Chemical Modifications of Bovine Trypsinogen and Trypsin

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin

1967 • 848 citations

Tetranitromethane. A Reagent for the Nitration of Tyrosyl Residues in Proteins^*

1966 • 635 citations

Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from N^α-Tosyl-L-lysine^*

1965 • 521 citations

Water-Insoluble Derivatives of Enzymes, Antigens, and Antibodies

1966 • 475 citations

The Use of Cyanate for the Determination of NH2-terminal Residues in Proteins

1963 • 472 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

N-Acetylimidazole: A Reagent for Determination of “Free” Tyrosyl Residues of Proteins^*

1965 • 335 citations

Functional Tyrosyl Residues in the Active Center of Bovine Pancreatic Carboxypeptidase A^*

1963 • 302 citations

TRYPSINOGEN AND CHYMOTRYPSINOGEN AS HOMOLOGOUS PROTEINS

1964 • 292 citations

Conversion of 3-nitrotyrosine to 3-aminotyrosine in peptides and proteins

1967 • 252 citations

A Water-insoluble Polyanionic Derivative of Trypsin. I. Preparation and Properties^*

1964 • 239 citations

IDENTIFICATION OF A PEPTIDE RELEASED DURING AUTOCATALYTIC ACTIVATION OF TRYPSINOGEN

1955 • 236 citations

Evolution of Structure and Function of Proteases

1967 • 197 citations

[3] Trypsinogen and trypsin

1955 • 192 citations

Synthesis of Biologically Active Cellulose Derivatives of Enymes

1961 • 177 citations

Preparation and Properties of Water-insoluble Derivatives of Trypsin

1963 • 175 citations

The Mechanism of Activation of Trypsinogen. The Role of the Four N-Terminal Aspartyl Residues

1969 • 163 citations

Evolutionary Similarities between Pancreatic Proteolytic Enzymes

1965 • 156 citations

DISULFIDE INTERCHANGE AND THE THREE-DIMENSIONAL STRUCTURE OF PROTEINS

1965 • 152 citations

Covalent structure of bovine trypsinogen. The position of the remaining amides

1966 • 141 citations

Sites of Binding of Copper(II) Ion by Peptide (1–24) of Bovine Serum Albumin

1968 • 110 citations

Enzyme envelopes on colloidal particles

1969 • 88 citations

THE EFFECT OF CALCIUM AND OTHER IONS ON THE AUTOCATALYTIC FORMATION OF TRYPSIN FROM TRYPSINOGEN

1941 • 83 citations

Preparation of Chemically Defined ɛN‐Acetylated Trypsin

1967 • 82 citations

The binding of Ca2 to trypsinogen and its relation to the mechanism of activation

1967 • 80 citations

USE OF „REPORTER GROUPS” IN STRUCTURE-FUNCTION STUDIES OF PROTEINS

1964 • 78 citations

Sur la séquence N-terminale du trypsinogéne et son ablation pendant l'activation de ce zymogéne

1955 • 55 citations

Identification of the histidine residue at the active center of trypsin labelled by TLCK

1967 • 54 citations

Covalent structure of bovine trypsinogen

1966 • 49 citations

ACETYL-CHYMOTRYPSIN

1955 • 43 citations

Reaction of trypsin with bromoacetone

1968 • 42 citations

The Kinetics of the Trypsin-Catalyzed Hydrolysis of p-Nitrophenyl α-N-Benzyloxycarbonyl-L-lysinate Hydrochloride¹

1965 • 34 citations

The reaction of tyrosyl residues of bovine trypsin and trypsinogen with tetranitromethane

1968 • 30 citations

‘Buried’ Tyrosyl Residues and the Activity of Trypsin

1965 • 30 citations

Relief by modification of carboxylate groups of the calcium requirement for the activation of trypsinogen

1967 • 21 citations

Effects of acetylation on the activity of trypsin toward ester and amide substrates

1969 • 18 citations

An acetyl-peptide from acetylchymotrypsin

1962 • 18 citations

Homology and Phylogeny of Proteolytic Enzymes

1970 • 15 citations

A partially active trypsin induced by limited acetylation

1966 • 13 citations

‘Active Centre’ Studies in Trypsin

1961 • 9 citations

The Role of Carboxylates and Phenol Side-chains in the Activity and Conformation of Trypsinogen, Trypsin, Chymotrypsinogen, and Chymotrypsin

1970 • 5 citations

The inhibition of trypsinogen activation by low concentrations of urea

1969 • 5 citations