Immunoglobulin E: Biosynthesis and Immunological Mechanisms of IgE-Mediated Hypersensitivity

STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA

1964 • 663 citations

The Regulatory Influence of Activated T Cells on B Cell Responses to Antigen

1972 • 633 citations

Identification of gamma-E-antibodies as a carrier of reaginic activity.

1967 • 541 citations

Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity.

1966 • 511 citations

Immunological studies of an atypical (myeloma) immunoglobulin.

1967 • 477 citations

Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth gamma-E-globulin antibody.

1966 • 426 citations

Identification of γE-Antibodies as a Carrier of Reaginic Activity

1967 • 399 citations

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

1971 • 338 citations

Physico-Chemical Properties of Human Reaginic Antibody

1966 • 325 citations

THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS

1974 • 307 citations

Asthma; physiology, immunopharmacology and treatment

1986 • 273 citations

The IgE-Mediated Release of an Eosinophil Leukocyte Chemotactic Factor from Human Lung

1971 • 244 citations

Mechanisms of passive sensitization. I. Presence of IgE and IgG molecules on human leukocytes.

1970 • 242 citations

THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS

1974 • 236 citations

STUDIES ON THE MECHANISM OF HYPERSENSITIVITY PHENOMENA

1957 • 226 citations

Identification of Basophil Granulocytes as a Site of Allergic Histamine Release

1972 • 224 citations

Biology of immunoglobulin E. Molecular basis of reaginic hypersensitivity.

1975 • 191 citations

Human reaginic antibodies and immunoglobulin E

1968 • 176 citations

Biologic function of the Fc fragments of E myeloma protein

1970 • 172 citations

Triggering of Histamine Release from Rat Mast Cells by Divalent Antibodies against IgE-Receptors

1978 • 165 citations

The Capacity of Human Immunoglobulin E to Mediate the Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung

1970 • 154 citations

Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH.

1974 • 152 citations

Mechanisms of passive sensitization. 3. Number of IgE molecules and their receptor sites on human basophil granulocytes.

1973 • 150 citations

Physicochemical properties of reaginic antibody. VI. Effect of heat on gamma-E-, gamma-G- and gamma-A-antibodies in the sera of ragweed sensitive patients.

1967 • 148 citations

INHIBITION OF PRAUSNITZ-KUSTNER REACTION BY PROTEOLYTIC-CLEAVAGE FRAGMENTS OF A HUMAN MYELOMA PROTEIN OF IMMUNOGLOBULIN CLASS E

1968 • 142 citations

Specific in vitro histamine release from basophils by bivalent haptens: Evidence for activation by simple bridging of membrane bound antibody

1975 • 134 citations

Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) by IgE-Anti-IgE Reactions on Monkey Mast Cells

1972 • 127 citations

Histamine release from human leukocytes by anti-gamma E antibodies.

1969 • 126 citations

Regulation of antibody response in vitro. VI. Carrier-specific helper cells for IgG and IgE antibody response.

1973 • 124 citations

Allergen-binding activity of gamma-E, gamma-G and gamma-A antibodies in sera from atopic patients. In vitro measurements of reaginic antibody.

1967 • 119 citations

Mechanisms of Passive Sensitization

1970 • 119 citations

Reversed type allergic skin reactions by anti-gamma-E-globulin antibodies in humans and monkeys.

1968 • 117 citations

Binding Parameters of the Interaction Between Rat IgE and Rat Mast Cell Receptors

1975 • 116 citations

ELECTRON MICROSCOPIC LOCALIZATION OF IMMUNOGLOBULIN E ON THE SURFACE MEMBRANE OF HUMAN BASOPHILS

1971 • 113 citations

Studies on the mechanisms of hypersensitivity phenomena. XIV. Passive sensitization in vitro of human leukocytes to ragweed pollen antigen.

1966 • 106 citations

Immune Mechanisms of Reversed Type Reaginic Hypersensitivity

1969 • 101 citations

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE

1973 • 100 citations

Immunogenic properties of modified antigen E. II. Ability of urea-denatured antigen and alpha-polypeptide chain to prime T cells specific for antigen E.

1975 • 92 citations

Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells.

1976 • 91 citations

Histamine Release from Human Leukocytes by Anti-λE Antibodies

1969 • 90 citations

Degranulation of human basophil leukocytes by anti-gamma E antibody.

1971 • 87 citations

Persistent formation of reagins in mice injected with low doses of ovalbuminl.

1971 • 87 citations

Allergen-Binding Activity of γE, γG and γA Antibodies in Sera from Atopic Patients

1967 • 86 citations

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE

1973 • 85 citations

Mechanisms of Passive Sensitization

1973 • 83 citations

Mechanisms of passive sensitization. II. Presence of receptors for IgE on monkey mast cells.

1971 • 82 citations

The rat basophilic leukemia cell receptor for IgE. I. Characterization as a glycoprotein.

1976 • 77 citations

Reaginic antibody formation in the mouse

1981 • 76 citations

In Vivo and in Vitro Production of a Slow Reacting Substance in the Rat Upon Treatment with Calcium Ionophores

1974 • 75 citations

A comparative antigenic study of gamma E-globulin and myeloma-IgND.

1969 • 74 citations

The nature of the antigen-antibody complexes initiating the specific wheal-and-flare reaction in sensitized man

1968 • 74 citations

Reversed Type Allergic Skin Reactions by Anti-γE-Globulin Antibodies in Humans and Monkeys

1968 • 73 citations

Antigenic structure of gamma-E-globulin and reaginic antibody.

1967 • 72 citations

Reaginic antibody formation in the mouse

1975 • 70 citations

Regulation of antibody response in vitro. IV. Heavy chain antigenic determinants on hapten-specific memory cells.

1972 • 68 citations

Histamine Release from Rat Mast Cells by Antibodies against Rat Basophilic Leukemia Cell Membrane

1977 • 67 citations

A Comparative Antigenic Study of λE-Globulin and Myeloma-IgND

1969 • 66 citations

Induction of erythema-wheal reactions by soluble antigen-gammaE antibody complexes in humans.

1968 • 65 citations

Chemical modifications of the major allergen of ragweed pollen, antigen E

1974 • 65 citations

Studies on the Mechanisms of Hypersensitivity Phenomena

1966 • 64 citations

Antigenic Structure of γE-Gobulin and Reaginic Antibody

1967 • 64 citations

Reaginic antibody formation in the mouse. VII. Induction of suppressor T cells for IgE and IgG antibody responses.

1976 • 64 citations

Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells.

1974 • 63 citations

Degranulation of Human Basophil Leukocytes by Anti-γE Antibody

1971 • 63 citations

IgE formation in the rat following infection with Nippostrongylus brasiliensis

1976 • 62 citations

Regulation of Immunoglobulin and Antibody Production Allotype Suppressor T Cells in Mice

1975 • 61 citations

Suppression of Reaginic Antibodies with Modified Allergens

1978 • 61 citations

Immunogenic properties of modified antigen E. I. Presence of specific determinants for T cells in denatured antigen and polypeptide chains.

1974 • 58 citations

Regulation of Antibody Response in Vitro

1973 • 57 citations

Characterization of the Target Cell Receptor for IgE

1976 • 56 citations

Immunogenic properties of modified antigen E. III. Effect of repeated injections of modified antigen on immunocompetent cells specific for native antigen.

1975 • 55 citations

Characterization of the target cell receptor for IgE. III. properties of the receptor isolated from rat basophilic leukemia cells by affinity chromatography.

1978 • 55 citations

Biologic Activities of Aggregated Immunoglobulin E

1970 • 53 citations

Physicochemical Properties of Reaginic Antibody

1967 • 52 citations

Mechanisms of Passive Sensitization

1971 • 51 citations

The Rat Basophilic Leukemia Cell Receptor for IgE

1976 • 50 citations

Sequential expression of germ line genes in development of immunoglobulin class diversity.

1975 • 46 citations

Biologic Significance of Disulfide Bonds in Human IgE Molecules

1975 • 46 citations

Regulation of antibody response in different immunoglobulin classes. II. Induction of in vitro IgE antibody response in murine spleen cells and demonstration of a possible involvement of distinct T-helper cells in IgE and IgG antibody responses.

1977 • 45 citations

Regulation of antibody response in different immunoglobulin classes. III. In vitro demonstration of "IgE class-specific" suppressor functions of DNP-mycobacterium-primed T cells and the soluble factor released from these cells.

1977 • 44 citations

Molecular weight and valence of the cell-surface receptor for immunoglobulin E.

1977 • 44 citations

Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes.

1974 • 43 citations

Mechanisms of Passive Sensitization

1974 • 43 citations

Thymus Dependence of Reaginic Antibody Formation in Mice

1973 • 43 citations

Induction of Erythema-Wheal Reactions by Soluble Antigen-γE Antibody Complexes in Humans

1968 • 42 citations

Induction of passive cutaneous anaphylaxis in monkeys by human γE antibody

1967 • 39 citations

Reaginic antibody formation in the mouse. VII. Depression of the ongoing IgE antibody formation by suppressor T cells.

1976 • 33 citations

Regulation of Antibody Response in Different Immunoglobulin Classes

1976 • 32 citations

Regulation of antibody response in different immunoglobulin classes. I. Selective suppression of anti-DNP IgE antibody response by preadministration of DNP-coupled mycobacterium.

1976 • 31 citations

On the nature of the presumed receptor for IgE on mast cells. II. Demonstration of the specific binding of IgE to cell-free particulate preparations from rat peritoneal mast cells.

1973 • 30 citations

Reaginic Antibody Formation in the Mouse

1976 • 29 citations

Characterization of the Target Cell Receptor for IgE

1978 • 25 citations

Regulation of antibody response in vitro. II. Formation of rabbit reaginic antibody.

1972 • 24 citations

Effect of reduction upon the PCA-blocking activity of immunoglobulin E

1970 • 24 citations

IgE formation in the rat after infection with Nippostrongylus brasiliensis. II. Proliferation of IgE-bearing cells in neonatally thymectomized animals.

1977 • 23 citations

Hapten-Specific IgE Antibody Responses in Mice

1974 • 22 citations

Regulation of Antibody Response in Different Immunoglobulin Classes

1977 • 21 citations

Hapten-Specific IgE Antibody Responses in Mice

1974 • 21 citations

Ontogeny of IgE-Bearing Lymphocytes in the Rat

1978 • 20 citations

Evidence for Antibody Activity against the Receptor for IgE in a Rabbit Antiserum Prepared against IgE-Receptor Complexes

1978 • 20 citations

IgE formation in the rat following infection with Nippostrongylus brasiliensis. III. Soluble factor for the generation of IgE-bearing lymphocytes.

1977 • 19 citations

Regulation of Antibody Response in Vitro

1972 • 19 citations

Reaginic antibody formation in the mouse. X. Possible role of suppressor T cells in transient IgE antibody responses.

1978 • 17 citations

Regulation of Antibody Response in Different Immunoglobulin Classes

1977 • 17 citations

IgE Formation in the Rat After Infection with Nippostrongylus Brasiliensis

1977 • 17 citations

Regulation of Antibody Response in Vitro

1972 • 16 citations

Binding of rat IgE with the subcellular components of normal rat mast cells

1976 • 16 citations

IgE-B cell-generating factor from lymph node cells of rats infected with Nippostrongylus brasiliensis. I. Source of IgE-B cell-generating factor.

1978 • 15 citations

Role of IgE and IgG Antibodies in Reaginic Hypersensitivity in the Respiratory Tract

1973 • 15 citations

On the Nature of the Presumed Receptor for IgE on Mast Cells

1973 • 15 citations

IgE Formation in the Rat Following Infection with Nippostrongylus Brasiliensis

1977 • 15 citations

Reaginic Antibody Formation in the Mouse

1978 • 13 citations

Reaginic Antibody Formation in the Mouse

1976 • 12 citations

IgE-B cell-generating factor from lymph node cells of rats infected with Nippostrongylus brasiliensis. II. Effector mechanisms of IgE-B cell-generating factor.

1978 • 11 citations

Reaginic antibody formation in the mouse. IX. Enhancement of suppressor and helper cell activities of primed spleen cells.

1977 • 9 citations

IgE-B Cell-Generating Factor from Lymph Node Cells of Rats Infected with Nippostrongylus Brasiliensis

1978 • 9 citations

IgE-B Cell-Generating Factor from Lymph Node Cells of Rats Infected with Nippostrongylus Brasiliensis

1978 • 5 citations

Reaginic Antibody Formation in the Mouse

1977 • 5 citations

Effect of bee envenomation on local tissue response in varicella

1968 • 2 citations