Dietary Influences on Prostaglandin Synthesis

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

THE TROMSØHEART-STUDY

1977 • 1,212 citations

Form and function of phospholipids

1973 • 1,072 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

Isolation and properties of intermediates in prostaglandin biosynthesis

1973 • 796 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Distribution and fatty acid composition of phosphoglycerides in normal human brain

1968 • 623 citations

The Tromsø Heart Study

1983 • 500 citations

Role of Fats in Human Nutrition

1989 • 464 citations

Metabolism of [14C]arachidonic acid by human platelets

1976 • 453 citations

Essential fatty acid deficiency

1971 • 440 citations

Visual Membranes: Specificity of Fatty Acid Precursors for the Electrical Response to Illumination

1975 • 370 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Polyunsaturated Fatty Acids

2015 • 349 citations

Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology

1974 • 315 citations

Effect of Linolenic Acid Upon the Metabolism of Linoleic Acid

1963 • 309 citations

The enzymic conversion of all‐cis 8,11,14‐eicosatrienoic acid into prostaglandin E₁

1966 • 307 citations

Structure of leukotriene C identification of the amino acid part

1979 • 304 citations

Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin

1979 • 285 citations

Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle

1973 • 275 citations

THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS

1977 • 264 citations

Coronary heart disease — The global picture

1975 • 247 citations

The Role of Fats in Human Nutrition.

1976 • 245 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: Reciprocal replacement of n−6 and n−3 polyunsaturated fatty acids

1971 • 226 citations

Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis

1973 • 221 citations

Biological Significance of the Prostaglandins

1970 • 207 citations

Cyclic adenosine 3′,5′-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets

1977 • 204 citations

Biochemical aspects of drug and hormone action on adipose tissue.

1973 • 200 citations

NUTRITIONAL AND METABOLIC INTERRELATIONSHIPS BETWEEN FATTY ACIDS.

1964 • 198 citations

Inhibition of prostaglandin synthesis by oleic, linoieic and linoienic acids

1968 • 187 citations

The Enzymatic Conversion of Essential Fatty Acids into Prostaglandins

1964 • 178 citations

Polyunsaturated Fatty Acids

2020 • 177 citations

Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis

1975 • 163 citations

Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency

1972 • 159 citations

Incorporation of long-chain and polyunsaturated acids into phosphatidate and phophatidylcholine

1968 • 158 citations

INFLUENCE OF DIETARY FAT ON PLATELET FUNCTION IN MEN

1973 • 153 citations

Antithrombotic potential of dihomo-gamma-linolenic acid in man.

1977 • 152 citations

Cofactor Requirements of the Enzyme Synthesizing Prostaglandin in Bovine Seminal Vesicles

1970 • 148 citations

BRAIN LIPID MODIFICATIONS INDUCED BY ESSENTIAL FATTY ACID DEFICIENCY IN GROWING MALE AND FEMALE RATS

1970 • 145 citations

Specificity in the enzymic conversion of polyunsaturated fatty acids into prostaglandins

1966 • 137 citations

Reduction in blood pressure associated with high polyunsaturated fat diets that reduce blood cholesterol in man

1975 • 133 citations

Polyethenoid fatty acid metabolism. VI. Effect of pyridoxine on essential fatty acid conversions

1952 • 132 citations

Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase

1977 • 130 citations

A comparison of acyltransferase activities in vitro with the distribution of fatty acids in lecithins and triglycerides in vivo

1966 • 123 citations

Biosynthesis of prostaglandin E2 in human skin: subcellular localization and inhibition by unsaturated fatty acids and anti-inflammatory drugs

1973 • 121 citations

Prostaglandins: Physiological Pharmacological and Pathological Aspects

1976 • 120 citations

Regulation of the Arachidonic Acid Cascade

1977 • 115 citations

Prostaglandin Synthetase System—Resolution into Oxygenase and Isomerase Components

1974 • 112 citations

Effects of Ethylenic Bond Position upon Acyltransferase Activity with Isomeric cis, cis-Octadecadienoyl Coenzyme A Thiol Esters

1968 • 109 citations

Acrodermatitis enteropathica: Defective metabolism of unsaturated fatty acids

1969 • 106 citations

The biosynthesis and possible function of prostaglandins in adipose tissue

1970 • 106 citations

The role of copper in prostaglandin synthesis

1973 • 102 citations

Radioimmunoassay of prostaglandins E1, E2, and F2α in unextracted plasma, serum and myocardium

1976 • 100 citations

Synthesis of prostaglandins by the rat renal papilla in vitro

1975 • 97 citations

Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors

1975 • 96 citations

The relationship of dietary fats to prostaglandin biosynthesis

1979 • 96 citations

Linoleate Enrichment of Diet and Prostaglandin Metabolism in Rats

1975 • 95 citations

A Hypothesis Involving Competitive Inhibitions in the Metabolism of Polyunsaturated Fatty Acids.

1963 • 92 citations

Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats

1974 • 90 citations

Inhibition of prostaglandin biosynthesis by 8cis, 12trans, 14cis-eicosatrienoic acid and 5cis, 8cis, 12trans, 14cis-eicosatetraenoic acid

1970 • 89 citations

Selective incorporation of 14C-arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to 14C-prostaglandins

1976 • 87 citations

Relationship between the type of dietary fatty acid and arterial thrombosis tendency in rats

1975 • 85 citations

Influence of dietary vitamin E on prostaglandin biosynthesis in rat blood

1975 • 81 citations

Acquired zinc deficiency. Cutaneous manifestations typical of acrodermatitis enteropathica

1976 • 81 citations

Metabolism of the Geometric Isomers of Linoleic Acid in the Rat

1967 • 80 citations

Prostaglandins: Physiological, Pharmacological and Pathological Aspects.

1977 • 80 citations

EFFECT OF A DIET OF POLYUNSATURATED FATS ON SOME PLATELET-FUNCTION TESTS

1976 • 78 citations

Effects of prostaglandin deficiency on natriuresis, diuresis, and blood pressure

1974 • 78 citations

The Thrombotic Process in Atherogenesis

1978 • 75 citations

Hypotensive effect of dietary prostaglandin precursor in hypertensive man

1978 • 74 citations

Radioimmunoassay of prostaglandins

1978 • 73 citations

Essential fatty acids, diabetes, and cholesterol

1955 • 73 citations

Acquired Zinc Deficiency

1976 • 73 citations

Essential Fatty Acid Deficiency

1958 • 71 citations

Unsaturated fatty acids in multiple sclerosis.

1973 • 71 citations

Dietary manipulation of prostaglandin and thromboxane synthesis in heart, aorta and blood platelets of the rat.

1980 • 69 citations

An Investigation of the Essential Fatty Acid Activity of Some of the Geometrical Isomers of Unsaturated Fatty Acids

1960 • 66 citations

The role of prostaglandin endoperoxides and thromboxanes in platelet aggregation.

1976 • 65 citations

Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors

1977 • 64 citations

Effects of feeding ethyl-dihomo-γ-linolenate on prostaglandin biosynthesis and platelet aggregation in the rabbit

1976 • 62 citations

The biosynthesis of prostaglandins by brain tissue in vitro.

1976 • 59 citations

Hypercoagulability Induced by Hyperlipemia in Rat, Rabbit and Man

1970 • 56 citations

THE RELEASE OF BRAIN FREE FATTY ACIDS DURING ISCHAEMIA IN ESSENTIAL FATTY ACID‐DEFICIENT RATS

1976 • 55 citations

The activity of γ-linolenate and dihomo-γ-linolenate methyl esters in vitro and in vivo on blood platelet function in non-human primates and in man

1977 • 53 citations

Vascular responses to arachidonic acid in the perfused canine lung.

1976 • 53 citations

Effects of Arachidonic Acid on Systemic Arterial Pressure, Myocardial Contractility and Platelets in the Dog

1974 • 53 citations

Acceleration of Essential Fatty Acid Deficiency by Dietary Cholesterol

1960 • 50 citations

Progress in the chemistry of fats and other lipids. Vol. 2

1954 • 49 citations

Chain Elongation of α- and γ-Linolenic Acids and the Effect of Other Fatty Acids on Their Conversion in Vitro

1968 • 48 citations

Effect of the stress of unilateral adrenalectomy on the depletion of individual cholesteryl esters in the rat adrenal

1969 • 46 citations

Some investigations into the role of prostacyclin in thromboregulation

1978 • 46 citations

The role of fat in human nutrition

1946 • 45 citations

Effect of Essential Fatty Acid Deficiency and Type of Dietary Fat Supplementation on Biotin-deficient Chicks

1971 • 43 citations

Rat platelets aggregate in the absence of endogenous precursors of prostaglandin endoperoxides

1976 • 42 citations

Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet

1974 • 41 citations

The role of iron in prostaglandin synthesis: Ferrous iron mediated oxidation of arachidonic acid

1978 • 40 citations

Effects of Non-essential Fatty Acids on Essential Fatty Acid Deficiency

1965 • 39 citations

Metabolism of Linoleic Acid in Relation to Dietary Monoenoic Fatty Acids in the Rat

1967 • 38 citations

In vitro biosynthesis of prostaglandin E₂ by kidney medulla of essential fatty acid deficient rats

1976 • 37 citations

On the blood pressure response of salt-loaded rats under different content of linoleic acid in the food.

1976 • 35 citations

Mechanism underlying the inhibition of platelet aggregation by eicosapentaenoic acid and its metabolites.

1980 • 35 citations

The use of essential fatty acid deficient rats to study pathophysiological roles of prostaglandins. Comparison of prostaglandin production with some parameters of deficiency

1979 • 34 citations

A mass fragmentographic method for the quantitative evaluation of brain prostaglandin biosynthesis

1975 • 33 citations

Effect of dietary linoleic acid deficiency on platelet aggregation and phospholipid fatty acid of rats

1978 • 33 citations

Hepatoma, host liver, and normal rat liver lipids: Distribution of isomeric monoene fatty acids in individual lipid classes

1975 • 33 citations

Medical Studies in North Greenland 1948–1949

1951 • 32 citations

Dietary Fats and Experimental (Cardiac and Venous) Thrombosis

1973 • 32 citations

Decreased Prostaglandin E Turnover in Infants with Essential Fatty Acid Deficiency

1978 • 32 citations

Platelet dysfunction in the neonate with essential fatty acid deficiency

1977 • 31 citations

Synthesis of thromboxane A2 by non-aggregating dog platelets challenged with arachidonic acid or with prostaglandin H2

1977 • 30 citations

Absence of the biochemical symptoms of essential fatty acid deficiency in surgical patients undergoing protein sparing therapy

1977 • 30 citations

The effect of essential fatty acid‐deficient diet on the levels of prostaglandins and their fatty acid precursors in the rabbit brain

1979 • 29 citations

Studies on the synthesis of prostaglandins in the vesicular glands of essential fatty acid-deficient and hypophysectomized rats

1973 • 27 citations

Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis

1978 • 27 citations

Total Serum Fatty Acids in Diabetes

1968 • 26 citations

Different utilization of arachidonic and dihomogammalinolenic acids by human platelet prostaglandin synthetase

1978 • 26 citations

The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclic 3′,5′-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats

1975 • 25 citations

Decreased Susceptibility to Thrombin and Collagen Platelet Aggregation in Man Fed a Low Fat Diet

1974 • 24 citations

The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclic 3′,5′-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats

1975 • 24 citations

The influence of saturated fatty acids on prostaglandin synthetase activity

1975 • 24 citations

Prostaglandin production and lipolysis in isolated rat adipocytes as affected by dietary fat

1978 • 23 citations

A raised level of free fatty acids in serum of rats deficient in essential fatty acids as a contributing cause of their fatty livers

1965 • 23 citations

An imbalance in arachidonic acid metabolism in diabetes.

1980 • 23 citations

Effect of Prostaglandins in Urate Crystal Inflammation

1974 • 22 citations

Essential fatty acids in maternal diet and in rat milk phospholipids

1974 • 21 citations

Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets

1978 • 21 citations

Dietary essential fatty acids, polyunsaturated fatty acids, and prostaglandins in the central nervous system.

1978 • 20 citations

Isolation of glucose-sensitive platelet lipoxygenase products from arachidonic acid.

1980 • 20 citations

Effects of infusion of some prostaglandins in essential fatty acid-deficient and normal rats

1968 • 20 citations

Inhibition of prostaglandin biosynthesis by c−5, c−8, c−11-eicosatrienoic acid

1978 • 19 citations

Effects of Dietary Fats on the Coronary Flow Rate and the Left Ventricular Function of the Isolated Rat Heart

1979 • 18 citations

Effect of Essential and Nonessential Fatty Acids in Complex Mixture on Fatty Acid Composition of Liver Lipids

1976 • 18 citations

Dietary fat type and ambient oxygen tension influence pulmonary prostaglandin synthetic potential

1978 • 17 citations

Formation by phospholipase A2 of prostaglandins and thromboxane A2-like activity in the platelets of normal and essential fatty acid deficient rats. Comparison with effect on human and rabbit platelets

1977 • 17 citations

Effects of Pyridoxine Deficiency on the Composition of Plasma and Liver Fatty Acids in Rats Fed Low and High Fat Diets

1975 • 16 citations

Hypersensitivity to lipid mobilizing agents in essential fatty acid (EFA) deficient rats

1967 • 16 citations

Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs

1977 • 14 citations

Pilot Epidemiological Studies in Thrombosis

1978 • 13 citations

EFFECTS OF FOOD ANTIOXIDANTS ON PROSTAGLANDIN BIOSYNTHESIS

1977 • 13 citations

Ascorbic acid and PGF2alpha antagonism on tracheal smooth muscle.

1976 • 13 citations

The influence of unsaturated fatty acids on prostaglandin-release in isolated perfused guinea-pig hearts

1977 • 12 citations

Effect of dietary rapeseed oil on the adrenocorticotrophin-induced production of prostaglandins in the rat adrenal

1972 • 12 citations

Studies on the relationship of the synthesis of prostaglandins to the biological activity of essential fatty acids

1972 • 11 citations

The effects of trans linoleic acid on the concentration of serum prostaglandin f2α and platelet aggregation

1978 • 11 citations

Regulation of prostaglandin E2 biosynthesis in guinea pig skin by retinoic acid.

1975 • 10 citations

The effect of kind of dietary carbohydrate upon the composition of liver fatty acids of the rat

1965 • 9 citations

The effect of long‐chain monoenes on prostaglandin E₂ synthesis by rat skin

1977 • 8 citations

Effect of Pyridoxine on Red Cell Fatty Acid Composition in Mature Rats Fed an Essential Fatty Acid-deficient Diet

1973 • 7 citations

Stimulation of rabbit renal PGE2 biosynthesis by dietary restriction of sodium.

1980 • 5 citations

Levels of prostaglandins and their precursors in EFA-deficient rabbits--a new concept of prostaglandin biosynthesis [proceedings].

1978 • 5 citations

Effect of fatty acids on the contraction of guinea-pig ileum in vitro

1970 • 5 citations

Influence of linoleic acid rich or linoleic acid low diet on doca hypertension and the prostaglandin synthetase and dehydrogenase activity in the rat kidney

1975 • 3 citations

Influence of a linoleic acid (LA) supplemented diet on heart rate, contractile force, coronary flow and prostaglandin (PG) release of rat hearts

1977 • 3 citations

Lipid Metabolism

1973 • 3 citations

Testis requirement for vitamin A in the rat and the effect of essential fatty acid.

1968 • 2 citations

IMMUNOLOGIC MARKERS AND MORPHOLOGY IN CHILDHOOD LYMPHOBLASTIC LYMPHOMA

1978 • 1 citations