Functional consequences of perceived interleukin deficiencies? Analysis employing NZB x C58 recombinant inbred mice.

T‐Cell Growth Factor

1980 • 917 citations

The Biochemistry, Biology, and Role of Interleukin 2 in the Induction of Cytotoxic T Cell and Antibody-Forming B Cell Responses

1982 • 524 citations

Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).

1983 • 453 citations

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

1982 • 421 citations

Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.

1978 • 379 citations

Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

1981 • 334 citations

Increased Spontaneous Polyclonal Activation of B Lymphocytes in Mice with Spontaneous Autoimmune Disease

1978 • 305 citations

Production of lymphocyte-activating factor (Interleukin 1) by macrophages activated with colony-stimulating factors.

1980 • 272 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

Interleukin 2 deficiency is a common feature of autoimmune mice.

1981 • 198 citations

Identification of a specific interleukin 1 inhibitor in the urine of febrile patients.

1984 • 187 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

1982 • 159 citations

Syngeneic Mixed Lymphocyte Reaction in Mice: Strain Distribution, Kinetics, Participating Cells, and Absence in NZB Mice

1978 • 126 citations

Lymphokines: their role in lymphocyte responses. Properties of interleukin 1.

1982 • 113 citations

Physicochemical Characterization of Lymphocyte-Activating Factor (LAF)

1979 • 99 citations

Decline, in aging mice, of the anti‐2, 4, 6‐trinitrophenyl (TNP) cytotoxic T cell response attributable to loss of Lyt‐2⁻, interleukin 2‐producing helper cell function

1981 • 91 citations

Significance of Self‐Recognition and Interleukin‐2 for Immunoregulation, Autoimmunity and Cancer

1982 • 87 citations

Relationship between IL 2 synthesis and the proliferative response to PHA in different primary immunodeficiencies.

1982 • 82 citations

The association of the HL-A antigens with diseases

1974 • 79 citations

T cell abnormalities in NZB mice occur independently of autoantibody production.

1981 • 77 citations

Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.

1982 • 69 citations

Independent segregation of NZB immune abnormalities in NZB X C58 recombinant inbred mice

1982 • 49 citations

Interleukin 1 production by a human acute monocytic leukemia cell line

1983 • 45 citations

Decreased Syngeneic Mixed Lymphocyte Reaction in Autoimmune Susceptible Mice

1982 • 42 citations

Histocompatibility Systems, Immune Response, and Disease in Man

1974 • 36 citations

Helper cells in the autologous mixed lymphocyte reaction. III. Production of helper factor(s) distinct from interleukin 2.

1982 • 31 citations

Helper cells in the autologous mixed lymphocyte reaction. I. Generation of cytotoxic T cells recognizing modified self H-2.

1981 • 18 citations

Cytokine production by NZB, C58, and NZB × C58 recombinant inbred mice

1984 • 16 citations

An ELISA assay for murine amyloid a and serum amyloid a utilizing monoclonal antibodies

1982 • 11 citations

Helper cells in the autologous mixed lymphocyte reaction. II. Age-related helper defect for generation of TNP-self cytotoxic cells in NZB mice.

1982 • 11 citations