Differential Susceptibility of Human Apolipoprotein E Isoforms to Oxidation and Consequences on their Interaction with Phospholipids

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

1996 • 1,734 citations

Methionine residues as endogenous antioxidants in proteins

1996 • 1,005 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Apolipoprotein E: an important gene and protein to follow in laboratory medicine

1995 • 352 citations

Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.

1993 • 345 citations

Chloramines as intermediates of oxidation reaction of amino acids by myeloperoxidase

1971 • 272 citations

Fibrillogenesis in Alzheimer's disease of amyloid β peptides and apolipoprotein E

1995 • 255 citations

Choline metabolism as a basis for the selective vulnerability of cholinergic neurons

1992 • 244 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

Drug metabolizing enzymes in the brain and cerebral microvessels

1991 • 183 citations

Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia

1996 • 123 citations

Effect of oxidation on the properties of apolipoproteins A-I and A-II.

1988 • 120 citations

Immunochemical detection of oxidized proteins

1993 • 116 citations

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

1996 • 100 citations

Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation

1996 • 93 citations

Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain

1996 • 49 citations

Free radicals and disruption of neuronal ion homeostasis in AD: A role for amyloid β-peptide?

1995 • 44 citations

A Review of Plasma Apolipoprotein A-I Interactions with Phosphatidylcholines

1984 • 25 citations

Malondialdehyde adducts to, and fragmentation of, apolipoprotein B from human plasma

1993 • 20 citations

Characterization of Three Human Apolipoprotein E Isoforms (E2, E3 and E4) Expressed in Escherichia coli

1997 • 10 citations