Temperature-Sensitive Mutations in Animal Cells

Control of proliferation in animal cells

1974 • 1,177 citations

Physiological Studies of Conditional Lethal Mutants of Bacteriophage T4D

1963 • 808 citations

The molecular biology of tumor viruses

1974 • 734 citations

Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast

1967 • 728 citations

Sensitive mutants of bacteriophage λ

1961 • 710 citations

X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALS

1972 • 657 citations

THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES

1958 • 634 citations

Progress in immunology

1968 • 577 citations

Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants

1970 • 547 citations

Molecular Basis of Mutation

1970 • 349 citations

THE MOLECULAR BASIS OF MUTATION

1972 • 315 citations

A Unifying Hypothesis Concerning the Nature of Malignant Growth

1972 • 282 citations

REGULATION OF INITIATION OF DNA SYNTHESIS IN CHINESE HAMSTER CELLS

1970 • 271 citations

A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

1972 • 266 citations

Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability.

1968 • 256 citations

Fluorinated Pyrimidines

1965 • 252 citations

TEMPERATURE-SENSITIVE MUTANTS OF BACTERIOPHAGE T4D: THEIR ISOLATION AND GENETIC CHARACTERIZATION

1964 • 251 citations

Temperature-Sensitive Mutations in Drosophila melanogaster

1970 • 239 citations

Chapter 7: Isolation of Mutants of Cultured Mammalian Cells

1973 • 232 citations

Genetics of somatic mammalian cells. V. Treatment with 5-bromodeoxyuridine and visible light for isolation of nutritionally deficient mutants.

1967 • 222 citations

The effect of-beta-D-arabinofuranosylcytosine on growth, viability, and DNA synthesis of mouse L-cells.

1970 • 209 citations

A COMPARATIVE GENETIC STUDY OF CONDITIONAL LETHAL MUTATIONS OF BACTERIOPHAGE T4D

1964 • 188 citations

A Mammalian Cell Mutant with a Temperature-Sensitive Leucyl-Transfer RNA Synthetase

1973 • 169 citations

Studies on thymidine kinase in cultured mouse fibroblasts

1965 • 162 citations

Altered Enzymes in Drug-Resistant Variants of Mammalian Tissue Culture Cells

1973 • 158 citations

Temperature Sensitive Mutants of BHK 21 Cells

1972 • 138 citations

Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells

1974 • 133 citations

A temperature‐sensitive cell cycle mutant of the BHK cell line

1974 • 132 citations

SOME RECENT STUDIES BEARING ON THE ONE GENE-ONE ENZYME HYPOTHESIS

1951 • 128 citations

Biochemical Genetics of Neurospora

1950 • 115 citations

Isolation of Temperature-Sensitive Mutants of L-Cells

1970 • 108 citations

Mutation Causing Temperature-Sensitive Expression of Cell Transformation by a Tumor Virus

1972 • 96 citations

Induction of Auxotrophic Mutations by Treatment of Chinese Hamster Cells with 5-Bromodeoxyuridine and Black Light

1972 • 86 citations

Mutant chinese hamster cells with a thermosensitive hypoxanthine-guanine phosphoribosyltransferase

1975 • 83 citations

A Temperature-Sensitive Mutation Affecting 28S Ribosomal RNA Production in Mammalian Cells

1973 • 81 citations

Selection by [3H] amino acids of CHO-cell mutants with altered leucyl- and asparagyl-transfer RNA synthetases

1975 • 77 citations

Malignant Transformation of BHK ₂₁ Clone 13 Cells In Vitro by Nitrosamines—A Conditional State

1973 • 74 citations

Conditionally lethal mutations in chinese hamster cells. I. Isolation of a temperature-sensitive line and its investigation by cell cycle studies

1973 • 68 citations

Production of an Altered Pantothenate-Synthesizing Enzyme by a Temperature-Sensitive Mutant of Escherichia Coli

1952 • 67 citations

Selective and nonselective isolation of temperature‐sensitive mutants of mouse L‐cells and their characterization

1971 • 65 citations

Preliminary characterization of the temperature-sensitive defect in DNA replication in a mutant mouse L cell

1976 • 64 citations

Temperature-sensitive Mammalian Cell Line Blocked in Mitosis

1974 • 63 citations

A temperature‐sensitive function in a Chinese hamster line affecting DNA synthesis

1973 • 60 citations

Temperature-sensitive mutants of Balb/3T3 cells: Description of a mutant affected in cellular and polyoma virus DNA synthesis

1976 • 59 citations

Temperature Sensitive Conditional Mutants of Monkey Kidney Cells

1969 • 58 citations

A cell line which is temperature‐sensitive for cytokinesis

1972 • 57 citations

Isolation of temperature sensitive mammalian cells by selective detachment

1973 • 55 citations

A mammalian somatic “cell cycle” mutant defective in G₁

1974 • 54 citations

DNA synthesis and mitosis in a temperature sensitive Chinese hamster cell line

1973 • 54 citations

Temperature-sensitive cell cycle mutants: a chinese hamster cell line with a reversible block in cytokinesis

1975 • 54 citations

Temperature-Sensitive Variants of an Established Myoblast Line

1973 • 43 citations

Characterization of a chinese hamster cell with a temperature-sensitive mutation in folate metabolism

1974 • 40 citations

Conditional lethal mutants of Chinese hamster cells: Mutants requiring exogenous carbondioxide for growth

1974 • 39 citations

Surface Changes in Temperature-Sensitive Simian Virus 40-Transformed Cells

1973 • 38 citations

Alternate temporal order in ribosomal RNA maturation

1976 • 38 citations

Mapping of the G1 phase of a mammalian cell cycle

1975 • 35 citations

Comparative Killing Efficiencies for Decays of Tritiated Compounds Incorporated into E. coli

1963 • 33 citations

TEMPERATURE-SENSITIVE MUTATIONS IN Drosophila melanogaster , III. DOMINANT LETHALS AND SEMILETHALS ON CHROMOSOME 2

1969 • 33 citations

In vitro malignant transformation of cells by chemical carcinogens

1974 • 32 citations

Temperature-sensitive mutants of chemically transformed epithelial cells.

1975 • 32 citations

Studies on a chinese hamster line that is temperature sensitive for the commitment to DNA synthesis

1974 • 31 citations

Retransformation of ts SV40 Transformants by Murine Sarcoma Virus at Non-permissive Temperature

1972 • 29 citations

TEMPERATURE-SENSITIVE MUTANTS OF A CHINESE HAMSTER CELL LINE. I. SELECTION OF CLONES WITH DEFECTIVE MACROMOLECULAR BIOSYNTHESIS

1975 • 29 citations

Mutant hamster cells exhibiting a pleiotropic effect on carbohydrate metabolism.

1975 • 27 citations

Temperature-Sensitive Simian Virus 40-Transformed Cells: Phenomena Accompanying Transition from the Transformed to the “Normal” State

1973 • 26 citations

Chapter 1 Methods for Selecting and Studying Temperature-Sensitive Mutants ofBHK-21 Cells

1974 • 26 citations

Processing of ribosomal RNA in a temperature sensitive mutant of BHK cells

1976 • 25 citations

Micro-scale peptide mapping method for identification of variant proteins

1971 • 25 citations

Transformation by polyoma virus alters expression of a cell mutation affecting cycle traverse.

1975 • 25 citations

Selection for temperature‐sensitive mutants of diploid and tetraploid mammalian cells

1974 • 24 citations

Characterization of a temperature-sensitive mutant of BALB/c 3T3 cells

1973 • 24 citations

Temperature-sensitive cell mutations that inhibit adenovirus 2 replication.

1975 • 24 citations

Complementation of a defect in the production of ribosomal RNA in somatic cell hybrids

1974 • 23 citations

Early Functional Mutants of Mammalian Cells

1973 • 23 citations

Effect of leucine on the temperature sensitive phenotype of a mammalian leucyl‐tRNA synthetase mutant

1975 • 22 citations

Isolation of heat- and cold-sensitive mutants of chinese hamster lung cells affected in their ability to express the transformed state

1975 • 22 citations

Initial Characterization of a Temperature Sensitive Mutant of Monkey Kidney Cell

1970 • 21 citations

Viral Transformation and Endogenous Viruses

1974 • 21 citations

Isolation and characterization of temperature-sensitive mutants in a Chinese hamster cell line

1973 • 19 citations

SV40-transformed cells with temperature-dependent serum requirements

1975 • 18 citations

Isolation of cold-sensitive Chinese hamster cells

1975 • 18 citations

Evidence for linkage between glucose 6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyl transferase loci in Chinese hamster cells

1971 • 17 citations

Temperature sensitive cells in the study of SV40 lysis versus SV40 transformation

1973 • 13 citations

A temperature-sensitive mutation in Escherichia coli transfer RNA

1972 • 11 citations

Isolation of temperature-sensitive mutants from murine leukemic cells (L5178Y)

1974 • 10 citations

A temperature-sensitive auxotropic variant of Chinese hamster ovary cells

1975 • 7 citations

Imperfect complementation in human-hamster somatic cell hybrids

1976 • 7 citations

The role of 5-S RNA in temperature-sensitive ribosomal RNA maturation

1975 • 4 citations