Biological Effects of Lymphocyte and Macrophage-Derived Mitogenic “Amplication” Factors

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 921 citations

Manual of Clinical Immunology

1977 • 772 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 742 citations

“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation

1969 • 575 citations

Prostaglandin-Producing Suppressor Cells in Hodgkin's Disease

1977 • 552 citations

Absolute Macrophage Dependency of T Lymphocyte Activation by Mitogens

1976 • 425 citations

Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.

1978 • 379 citations

Identification of Macrophage-Like Characteristics in a Cultured Murine Tumor Line

1975 • 374 citations

THE EFFECTS OF MERCAPTOETHANOL AND OF PERITONEAL MACROPHAGES ON THE ANTIBODY-FORMING CAPACITY OF NONADHERENT MOUSE SPLEEN CELLS IN VITRO

1972 • 267 citations

Characterization of Lymphocyte-Activating Factor (LAF) Produced by the Macrophage Cell Line, P388D1

1978 • 237 citations

STUDIES ON MEDIATOR PRODUCTION BY HIGHLY PURIFIED HUMAN T AND B LYMPHOCYTES

1974 • 234 citations

The modulation of lymphocyte functions by molecules secreted by macrophages. I. Description and partial biochemical analysis.

1975 • 229 citations

Mitogens in Immunobiology

1977 • 217 citations

A Factor stimulating DNA Synthesis derived from the Medium of Leucocyte Cultures

1965 • 193 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1970 • 186 citations

Bidirectional Amplification of Macrophage-Lymphocyte Interactions: Enhanced Lymphocyte Activation Factor Production by Activated Adherent Mouse Peritoneal Cells

1977 • 184 citations

A Lymphocyte-stimulating Factor produced in vitro

1965 • 172 citations

Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS.

1978 • 172 citations

Immune Response Restoration with Macrophage Culture Supernatants

1971 • 155 citations

Detection, isolation, and functional characterization of two human T-cell subclasses bearing unique differentiation antigens.

1977 • 154 citations

Purification and Properties of Human Lymphocyte Activating Factor (LAF)

1977 • 154 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

Lymphocyte reactivity in vitro

1970 • 142 citations

Lymphokines in the rheumatoid joint

1975 • 140 citations

Phorbol myristic acetate stimulates LAF production by the macrophage cell line, P388D

1978 • 134 citations

Potentiation of Cultured Mouse Thymocyte Responses by Factors Released by Peripheral Leucocytes

1971 • 124 citations

Potentiation of the T lymphocyte response to mitogens

1974 • 122 citations

Macrophage Sensitivity to Endotoxin: Genetic Control by a Single Codominant Gene

1978 • 122 citations

INTERACTION OF HUMAN THYMUS-DERIVED AND NON-THYMUS-DERIVED LYMPHOCYTES IN VITRO

1973 • 122 citations

The role of macrophages in the generation of T helper cells. III. Influence of macrophage‐derived factors in helper cell induction

1975 • 122 citations

Lymphocyte Mitogenic Factor in Man

1969 • 117 citations

The modulation of lymphocyte functions by molecules secreted by macrophages. II. Conditions leading to increased secretion.

1976 • 117 citations

Lymphocyte Stimulation: Transfer of Cellular Hypersensitivity to Antigen in vitro

1969 • 108 citations

Signals Regulating in vitro Activation of Lymphocytes

2015 • 107 citations

Thymic Maturation in Vitro by a Secretory Product from Macrophages

1977 • 93 citations

Induction of lymphokine production by EAC and of blastogenesis by soluble mitogens during human B-cell activation

1974 • 92 citations

Enhancement of DNA Synthesis and cAMP Content of Mouse Thymocytes by Mediator(s) Derived from Adherent Cells

1976 • 91 citations

Regulation of immunity and inflammation by mediators from macrophages.

1976 • 89 citations

Synthesis and Secretion of a Mitogenic Protein by Macrophages: Description of a Superinduction Phenomenon

1977 • 87 citations

Characterization of Lymphocyte-Activating Factor (LAF) Produced by a Macrophage Cell Line, P388D1

1978 • 85 citations

On the Mode of Action of BCG

1973 • 82 citations

Secretion of mediators following T lymphocyte-macrophage interaction is regulated by the major histocompatibility complex.

1977 • 79 citations

Potentiation of in vitro Lymphocyte Reactivity

1970 • 73 citations

Further studies on the thymocyte stimulating factor

1976 • 67 citations

The role of fetal calf serum in the primary immune response in vitro.

1977 • 67 citations

The specificity of T-cell helper factor in man

1977 • 67 citations

Human lymphocyte mitogenic factor: Synthesis by sensitized thymus-derived lymphocytes, dependence of expression on the presence of antigen

1974 • 66 citations

Association of a Low Molecular Weight Helper Factor(s) with Thymocyte Proliferative Activity

1977 • 65 citations

Phytohemagglutinin-induced proliferation of guinea pig thymus-derived lymphocytes. II. Accessory cell function.

1976 • 65 citations

Stimulation of monocyte cGMP by leukocyte dialysates. An antigen-independent property of dialyzable transfer factor.

1975 • 59 citations

STIMULUS-RESPONSE IN THE MIXED LYMPHOCYTE REACTION

1973 • 59 citations

Signals Regulating <i>in vitro</i> Activation of Lymphocytes (Part 1 of 3)

1975 • 54 citations

Physiological regulation of antigen binding to T cells: role of a soluble macrophage factor and of interferon.

1977 • 52 citations

Interaction between lymphocytes and inflammatory exudate cells. I. Enhacement of thymocyte response to PHA by product(s) of polymorphonuclear leukocytes and macrophages.

1975 • 51 citations

Activation of lymphoid cells by BCG in vitro

1975 • 48 citations

Stimulation of the release of a B cell-activating factor from human monocytes

1976 • 47 citations

Interaction between lymphocytes and inflammatory exudate cells. II. A proteolytic enzyme released by PMN as a possible mediator for enhancement of thymocyte response.

1976 • 44 citations

Studies on Lymphokines: The Production of Antibody to Guinea Pig Lymphotoxin and its Use to Distinguish Lymphotoxin from Migration Inhibitory Factor and Mitogenic Factor

1975 • 43 citations

The production of lymphocyte mitogenic factor and migration-inhibition factor by antigen-stimulated lymphocytes of subjects with grass pollen allergy.

1971 • 39 citations

Mitogenic Factors Produced by Lymphocyte Activation: Effect on T- and B-Cells

1972 • 35 citations

Antibodies to guinea pig lymphokines. IV. Suppression of the mixed leukocyte culture reaction by anti-lymphokine globulin.

1976 • 34 citations

The effect of irradiation on the release of lymphocyte-activating factor (LAF)

1973 • 32 citations

Characterization of Mouse Cells Releasing or Responding to Mitogenic Factor Induced by Phytomitogens in Vitro

1975 • 32 citations

Identification and Partial Purification of Two Synergistically Acting Helper Mediators in Human Mixed Leukocyte Culture Supernatants

1977 • 32 citations

Heterogeneity of Blastogenic Factors Produced in Vitro by Antigenically Stimulated and Unstimulated Leukocytes

1970 • 31 citations

Interaction Between Lymphocytes and Inflammatory Exudate Cells

1975 • 30 citations

Enhancement of Mouse Thymus Cells Response to Periodate Treatment by a Soluble Factor

1972 • 30 citations

Role of B lymphocytes in cell-mediated immunity. I. Requirement for T cells or T-cell products for antigen-induced B-cell activation.

1976 • 29 citations

Products of Interaction of Antigen-Sensitized Leukocytes and Antigen: Further Characterization of the Mitogenic Factor

1970 • 27 citations

Characterization of Guinea Pig Mitogenic Factor

1975 • 27 citations

The Molecular Dimensions of Mitogenic Factor from Guinea Pig Lymph Node Cells

1975 • 26 citations

Interaction Between Lymphocytes and Inflammatory Exudate Cells

1976 • 24 citations

Phytohemagglutinin-Induced Proliferation of Guinea Pig Thymus-Derived Lymphocytes

1976 • 24 citations

Potentiation of the T lymphocyte response to mitogens

1977 • 24 citations

Germinal centre proliferation in response to mitogenic lymphokines.

1974 • 24 citations

The dissociation of adjuvant properties of mycobacterial components from mitogenicity, and from the ability to induce the release of mediators from macrophages.

1976 • 23 citations

Functional activation of immune lymphocytes by antigenic stimulation in cell-mediated immunity II. Analysis of the macrophage-replacing activity of the LPS-stimulated macrophage culture supernatant in the antigenic activation of purified immune lymphocytes

1976 • 21 citations

Two distinct lumphocyte-stimulating soluble factors (LAF) released from murine peritoneal cells. I. The cellular source and the effect of cGMP on their release.

1976 • 20 citations

Separation of Lymphocyte Mitogen from Lymphotoxin and Experiments on the Production of Lymphotoxin by Lymphoid Cells Stimulated with the Partially Purified Mitogen: A Possible Amplification Mechanism of Cellular Immunity and Allergy

1976 • 20 citations

Mechanisms of action of 'lymphocyte activating factor' (LAF) I. Association of lymphocyte activating factor action with early DNA synthesis in PHA-stimulated lymphocytes.

1977 • 20 citations

Anti-lymphokine antibody. II. Specificity of biological activity.

1976 • 20 citations

Immunocytology of cultured IgM-forming cells of mouse

1974 • 19 citations

Antibodies to Guinea Pig Lymphokines

1976 • 19 citations

MLC stimulatory capacity and production of blastogenic factor in patients with chronic lymphatic leukemia and Hodgkin's disease

1975 • 18 citations

Anti-Lymphokine Antibody

1976 • 18 citations

Mitogenic factor from inbred guinea pigs

1973 • 14 citations

An assay for human lymphocyte mitogenic factor: B-lymphocyte stimulation by a T-lymphocyte product

1978 • 14 citations

Mitogenic factor from inbred guinea pigs

1973 • 12 citations

SOLUBLE FACTORS PRODUCED BY LYMPHOCYTES *

1974 • 12 citations

Some effects of thymocyte-stimulating factor

1977 • 10 citations

Characterization of lymphocyte activating factor from mouse tumor cell lines and human leukocytes

1976 • 8 citations

Thymocyte-stimulating factor from peripheral blood cells

1977 • 8 citations

Evidence of Different Cell Populations in the Mouse Thymus Releasing and Responding to Mitogenic Factor

1975 • 8 citations

Production and Specificity of a Blastogenic Factor in Mixed Leucocyte Cultures from Twin Sisters

1970 • 7 citations

Blastogenesis of autologous, allogeneic, and syngeneic (identical twins) lymphocytes in response to lymphokines generated in dinitrochlorobenzene-sensitive human leukocyte cultures.

1974 • 6 citations

Lymphocyte transforming factor in sarcoidosis

1974 • 5 citations

Blastogenesis of Autologous, Allogeneic, and Syngeneic (Identical Twins) Lymphocytes in Response to Lymphokines Generated in Dinitrochlorobenzene-Sensitive Human Leukocyte Cultures

1974 • 5 citations

A microplate culture method for assay of guinea pig mitogenic factor

1975 • 5 citations

Effects of inhibitors of DNA and protein syntheses on mitogenic factor production by PPD-stimulated guinea pig lymphocytes.

1976 • 4 citations

Impaired production of T-lymphocyte mitogens in pediatric malignant disease

1978 • 3 citations