphocyte response to a T cell-independent B cell mitogen.

1980 • 123 citations

HLA-DR antigens render resting T cells sensitive to Interleukin-2 and induce production of the growth factor in the autologous mixed lymphocyte reaction

1981 • 85 citations

Staphylococcal protein A, a T cell-regulated polyclonal activator of human B cells.

1980 • 72 citations

Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and skynovial membrane cells from patients with rheumatoid arthritis.

1980 • 66 citations

Basis for the Probit Analysis of an Interferon Plaque Reduction Assay

1972 • 40 citations

Spontaneous production of Interleukin-1 by human alveolar macrophages

1983 • 37 citations

Further studies on the antipyretic action of polymyxin B in pyrogen-induced fever.

1978 • 28 citations

Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis.

1984 • 27 citations

Interleukin abnormalities in recently active rheumatoid arthritis.

1984 • 27 citations

IL 1 requirement for B cell activation revealed by use of adult serum.

1984 • 27 citations

Protein A and enterotoxin A: two distinct Staphylococcus mitogens for human T lymphocytes.

1984 • 23 citations

Increased Number of IgG Fc Receptors on Monocyte‐Enriched Peripheral Blood Leucocytes from Patients with Rheumatoid Arthritis

1982 • 18 citations

Induction of T cell growth factor synthesis in human peripheral blood lymphocytes by staphylococcal protein A

1981 • 15 citations

Monocyte Metabolic Activation in Patients with Rheumatoid Arthritis

1979 • 14 citations

Improved culture conditions for quantitative evaluation of interleukin 2 production by frozen human lymphocytes

1983 • 6 citations