Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis.

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

Aggregation of Mutant Cu/Zn Superoxide Dismutase Proteins in a Culture Model of ALS

1997 • 355 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors

1997 • 223 citations

Intramuscular Grafts of Myoblasts Genetically Modified to Secrete Glial Cell Line-Derived Neurotrophic Factor Prevent Motoneuron Loss and Disease Progression in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

1999 • 146 citations

GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice

1996 • 141 citations

Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene

1999 • 123 citations

Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice

2001 • 108 citations

Adenovirus-Mediated Gene Transfer of Glial Cell Line-Derived Neurotrophic Factor Prevents Ischemic Brain Injury after Transient Middle Cerebral Artery Occlusion in Rats

1999 • 95 citations

Stimulation of erythropoiesis by in vivo gene therapy: physiologic consequences of transfer of the human erythropoietin gene to experimental animals using an adenovirus vector

1994 • 70 citations

Effects of GDNF on Axotomized Sensory and Motor Neurons in Adult Rats

1997 • 67 citations

Adenoviral cardiotrophin-1 gene transfer protects pmn mice from progressive motor neuronopathy

1999 • 64 citations

In vivo adenovirus-mediated gene transfer and the expression in ischemic and reperfused rat brain

1997 • 43 citations

Early decrease of survival signal-related proteins in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene.

2001 • 43 citations

Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease

1997 • 38 citations

Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene

2001 • 19 citations

Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite

2001 • 18 citations

Expression of adenovirus-mediated E. coli lacZ gene in skeletal muscles and spinal motor neurons of transgenic mice with a mutant superoxide dismutase gene

1998 • 12 citations

Expressions of caspase-3, Tunel, and Hsp72 immunoreactivities in cultured spinal cord neurons of rat after exposure to glutamate, nitric oxide, or peroxynitrite

2001 • 6 citations

Glutamate enhances DNA fragmentation in cultured spinal motor neurons of rat

2001 • 5 citations