Inactivation of single-chain urokinase (pro-urokinase) by thrombin and thrombin-like enzymes: relevance of the findings to the interpretation of fibrin-binding experiments

Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species.

1984 • 313 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor.

1984 • 193 citations

Purification and partial characterization of a single-chain high-molecular-weight form of urokinase from human urine

1983 • 185 citations

Pro-urokinase: a study of its stability in plasma and of a mechanism for its selective fibrinolytic effect

1986 • 173 citations

Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin.

1985 • 138 citations

Studies on a procoagulant fraction of southern copperhead snake venom: the preferential release of fibrinopeptide B.

1970 • 136 citations

Urokinase-related proteins in human urine. Isolation and characterization of single-chain urokinase (pro-urokinase) and urokinase-inhibitor complex.

1986 • 126 citations

Mechanism of ancrod anticoagulation

1972 • 73 citations

Spontaneous fibrinolysis in whole human plasma. Identification of tissue activator-related protein as the major plasminogen activator causing spontaneous activity in vitro.

1985 • 73 citations

Fibrin Binding and Zymogenic Properties of Single-Chain Urokinase (Pro-urokinase)

1987 • 14 citations

Purification Of High Affinity Plasminogen Activator (HAPA) From Blood By Affinity Chromatography On Fibrin-Celite

1981 • 3 citations