Somatomedins (Insulin-Like Growth Factors) and the Nervous System

Growth Factors and Cancer

1991 • 2,044 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

Somatomedin-C Mediates Growth Hormone Negative Feedback by Effects on Both the Hypothalamus and the Pituitary

1981 • 829 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

1986 • 531 citations

An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

1978 • 472 citations

Receptor-Mediated Transport of Insulin Across Endothelial Cells

1985 • 462 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.

1985 • 436 citations

Evidence that somatomedin is synthesized by multiple tissues in the fetus

1980 • 434 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Monoclonal antibodies to receptors for insulin and somatomedin-C.

1983 • 423 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

1963 • 399 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Hormone families: pancreatic hormones and homologous growth factors

1980 • 375 citations

Induction of Immunoreactive Somatomedin C in Human Serum by Growth Hormone: Dose-Response Relationships and Effect on Chromatographic Profiles*

1980 • 356 citations

Insulin-Like Growth Factors: A Role in Growth Hormone Negative Feedback and Body Weight Regulation via Brain

1983 • 354 citations

Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication-stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor

1980 • 346 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II

1984 • 326 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

1986 • 322 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

SEQUENCE ANALYSIS OF SOMATOMEDIN-C: CONFIRMATION OF IDENTITY WITH INSULIN-LIKE GROWTH FACTOR I

1983 • 297 citations

Insulin-like growth factor: a model for tertiary structure accounting for immunoreactivity and receptor binding.

1978 • 282 citations

The Somatomedins: A Family of Insulinlike Hormones under Growth Hormone Control

1974 • 281 citations

1 Biological and immunological properties of insulin-like growth factors (IGF) I and II

1984 • 279 citations

Human Growth Hormone and Somatomedin C Suppress the Spontaneous Release of Growth Hormone in Unanesthetized Rats*

1983 • 277 citations

Insulin-Like Growth Factor I Action on Rat Anterior Pituitary Cells: Suppression of Growth Hormone Secretion and Messenger Ribonucleic Acid Levels*

1986 • 265 citations

Insulin-like growth factors and insulin: comparative aspects

1985 • 262 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I

1983 • 254 citations

Somatomedins

1980 • 247 citations

Insulin-Like Growth Factors/Somatomedins: Structure, Secretion, Biological Actions and Physiological Role

1986 • 240 citations

The Somatomedins: Insulin-Like Growth Factors

1986 • 231 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nerves

1986 • 223 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

1985 • 203 citations

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

1984 • 199 citations

Ontogenesis of somatomedin and insulin receptors in the human fetus.

1983 • 197 citations

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells

1984 • 194 citations

Effect of Diabetes and its Control on Insulin-like Growth Factors in the Young Subject with Type I Diabetes

1984 • 189 citations

Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling

1981 • 187 citations

Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats

1985 • 180 citations

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

1985 • 174 citations

Purification and Characterization of Multiplication‐Stimulating Activity

1980 • 171 citations

Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane.

1984 • 169 citations

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells.

1984 • 168 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

1982 • 166 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

1985 • 164 citations

Two types of receptor for insulin-like growth factors in mammalian brain.

1985 • 163 citations

Release of Somatomedin-Like Activity by Cultured WI-38 Human Fibroblasts*

1980 • 162 citations

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

1976 • 161 citations

THE SERUM HALF-LIFE OF SOMATOMEDIN ACTIVITY: EVIDENCE FOR GROWTH HORMONE DEPENDENCE

1976 • 159 citations

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

1982 • 158 citations

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA

1985 • 155 citations

Characterization of the Somatomedin-C/Insulin-Like Growth Factor I (SM-C/IGF-I) Receptor on Cultured Human Fibroblast Monolayers: Regulation of Receptor Concentrations by SM-C/IGF-I and Insulin*

1982 • 154 citations

Insulin-Infusion-Pump Treatment of Diabetes

1981 • 153 citations

Specific binding of a somatomedin-like polypeptide in rat serum depends on growth hormone

1976 • 146 citations

Multiple Hormones Stimulate the Production of Somatomedin by Cultured Human Fibroblasts*

1984 • 143 citations

Immunoreactive Somatomedin-C/Insulin-Like Growth Factor I and Its Binding Protein in Human Milk*

1984 • 141 citations

3 Paracrine functions of somatomedins

1986 • 140 citations

Further Characterization of Growth Hormone-Dependent Somatomedin-Binding Proteins in Rat Serum and Demonstration of Somatomedin-Binding Proteins Produced by Rat Liver Cells in Culture*

1979 • 138 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Production of “Sulphation Factor” by the Perfused Liver

1970 • 129 citations

Characterization of High Affinity Receptors for Insulin-Like Growth Factors I and II on Rat Anterior Pituitary Cells*

1984 • 128 citations

Isolation of a Somatomedin-Binding Protein from Preterm Amniotic Fluid. Development of a Radioimmunoassay*

1984 • 127 citations

Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.

1984 • 126 citations

Somatomedins

1980 • 126 citations

FURTHER IMMUNOLOGICAL STUDIES ON THE FORM OF CIRCULATING INSULIN

1962 • 123 citations

Plasma Somatomedin-Binding Proteins in Hypopituitarism: Changes during Growth Hormone Therapy*

1981 • 123 citations

Nutrition and Somatomedin

1987 • 120 citations

Prolactin-stimulated production of somatomedin by rat liver

1975 • 120 citations

Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.

1985 • 119 citations

Production of Insulin-Like Growth Factor I and Its Binding Protein by Adult Rat Hepatocytes in Primary Culture*

1985 • 115 citations

Insulin-Like Growth Factor I Regulates Growth Hormone Secretion and Messenger Ribonucleic Acid Levels in Human Pituitary Tumor Cells∗

1986 • 113 citations

Affinity-labeled plasma somatomedin-C/insulinlike growth factor I binding proteins. Evidence of growth hormone dependence and subunit structure.

1985 • 113 citations

Effect of in Vitro Action of Serum Proteases or Exposure to Acid on Measurable Immunoreactive Somatomedin-C in Serum*

1983 • 112 citations

Somatomedin-C and platelet-derived growth factor stimulate human fibroblast replication

1981 • 111 citations

2 Plasma forms of somatomedin and the binding protein phenomenon

1984 • 108 citations

Effects of Insulin-Like Growth Factors on Adult Male Rat Pituitary Function in Tissue Culture*

1984 • 106 citations

Amino acid sequence of a variant pro-form of insulin-like growth factor II.

1985 • 106 citations

Liberation of Immunoreactive Somatomedin-C from Its Binding Proteins by Proteolytic Enzymes and Heparin*

1983 • 105 citations

The Growth Hormone Dependence of a Somatomedin-Binding Protein in Human Serum*

1981 • 101 citations

Regulation of Growth Hormone Release from Cultured Human Pituitar Adenomas by Somatomedins and Insulin*

1985 • 99 citations

Isolation and characterization of variant IGF‐1 as well as IGF‐2 from adult human brain

1986 • 97 citations

The characterization of somatomedin A, isolated by microcomputer-controlled chromatography, reveals an apparent identity to insulin-like growth factor 1

1984 • 97 citations

The Somatomedins and Their Actions

1978 • 96 citations

5 Somatomedin levels in childhood, adolescence and adult life

1984 • 92 citations

Rat Hepatocyte Insulin-Like Growth Factor I and Binding Protein: Effect of Growth Hormonein Vitroandin Vivo*

1985 • 91 citations

Characterization of the Receptors for Insulin and the Insulin-Like Growth Factors on Micro- and Macrovascular Tissues*

1985 • 90 citations

Insulin-like growth factor-I (IGF-I) stimulates tyrosine kinase activity in purified receptors from a rat liver cell line

1984 • 89 citations

Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

1982 • 89 citations

The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand.

1986 • 87 citations

Characterization of Somatomedin Binding in Human Serum by Ultracentrifugation and Gel Filtration*

1982 • 86 citations

Current Concepts of Somatomedin and Other Biologically Related Growth Factors

1976 • 85 citations

Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

1983 • 85 citations

Somatomedin (Insulin-Like Growth Factors)-Binding Proteins

1986 • 84 citations

Somatomedin C: Restoration in Vivo of Cycle Traverse in G ₀ /G ₁ Blocked Cells of Hypophysectomized Animals

1980 • 83 citations

Cerebral gigantism (Sotos syndrome). Compiled data of 22 cases

1985 • 83 citations

Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells.

1985 • 81 citations

Growth and Somatomedins

1983 • 81 citations

Human embryonic somatomedin.

1981 • 81 citations

Dependence of food intake on acute and chronic ventricular administration of insulin

1986 • 80 citations

Preferential Measurement of Insulin-Like Growth Factor (IGF) I-Related Peptides in Serum with the Aid of IGF-Binding Proteins (IGF BPs) Produced by Rat Liver in Culture. Estimation of Serum IGF BP Levels*

1984 • 78 citations

Insulin and Insulin-Like Growth Factor (Somatomedin) Receptors on Cloned Rat Pituitary Tumor Cells*

1985 • 78 citations

Purification of an insulin-like growth factor II receptor from rat chondrosarcoma cells.

1983 • 78 citations

Mitogenic response of human SH-SY5Y neuroblastoma cells to insulin-like growth factor I and II is dependent on the stage of differentiation.

1986 • 78 citations

Purification and characterization of the receptor for insulin-like growth factor I

1986 • 77 citations

EVIDENCE FOR PRODUCTION BY THE LIVER OF TWO IGF BINDING PROTEINS WITH SIMILAR MOLECULAR WEIGHTS BUT DIFFERENT AFFINITIES FOR IGF I AND IGF II. THEIR RELATIONS WITH SERUM AND CEREBROSPINAL FLUID IGF BINDING PROTEINS.

1982 • 73 citations

Insulin-Like Growth Factor (IGF)&slash;Somatomedin Receptor Subtypes: Structure, Function, and Relationships to Insulin Receptors and IGF Carrier Proteins

1986 • 72 citations

Purification of the type II insulin-like growth factor receptor from rat placenta.

1983 • 71 citations

Identification of Binding Sites for an Insulin-like Growth Factor (IGF-1) in the Median Eminence of the Rat Brain by Quantitative Autoradiography

1986 • 69 citations

Somatomedin production by rat liver in organ culture. III. Studies on the release of insulin-like growth factor and its carrier protein measured by radioligand assays. Effects of growth hormone, insulin and cortisol.

1982 • 68 citations

Somatomedin Inhibitors From Diabetic Rat Serum Alter Growth and Development of Mouse Embryos in Culture

1986 • 67 citations

The insulin-like growth factor II receptor is phosphorylated by a tyrosine kinase in adipocyte plasma membranes.

1986 • 65 citations

Comparison of Somatomedin Activity in Perfusates of Normal and Hypophysectomized Rat Livers With and Without Added Growth Hormone

1976 • 65 citations

Neonatal Rat Islet Cell Cultures Synthesize Insulin-like Growth Factor I

1985 • 65 citations

Circumventricular Organs: Receptors and Mediators of Direct Peptide Hormone Action on Brain

1983 • 64 citations

Affinity-Labeled Somatomedin-C Receptors and Binding Proteins from the Human Fetus*

1984 • 62 citations

IGF-II binding on human lymphoid cells: Demonstration of a common high affinity receptor for insulin like peptides

1984 • 60 citations

Distinct receptors for IGF-I, IGF-II, and insulin are present on bovine capillary endothelial cells and large vessel endothelial cells

1984 • 59 citations

Somatomedin carrier proteins

1984 • 58 citations

Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders

1984 • 58 citations

Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit.

1986 • 57 citations

Isolation and characterization of polypeptides from human plasma enhancing the growth of human normal cells in culture

1974 • 56 citations

Insulin-induced Loss of Insulin-like Growth Factor-I Receptors on IM-9 Lymphocytes

1982 • 56 citations

Effect of diabetes and its control on insulin-like growth factors in the young subject with type I diabetes

1984 • 55 citations

Multiplication stimulating activity (MSA) from the BRL 3A rat liver cell line: Relation to human somatomedins and insulin

1981 • 54 citations

An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors.

1986 • 54 citations

Partial Purification, Characterization, and Assay of a Slightly Acidic Insulin-Like Peptide (ILAs) from Human Plasma*

1978 • 53 citations

Insulin-Like Growth Factor-I Action on Hypothyroid Rat Pituitary Cells: Suppression of Triiodothyronine- Induced Growth Hormone Secretion and Messenger Ribonucleic Acid Levels*

1986 • 53 citations

Human somatomedians. Purification and some studies on their biological actions.

1973 • 52 citations

Identification of human semen insulin-like growth factor-I/somatomedin-C immunoreactivity and binding protein

1984 • 52 citations

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

1986 • 51 citations

Specific Assay for Insulin-Like Growth Factor (IGF) II Using the IGF Binding Proteins Extracted from Human Cerebrospinal Fluid*

1986 • 50 citations

Human somatomedin. Determination, occurrence, biological activity and purification.

1972 • 47 citations

Processing of Insulin-Like Growth Factors I and II by Capillary and Large Vessel Endothelial Cells*

1986 • 46 citations

Growth and somatomedin responses to growth hormone in Down's syndrome.

1986 • 45 citations

Somatomedin B: Mitogenic Activity Derived from Contaminant Epidermal Growth Factor

1981 • 45 citations

Synthesis by cultured hepatocytes of somatomedin and its binding protein

1979 • 42 citations

The distribution of somatomedins in the nervous system of the cat and their release following neural stimulation

1982 • 42 citations

Somatomedins in Down's syndrome.

1983 • 41 citations

The influence of purified somatomedins and insulin on foetal rat brain DNA synthesis in vitro

1985 • 40 citations

Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor

1982 • 39 citations

Processing of cell-bound insulin by capillary and macrovascular endothelial cells in culture

1985 • 39 citations

Somatomedins in aging and dementia disorders of the Alzheimer type

1982 • 39 citations

Processing and Release of Insulin and Insulin-Like Growth Factor I by Macro- and Microvascular Endothelial Cells*

1986 • 39 citations

Insulin-Like Growth Factor Receptors in Rat Placental Membranes*

1984 • 39 citations

Somatomedin production by rat liver in organ culture

1980 • 38 citations

Chemistry, structure, and function of insulin-like growth factors and their receptors: a review

1984 • 37 citations

Effect of thyroid function on serum somatomedin activity

1981 • 37 citations

Current concepts of somatomedin and other biologically related growth factors

1976 • 37 citations

[Somatomedin inhibition of the growth hormone secretion stimulated by the hypothalamic factor somatocrinin or the synthetic peptide hpGRF].

1982 • 36 citations

Somatomedin production by rat liver in organ culture

1982 • 33 citations

Structure of Somatomedin-Binding Protein: Alkaline pH-Induced Dissociation of an Acid-Stable, 60,000 Molecular Weight Complex into Smaller Components

1982 • 32 citations

Interrelationships among receptor structures for insulin and peptide growth factors.

1983 • 32 citations

Somatomedin inhibitors from diabetic rat serum alter growth and development of mouse embryos in culture

1986 • 30 citations

Mitogenic activity of glia maturation factor

1985 • 28 citations

Isolation and Chemistry of Human Somatomedins A and B

1975 • 27 citations

Regulation of the Cell Cycle by Somatomedins

1982 • 27 citations

Somatomedins (insulin-like growth factors), but not growth hormone, are mitogenic for chicken heart mesenchymal cells and act synergistically with epidermal growth factor and brain fibroblast growth factor

1984 • 27 citations

Nutrition and somatomedin. XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes

1985 • 26 citations

Neonatal rat islet cell cultures synthesize insulin-like growth factor I

1985 • 26 citations

Size Discrepancy Between Somatomedin-C and Insulin Receptors*

1984 • 25 citations

Tyrosine kinase activity of brain insulin and IGF-1 receptors

1986 • 25 citations

Stimulation of³⁵S Incorporation into Embryonic Chick Cartilage by Extract from Rat Muscle

1969 • 25 citations

INSULIN‐LIKE GROWTH FACTOR AND ITS CARRIER PROTEIN IN HYPOPITUITARY AND HYPOTHYROID CHILDREN AND ADULTS

1980 • 24 citations

Cerebral Gigantism

1965 • 23 citations

Pulsatility of Immunoreactive Somatomedin-C in Chronically Cannulated Rats*

1983 • 22 citations

Receptors for insulin-like growth factors and insulin on murine fetal cortical brain cells

1986 • 21 citations

Insulin-induced loss of insulin-like growth factor-I receptors on IM-9 lymphocytes

1982 • 19 citations

Reciprocal modulation of insulin and insulin-like growth factor-I receptor affinity by calcium

1983 • 19 citations

9 Somatomedin-C/insulin-like growth factor I in acromegaly

1986 • 18 citations

SOMATOMEDIN ACTIVITY IN CEREBROSPINAL FLUID

1975 • 18 citations

Characterization of the human placental receptor for basic somatomedin

1982 • 18 citations

Increased levels of somatomedins in human lumbar and central cerebrospinal fluid after subarachnoid haemorrhage

1985 • 17 citations

Insulin stimulation of somatomedin A production in monolayer cultures of rat hepatocytes

1983 • 17 citations

Changes in somatomedin activity in anorexia nervosa.

1985 • 15 citations

Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors; Evidence of a role for intracellular calcium

1984 • 15 citations

Intracellular (Golgi) receptors for insulinlike peptides in rat liver

1980 • 15 citations

Insulin-like growth factor II receptors. Molecular radius and molecular weight determination using quantitative polyacrylamide gel electrophoresis.

1984 • 13 citations

Insulin-like growth factor inhibition of growth hormone secretion

1986 • 11 citations

Cerebral gigantism: a report of two cases with elevated serum somatomedin A levels and a review of the Japanese literature.

1977 • 11 citations

Somatomedin Binding Proteins in GH-Deficient Children with Normal Plasma Somatomedin Levels*

1983 • 10 citations

The Presence of Normal Levels of Serum Immunoreactive Insulin-like Growth Factor 2 (IGF-2) in Patients with Down's Syndrome

1984 • 9 citations

Molecular Aspects of the Human Somatomedins

1986 • 8 citations

Brain Growth-Promoting Activity in Human Serum: Relationship to Growth Hormone and Somatomedin

1978 • 8 citations

Properties and concentrations of somatomedin A in various rat tissues.

1979 • 7 citations

Autoradiographic visualization of insulin-like growth factor-II receptors in rat brain

1986 • 4 citations