Maternal Age, Paternal Age, and Human Chromosome Abnormality: Nature, Magnitude, Etiology, and Mechanisms of Effects

Human Genetics. Problems and Approaches.

1980 • 1,010 citations

Chiasma Frequency and Maternal Age in Mammals

1968 • 439 citations

Rates of chromosome abnormalities at different maternal ages.

1981 • 418 citations

Maternal age specific rates for chromosome aberrations and factors influencing them: Report of a collaborative european study on 52 965 amniocenteses

1984 • 394 citations

Courtship-feeding, Egg-size and Breeding Success in Common Terns

1973 • 371 citations

The relative effects of paternal and maternal age in mongolism

1933 • 331 citations

Population Cytogenetics: Studies in Humans

1978 • 279 citations

DOG COLLES

1975 • 194 citations

Down syndrome, paternal age, maternal age and birth order

1978 • 122 citations

Mongolism, Delayed Fertilization and Human Sexual Behaviour

1968 • 120 citations

Paternal age effect in Down's syndrome

1977 • 118 citations

Down's syndrome and related abnormalities in an area of high background radiation in coastal Kerala

1976 • 104 citations

Chiasmata, meiotic univalents, and age in relation to aneuploid imbalance in mice

1976 • 104 citations

Trisomy 13 (D1) syndrome: Studies on parentalage, sex ratio, and survival

1968 • 102 citations

Kalmuc Idiocy: Report of a Case with Autopsy

1876 • 98 citations

Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

1982 • 96 citations

Paternal age and Down's syndrome data from prenatal diagnoses (DFG)

1981 • 89 citations

MONOSOMY X: A CHROMOSOMAL ANOMALY ASSOCIATED WITH YOUNG MATERNAL AGE

1980 • 85 citations

Rates of trisomies 21, 18, 13 and other chromosome abnormalities in about 20 000 prenatal studies compared with estimated rates in live births

1982 • 76 citations

The relationship of maternal age and trisomy among trisomic spontaneous abortions.

1984 • 75 citations

Trisomy 21 Down syndrome

1985 • 75 citations

Reexamination of paternal age effect in Down's syndrome

1978 • 70 citations

MATERNAL RADIATION AND MONGOLISM

1962 • 65 citations

CHROMOSOMAL ANOMALIES OF PREIMPLANTATION MOUSE EMBRYOS IN RELATION TO MATERNAL AGE

1973 • 62 citations

Inherited structural cytogenetic abnormalities detected incidentally in fetuses diagnosed prenatally: frequency, parental-age associations, sex-ratio trends, and comparisons with rates of mutants.

1984 • 57 citations

Down syndrome associated with father's age in Norway.

1981 • 57 citations

Parental age and birth order in the aetiology of some sex chromosome aneuploidies

1978 • 56 citations

Genetic Counseling for the Older Pregnant Woman: New Data and Questions

1978 • 56 citations

The origin of the extra chromosome 21 in Down syndrome

1978 • 55 citations

The Nucleolus, Virus Infection, and Trisomy in Man

1967 • 54 citations

Paternal age and Down's syndrome genotypes diagnosed prenatally: No association in New York State data

1982 • 52 citations

The influence of strain, maternal age, and method of maturation on mouse oocyte aneuploidy

1981 • 50 citations

The origin of inverted tandem duplications, and phenotypic effects of tandem duplication of the X chromosome long arm

1983 • 46 citations

A collaborative study of the aetiology of Turner Syndrome

1980 • 44 citations

Radiation-induced nondisjunction in mouse oocytes

1974 • 44 citations

Maternal Age Dependence of Chromosome Anomalies

1973 • 44 citations

Rates of mutant structural chromosome rearrangements in human fetuses: data from prenatal cytogenetic studies and associations with maternal age and parental mutagen exposure.

1983 • 43 citations

OBSERVATIONS ON THE ÆTIOLOGY OF MONGOLISM

1954 • 41 citations

Similar dose-related chromosome non-disjunction in young and old female mice after X-irradiation

1982 • 41 citations

Nondisjunction in aging female mice

1976 • 39 citations

Advanced grandmaternal age on the mother's side – a risk of giving rise to trisomy 21

1984 • 39 citations

An analysis for paternal-age effect in Ohio's Down syndrome births, 1970-1980.

1983 • 39 citations

Paternal age and Down syndrome.

1979 • 39 citations

Down syndrome rates and relaxed selection at older maternal ages.

1983 • 38 citations

A search for a paternal-age effect upon cases of 47, +21 in which the extra chromosome is of paternal origin.

1984 • 37 citations

Paternal age and Down syndrome in British Columbia.

1981 • 34 citations

Radiation-induced nondisjunction in oocytes of aged mice

1977 • 33 citations

Differences in maternal age‐specific rates of down syndrome between Jews of European origin and of north African or Asian origin

1979 • 31 citations

A simple function for maternal-age-specific rates of Down syndrome in the 20-to-49-year age range and its biological implications.

1980 • 30 citations

Grandmaternal age at birth of parents of children with trisomy 21

1977 • 30 citations

Chromosomenanomalien durch Überzahl (Trisomien) und Alter der Mutter*

1966 • 29 citations

Maternal age and origin of non-disjunction in trisomy 21.

1980 • 29 citations

Studies of the genetic and immunologic components of the maternal age effect

1978 • 28 citations

A SEARCH FOR EVIDENCE FOR A PATERNAL AGE EFFECT INDEPENDENT OF A MATERNAL AGE EFFECT IN BIRTH CERTIFICATE REPORTS OF DOWN'S SYNDROME IN NEW YORK STATE

1980 • 26 citations

Comparison of mathematical models for the maternal age dependence of Down's syndrome rates

1981 • 24 citations

Parental age and unbalanced Robertsonian translocations associated with Down syndrome and Patau syndrome: comparison with maternal and paternal age effects for 47, + 21 and 47, + 13

1984 • 21 citations

Reexamination of paternal age effect in Down's syndrome

1983 • 20 citations

Human Sexual Behaviour, Delayed Fertilization and Down's Syndrome

1969 • 19 citations

NON-DISJUNCTION AND MATERNAL AGE IN THE MOUSE

1965 • 19 citations

Paternal age in Down's syndrome.

1967 • 19 citations

On the inadequacy of quinquennial data for analyzing the paternal age effect on Down's dyndrome rates

1980 • 18 citations

Down's syndrome in Kerala

1977 • 18 citations

An aetiological study of 290 XXY males, with special reference to the role of paternal age

1984 • 17 citations

Oocyte sensitivity to induced meiotic nondisjunction and its relationship to advanced maternal age

1983 • 10 citations

Down's syndrome in Kerala

1977 • 8 citations

Is routine prenatal karyotyping indicated in pregnancies of very young women?

1973 • 7 citations

Factors distinguishing couples at risk for nondisjunction

1984 • 7 citations

Are There Two Maternal Age Groups in Down's Syndrome?

1974 • 6 citations

Deleted Work

1955 • 0 citations