Role of Growth Factors in Gastroduodenal Protection and Healing of Peptic Ulcers

POLYAMINES

1984 • 2,996 citations

Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal

1962 • 2,192 citations

Physiology of the Gastrointestinal Tract.

1987 • 1,948 citations

Cytoprotection by prostaglandins

1979 • 1,076 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

The Primary Structure of Epidermal Growth Factor

1972 • 533 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Regulation of gastrointestinal mucosal growth

1988 • 330 citations

The turnover and shedding of epithelial cells: Part I The turnover in the gastro-intestinal tract

1961 • 285 citations

Cell Proliferation and Migration in the Stomach, Duodenum, and Rectum of Man: Radioautographic Studies

1964 • 283 citations

Effect of polyamines on acidified ethanol-induced gastric lesions in rats.

1983 • 283 citations

Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats

1988 • 274 citations

Liver Investigation in 149 Asymptomatic Patients with Moderately Elevated Activities of Serum: Aminotransferases

1986 • 266 citations

Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Morphologic and physiologic characteristics.

1982 • 236 citations

Zollinger–Ellison Syndrome

1987 • 234 citations

THE TWO-COMPONENT MUCOUS BARRIER

1954 • 222 citations

Role of submandibular saliva and epidermal growth factor in gastric cytoprotection

1984 • 217 citations

Immunohistochemical localization of epidermal growth factor in rat and man

1986 • 212 citations

Regulation of Gastrointestinal Growth

1984 • 210 citations

Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride

1982 • 207 citations

Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.

1982 • 203 citations

Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands.

1978 • 198 citations

Epidermal Growth Factor (Urogastrone) in Human Fluids: Size Heterogeneity*

1979 • 183 citations

Gastric cytoprotection by epidermal growth factor. Role of endogenous prostaglandins and DNA synthesis.

1981 • 183 citations

Delayed Healing of Acetic Acid-Induced Gastric Ulcers in Rats by Indomethacin

1989 • 166 citations

Distribution and release of epidermal growth factor in man.

1989 • 161 citations

Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor

1984 • 155 citations

Stimulating Effect of Gastrin on Cell Proliferation Kinetics in Canine Fundic Mucosa

1972 • 155 citations

Gastric cytoprotection by epidermal growth factor

1981 • 148 citations

Effect of Growth Hormone Release-Inhibiting Hormone on Gastric Secretion, Mucosal Blood Flow, and Serum Gastrin

1976 • 146 citations

Effects of Intraluminal Epidermal Growth Factor on Mucosal Proliferation in the Small Intestine of Adult Rats

1986 • 145 citations

Effect of Aspirin and Related Compounds on the Fine Structure of Mouse Gastric Mucosa

1971 • 140 citations

Epidermal Growth Factor Stimulates Ornithine Decarboxylase Activity in the Digestive Tract of Mouse

1978 • 138 citations

Effect of sialoadenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats.

1986 • 137 citations

The effect of epidermal growth factor on wound healing in mice

1982 • 137 citations

Control of a Cell Surface Major Glycoprotein by Epidermal Growth Factor

1977 • 136 citations

Proposed model of major sequential biochemical events of a trophic response

1976 • 135 citations

Effect of salivary glands on wound contraction in mice

1979 • 135 citations

The effect of epidermal growth factor (EGF) on cell proliferation of the gastrointestinal mucosa in rodents

1982 • 130 citations

Distribution and characterisation of immunoreactive somatostatin in human gastrointestinal tract

1983 • 120 citations

Enhanced synthesis and extracellular accumulation of hyaluronic acid during stimulation of quiescent human fibroblasts by mouse epidermal growth factor

1976 • 120 citations

Gastric Mucosal Barrier

1971 • 119 citations

Stimulation of rat oxyntic gland mucosal growth by epidermal growth factor

1980 • 117 citations

Renal origin of rat urinary epidermal growth factor

1984 • 116 citations

Gastric Hydrogen Ion Secretion.

1977 • 110 citations

Influence of Long-Term 16,16-Dimethyl Prostaglandin E2 Treatment on the Rat Gastrointestinal Mucosa

1983 • 101 citations

Epidermal Growth Factor Inhibits Cysteamine-Induced Duodenal Ulcers

1983 • 100 citations

Effect of urogastrone on gastric secretion and plasma gastrin levels in normal subjects.

1975 • 100 citations

Effect of Somatostatin on Normal and Gastric-Stimulated Cell Proliferation in the Gastric and Intestinal Mucosae of the Rat

1979 • 98 citations

The identification of urogastrone in serum, saliva, and gastric juice

1979 • 98 citations

Changes in the Fine Structure of Mouse Gastric Epithelium Produced by Ethanol and Urea

1974 • 96 citations

Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.

1981 • 96 citations

The Gastric Mucosal Barrier

1972 • 89 citations

Oral administration of synthetic human urogastrone promotes healing of chronic duodenal ulcers in rats

1986 • 89 citations

Pentagastrin protects against stress ulceration in rats

1979 • 88 citations

Somatostatin and the stomach: Exocrine and endocrine aspects

1978 • 86 citations

Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers

1985 • 84 citations

Rapid repair of injured gastric mucosa.

1984 • 82 citations

Cytoprotection-organoprotection by somatostatin: gastric and hepatic lesions

1982 • 81 citations

Epidermal Growth Factor: Mechanisms of Action

1982 • 81 citations

Effects of epidermal growth factor on gastrointestinal secretions

1984 • 80 citations

Prostaglandins Mediate Inhibition of Gastric Acid Secretion by Somatostatin in the Rat

1983 • 80 citations

Cell population kinetics of zymogen and parietal cells in the stomach of mice

1972 • 79 citations

Adrenergic effects on secretion of epidermal growth factor from Brunner's glands.

1985 • 77 citations

Adrenergic effects on exocrine secretion of rat submandibular epidermal growth factor.

1984 • 75 citations

A functional model for extracellular gastric mucus in the rat

1984 • 71 citations

Pharmacological studies of somatostatin and somatostatin-analogues: Therapeutic advances and perspectives

1987 • 65 citations

Influence of Prostaglandins, Omeprazole, and Indomethacin on Healing of Experimental Gastric Ulcers in the Rat

1988 • 63 citations

EFFECT OF POLYAMINES ON ACIDIFIED ETHANOL-INDUCED GASTRIC LESIONS IN RATS

1983 • 60 citations

Plasma somatostatin 28 increases in response to feeding in man.

1983 • 60 citations

Patterns of Recurrence in Relation to Therapeutic Strategy in Gastric Cancer

1987 • 55 citations

Epidermal growth factor‐like material in rat submandibular gland

1979 • 54 citations

Treatment of Duodenal Ulcer with Secretin: A Speculative Proposal

1966 • 54 citations

Influence of oral 15(R)-15-methyl prostaglandin E2 on human gastric mucosa

1986 • 52 citations

Cytoprotective and Ulcer Healing Properties of Prostaglandin E<sub>2</sub>, Colloidal Bismuth and Sucralfate in Rats

1987 • 52 citations

Characterization and repartition of epidermal growth factor-urogastrone receptors in gastric glands isolated from young and adult guinea pigs

1984 • 52 citations

Somatostatin in epithelial cells of intestinal mucosa is present primarily as somatostatin 28

1984 • 51 citations

Epidermal growth factor in blood

1986 • 51 citations

Somatostatin: Basic And Clinical Status

2013 • 51 citations

Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats.

1988 • 50 citations

Does Epidermal Growth Factor Play a Role in the Action of Sucralfate?

1987 • 50 citations

Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

1988 • 50 citations

Advances in drug therapy of gastrointestinal ulceration

1990 • 49 citations

The Distribution and Characterization of Somatostatin-Like Immunoreactivity in Epithelial Cells, Submucosa, and Muscle of the Rat Stomach and Intestine*

1981 • 49 citations

Failure of secretin release in patients with duodenal ulcer.

1975 • 47 citations

Immunoreactive somatostatin and vasoactive intestinal peptide in the digestive tract of cats

1980 • 46 citations

Exocrine and endocrine secretion of renin and epidermal growth factor from the mouse submandibular glands

1984 • 45 citations

Interaction of Growth Hormone-Releasing Factor and Somatostatin on Ulcer Healing and Mucosal Growth in Rats: Role of Gastrin and Epidermal Growth Factor

1988 • 45 citations

Effect of Epidermal Growth Factor on Collagen Formation in Liver-Derived Epithelial Clone Cells

1982 • 44 citations

Some Physicochemical Properties of Ribonucleoprotein from Rat Liver Microsomes

1962 • 42 citations

Aggressive behaviour in mice provokes a marked increase in both plasma epidermal growth factor and renin

1981 • 41 citations

Inhibition of acid formation by epidermal growth factor in the isolated rabbit gastric glands.

1986 • 40 citations

Cytoprotective Effect of Pentagastrin and Epidermal Growth Factor on Stress Ulcer Formation

1985 • 40 citations

Somatostatin depletion by cysteamine: mechanism and implication for duodenal ulceration.

1985 • 39 citations

Salivary immunoreactive human epidermal growth factor (IR-hEGF) in patients with peptic ulcer disease.

1987 • 39 citations

Effect of Hypophysectomy and Growth Hormone on Serum and Antral Gastrin Levels in the Rat

1976 • 39 citations

Experimental and Clinical Studies on Epidermal Growth Factor for Gastric Mucosal Protection and Healing of Gastric Ulcers

1988 • 38 citations

Influence of Desalivation on Acid Secretory Output and Gastric Mucosal Integrity in the Rat

1981 • 38 citations

Long-Acting Somatostatin (SMS 201-995) in the Management of Zollinger-Ellison Syndrome

1988 • 37 citations

Histological Changes in the Gastric Mucosa During Digestion and their Relationship to Mucosal Growth

1953 • 36 citations

Gastrointestinal Hormones

1988 • 36 citations

Somatostatin prevents cysteamine-induced duodenal ulcer

1977 • 34 citations

Release and Action of Epidermal Growth Factor on Gastric Secretion in Humans

1989 • 33 citations

Dose-dependent effects of linear and cyclic somatostatin on ethanol-induced gastric erosions: the role of mast cells and increased vascular permeability in the rat

1986 • 32 citations

Effect of urogastrone on gastric secretion and serum gastrin concentration in patients with duodenal ulceration.

1982 • 31 citations

Effect of Cell Proliferation on Healing of Gastric and Duodenal Ulcers in Rats

1986 • 31 citations

Epidermal Growth Factor Content of Submandibular Glands is Increased in Rats with Experimentally Induced Gastric Lesions

1988 • 30 citations

Effect of somatostatin on meal-induced gastric secretion in duodenal ulcer patients

1977 • 30 citations

The Role of Somatostatin and a Long-Acting Analogue, SMS 201-995, in Acute Bleeding due to Peptic Ulceration

1986 • 29 citations

Changes in protein and nucleic acid synthesis in rat gastric mucosa after pentagastrin.

1977 • 27 citations

Trophic actions of E2 prostaglandins in the rat gastrointestinal mucosa

1985 • 26 citations

The Role of Smoking in Peptic Ulcer Disease

1988 • 26 citations

Decreased Incidence of Restraint-Stress Induced Gastric Erosions in Rats Treated with Bovine Growth Hormone

1970 • 25 citations

Effect of Somatostatin on Gastrointestinal Secretions and Peptic Ulcer Production in Cats

1977 • 25 citations

Influence of oral 15(R)-15-methyl prostaglandin E2 on human gastric mucosa

1986 • 24 citations

Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat

1985 • 23 citations

Absorption of epidermal growth factor and insulin in rabbit renal proximal tubules

1989 • 23 citations

Relationship between ornithine decarboxylase activity and gastric damage

1987 • 21 citations

Gastric secretion and ulcer formation after hypophysectomy and administration of somatotrophic hormone

1966 • 21 citations

Influence of Stress on Epithelial Cell Proliferation in the Gut Mucosa of Rats

1988 • 21 citations

Inhibition of stress ulcer formation with somatostatin in rats

1976 • 19 citations

Is the beneficial effect of urine extracts on mann-williamson ulcers due to the gastric secretory depressant in urine?

1942 • 16 citations

Cysteamine-induced reduction in gastrointestinal somatostatin: evidence for a region-specific loss in immunoreactivity

1988 • 13 citations

Studies on shrew (Suncus murinus) epidermal growth factor

1986 • 13 citations

Effect of cell proliferation and loss on aspirin-induced gastric damage in the rat

1982 • 13 citations

Effect of somatostatin on the growth of gastrointestinal mucosa and pancreas in rats. Role of endogenous gastrin.

1987 • 12 citations

Epidermal growth factor in plasma, serum and urine before and after prolonged exercise

1988 • 11 citations

Towards Clean Air

1960 • 9 citations

Gastric mucosal protection by somatostatins.

1986 • 8 citations

Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats

1973 • 4 citations

Somatostatin, Clearance and Inhibition of Gastric Acid Secretion in Duodenal Ulcer Patients

1987 • 1 citations