The Molecular Structure and Regulation of Muscular Calcium Channels

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling

1973 • 978 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscle

1987 • 887 citations

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

1984 • 834 citations

Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA

1988 • 803 citations

Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle.

1988 • 768 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules

1984 • 469 citations

Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle.

1987 • 468 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Calcium channels: Molecular pharmacology, structure and regulation

1988 • 382 citations

[3H]nitrendipine receptors in skeletal muscle.

1983 • 381 citations

Primary Structure of the β Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1989 • 371 citations

Regulation of Cardiac L-Type Calcium Current by Phosphorylation and G Proteins

1990 • 359 citations

Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs.

1986 • 347 citations

Cloning of a probable potassium channel gene from mouse brain

1988 • 304 citations

Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

1989 • 297 citations

Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons

1987 • 283 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels

1985 • 264 citations

Modulation of Ca current during the phosphorylation cycle in the guinea pig heart

1986 • 254 citations

Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase.

1985 • 253 citations

Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems.

1988 • 252 citations

Calcium Channel Ligands

1987 • 249 citations

Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila

1987 • 244 citations

PEPTIDE TOXINS FROM VENOMOUS CONUS SNAILS

1988 • 234 citations

Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers.

1986 • 217 citations

Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.

1988 • 196 citations

Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.

1986 • 190 citations

Expression and Modulation of Voltage-Gated Calcium Channels After RNA Injection in Xenopus Oocytes

1986 • 174 citations

Calcium currents in embryonic and neonatal mammalian skeletal muscle.

1988 • 165 citations

Subunits of purified calcium channels: a 212-kDa form of alpha 1 and partial amino acid sequence of a phosphorylation site of an independent beta subunit.

1989 • 157 citations

Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.

1988 • 147 citations

Regulation of the L-type calcium channel

1987 • 147 citations

Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+) [3H]PN 200-110

1984 • 139 citations

Effect of postnatal development on calcium currents and slow charge movement in mammalian skeletal muscle.

1988 • 139 citations

Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation‐contraction coupling.

1988 • 136 citations

Modulation of calcium channels of twitch skeletal muscle fibres of the frog by adrenaline and cyclic adenosine monophosphate.

1987 • 134 citations

Calcium currents, charge movement and dihydropyridine binding in fast‐ and slow‐twitch muscles of rat and rabbit.

1987 • 132 citations

Site‐specific phosphorylation of the purified receptor for calcium‐channel blockers by cAMP‐ and cGMP‐dependent protein kinases, protein kinase C, calmodulin‐dependent protein kinase II and casein kinase II

1988 • 131 citations

Activation of purified calcium channels by stoichiometric protein phosphorylation.

1989 • 131 citations

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

1986 • 131 citations

The Calcium Channel: Structure, Function and Implications

1988 • 130 citations

Control of voltage‐dependent Ca ²⁺ channels by G protein‐coupled receptors

1988 • 126 citations

Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle. Evidence for a 52,000 Da subunit.

1988 • 120 citations

The 165‐KDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel

1987 • 117 citations

Subcellular distribution of the 1,4-dihydropyridine receptor in rabbit skeletal muscle in situ: an immunofluorescence and immunocolloidal gold-labeling study.

1989 • 117 citations

Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse‐tubule calcium channel

1987 • 114 citations

Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers.

1988 • 112 citations

Purification of a functional receptor for calcium‐channel blockers from rabbit skeletal‐muscle microsomes

1986 • 107 citations

Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different.

1988 • 107 citations

Paralysis of frog skeletal muscle fibres by the calcium antagonist D‐600.

1983 • 103 citations

Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C

1987 • 103 citations

Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.

1985 • 98 citations

Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent calcium channels in skeletal, cardiac, and smooth muscles

1986 • 96 citations

Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cells in culture: electrophysiological properties and interactions with Ca2+ channel activator (Bay K8644) and inhibitor (PN 200-110).

1986 • 96 citations

cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers.

1988 • 90 citations

Stereoselective photoaffinity labelling of the purified 1,4‐dihydropyridine receptor of the voltage‐dependent calcium channel

1986 • 90 citations

A fast‐activated inward calcium current in twitch muscle fibres of the frog (Rana montezume).

1986 • 84 citations

Characterization of the 1,4-dihydropyridine receptor using subunit-specific polyclonal antibodies

1989 • 84 citations

Properties of structure and interaction of the receptor for ω-conotoxin, a polypeptide active on Ca 2+ channels

1988 • 83 citations

The bovine cardiac receptor for calcium channel blockers is a 195‐kDa protein

1988 • 77 citations

Purified calcium channels have three allosterically coupled drug receptors

1986 • 75 citations

Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.

1987 • 72 citations

Effects of the calcium antagonist gallopamil (D600) upon excitation‐contraction coupling in toe muscle fibres of the frog.

1987 • 71 citations

Heterogeneity of conductance states in calcium channels of skeletal muscle

1988 • 69 citations

Characterization of the omega-conotoxin-binding molecule in rat brain synaptosomes and cultured neurons.

1988 • 62 citations

(—)‐[³H]Desmethoxyverapamil, a novel Ca²⁺ channel probe

1984 • 60 citations

Phosphorylation of the 165-kDa dihydropyridine/phenylalkylamine receptor from skeletal muscle by protein kinase C.

1988 • 57 citations

Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation

1987 • 47 citations

Specific Block of Calcium Channel Expression by a Fragment of Dihydropyridine Receptor cDNA

1989 • 42 citations

Monoclonal antibody to the alpha 1-subunit of the dihydropyridine-binding complex inhibits calcium currents in BC3H1 myocytes.

1988 • 39 citations

Putative calcium channel molecular weight determination by target size analysis

1983 • 39 citations

Photoaffinity labelling of the cardiac calcium channel. (−)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand

1987 • 38 citations

Solubilization of the omega-conotoxin receptor associated with voltage-sensitive calcium channels from bovine brain.

1988 • 31 citations

Structure, Function, and Regulation of the Skeletal Muscle Dihydropyridine Receptor^a

1989 • 28 citations

The effect of the phenylalkylamine D888 (devapamil) on force and Ca2+ current in isolated frog skeletal muscle fibres.

1989 • 28 citations

Photoaffinity-labelling of the calcium-channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus. A 195 kDa polypeptide carries both drug receptors and has similarities to the α1 subunit of the purified skeletal-muscle calcium channel

1988 • 27 citations

Calcium Channels Reconstituted from the Skeletal Muscle Dihydropyridine Receptor Protein Complex and Its α₁ Peptide Subunit in Lipid Bilayers^a

1989 • 26 citations

Monoclonal antibodies against the 1,4‐dihydropyridine receptor associated with voltage‐sensitive Ca²⁺ channels detect similar polypeptides from a variety of tissues and species

1987 • 22 citations

Purification and affinity labeling of dihydropyridine receptor from rabbit skeletal muscle membranes.

1988 • 14 citations

Special Topic: Genetic Analysis of Voltage-Sensitive Ion Channels

1988 • 8 citations

Genetic Analysis of Ion Channels in Vertebrates

1988 • 6 citations

Direct hormonal regulation of smooth muscle calcium current

1989 • 3 citations

78. Konferenz der Gesellschaft für Biologische Chemie. Studiengruppe Biochemische Pharmakologie und Toxikologie. Eicosanoids and Cytokines

1989 • 1 citations