The Mechanism of Conversion of Xanthine Dehydrogenase to Oxidase and the Role of the Enzyme in Reperfusion Injury

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

The Regulation of Rat Liver Xanthine Oxidase

1969 • 722 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium

1981 • 435 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

Hypoxanthine as an Indicator of Hypoxia: Its Role in Health and Disease through Free Radical Production

1988 • 408 citations

Allopurinol and oxypurinol are hydroxyl radical scavengers

1987 • 393 citations

The pathophysiology of superoxide: roles in inflammation and ischemia

1982 • 368 citations

The Mechanism of Action of Xanthine Oxidase

1974 • 337 citations

Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin.

1990 • 276 citations

Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase

1976 • 209 citations

Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage

1987 • 203 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues

1989 • 116 citations

Xanthine oxidoreductase activity in perfused hearts of various species, including humans.

1990 • 114 citations

Regulation of xanthine oxidase in rat liver: modifications of the enzyme activity of rat liver supernatant on storage at 20 degrees

1968 • 112 citations

Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed-chest dogs with small infarcts

1985 • 97 citations

Differences in redox and kinetic properties between NAD-dependent and O2-dependent types of rat liver xanthine dehydrogenase

1989 • 94 citations

Preparation of Bovine Milk Xanthine Oxidase as a Dehydrogenase Form

1982 • 83 citations

The reactivity of chicken liver xanthine dehydrogenase with molecular oxygen

1989 • 80 citations

The Nicotinamide Adenine Dinucleotide-Binding Site of Chicken Liver Xanthine Dehydrogenase

1989 • 67 citations

Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium

1991 • 60 citations

The presence of desulfo xanthine dehydrogenase in purified and crude enzyme preparations from rat liver

1986 • 56 citations

Differences in Protein Structure of Xanthine Dehydrogenase and Xanthine Oxidase Revealed by Reconstitution with Flavin Active Site Probes

1989 • 51 citations

The regulation of xanthine oxidase. Inhibition by reduced nicotinamide–adenine dinucleotide of rat liver xanthine oxidase type D and of chick liver xanthine dehydrogenase

1970 • 45 citations

Differences in Environment of FAD between NAD-dependent and O2-dependent Types of Rat Liver Xanthine Dehydrogenase Shown by Active Site Probe Study

1989 • 41 citations

Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effect

1981 • 30 citations

Evidence for the existence of a tyrosyl residue in the nicotinamide adenine dinucleotide binding site of chicken liver xanthine dehydrogenase

1987 • 22 citations

Regulation of Purine Nucleotide Metabolism in Hypoxic Liver and Intestine of Rats: Radical Scavenging Effects of Allopurinol and Oxypurinol

1989 • 7 citations