Granule-Mediated Cytolysis of Target Cells

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors.

1984 • 337 citations

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.

1984 • 329 citations

Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes.

1985 • 300 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

The Ninth Component of Complement and the Pore-Forming Protein (Perforin 1) from Cytotoxic T Cells: Structural, Immunological, and Functional Similarities

1986 • 272 citations

Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells

1983 • 253 citations

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes.

1983 • 229 citations

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells

1987 • 201 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

The molecular mechanism of lymphocyte-mediated tumor cell lysis

1985 • 183 citations

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

1987 • 174 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Specific release of proteoglycans from human natural killer cells during target lysis

1985 • 146 citations

Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9.

1985 • 139 citations

Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

1980 • 119 citations

Identification, isolation, and characterization of a novel cytotoxin in murine cytolytic lymphocytes

1987 • 113 citations

Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes.

1987 • 109 citations

The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells.

1985 • 106 citations

Differences in target cell DNA fragmentation induced by mouse cytotoxic T lymphocytes and natural killer cells.

1986 • 102 citations

High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.

1987 • 72 citations

The role of Ca2+ in activation of mature cytotoxic T lymphocytes for lysis.

1987 • 49 citations

The degree of CTL-induced DNA solubilization is not determined by the human vs mouse origin of the target cell.

1987 • 39 citations

Are lytic granules and perforin 1 involved in lysis induced by in vivo-primed peritoneal exudate cytolytic T lymphocytes?

1987 • 37 citations

DNA Degradation in Mammalian Cells Following Complement-Mediated Cytolysis

1971 • 18 citations

Granule exocytosis by cytotoxic T lymphocytes generated in vivo

1987 • 11 citations

Deleted Work

1955 • 0 citations