Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

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2003 • 10,877 citations

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2003 • 6,672 citations

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2006 • 4,789 citations

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2011 • 3,631 citations

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2020 • 2,167 citations

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2015 • 1,409 citations

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2012 • 760 citations

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2016 • 626 citations

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2019 • 590 citations

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2017 • 527 citations

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2006 • 497 citations

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2016 • 483 citations

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2018 • 451 citations

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2007 • 435 citations

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2019 • 391 citations

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2014 • 388 citations

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2005 • 305 citations

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2015 • 292 citations

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2015 • 272 citations

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2020 • 248 citations

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2016 • 224 citations

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2017 • 200 citations

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2019 • 191 citations

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2014 • 186 citations

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2017 • 185 citations

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2019 • 182 citations

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2011 • 181 citations

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2017 • 164 citations

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2016 • 155 citations

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2015 • 142 citations

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2002 • 134 citations

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2013 • 133 citations

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2019 • 132 citations

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2013 • 127 citations

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2020 • 126 citations

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2012 • 125 citations

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2018 • 107 citations

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2012 • 105 citations

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2016 • 95 citations

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2013 • 91 citations

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2014 • 88 citations

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2009 • 83 citations

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2016 • 82 citations

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2016 • 78 citations

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2002 • 76 citations

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2014 • 74 citations

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2014 • 69 citations

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2013 • 67 citations

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2016 • 66 citations

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2018 • 60 citations

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2015 • 58 citations

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2019 • 56 citations

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2017 • 55 citations

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2009 • 55 citations

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2019 • 51 citations

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2012 • 50 citations

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2015 • 49 citations

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2010 • 47 citations

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2011 • 44 citations

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2006 • 41 citations

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2018 • 30 citations

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2006 • 28 citations

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2013 • 27 citations

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2004 • 27 citations

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2017 • 26 citations

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2017 • 25 citations

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2017 • 20 citations

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1992 • 17 citations

The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection

2017 • 16 citations

Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer’s Disease

2020 • 14 citations

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2008 • 11 citations