Platinum Analogues: Criteria for Selection

Platinum Compounds: a New Class of Potent Antitumour Agents

1969 • 3,785 citations

Cisplatin : current status and new developments

1980 • 746 citations

High dose Cis-platinum diammine dichloride.Amelioration of renal toxicity by mannitol diuresis

1977 • 622 citations

Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes

1973 • 561 citations

Platinum nephrotoxicity

1978 • 442 citations

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).

1973 • 430 citations

Cis-diamminedichloroplatinum (II)

1977 • 424 citations

The Mechanism of Action of Antitumor Platinum Compounds

1979 • 408 citations

cis-Dichlorodiammineplatinum(II): combination chemotherapy and cross-resistance studies with tumors of mice.

1979 • 405 citations

DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity.

1979 • 402 citations

Cisplatin (cis-diamminedichloroplatinum II)

1979 • 397 citations

Platinum coordination complexes in cancer chemotherapy

1973 • 379 citations

The successful regression of large solid sarcoma 180 tumors by platinum compounds.

1970 • 372 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

The renal pathology in clinical trials of Cis-platinum (II) diamminedichloride

1977 • 345 citations

Long term effect of Cis-Diamminedichloride platinum (CDDP) on renal function and structure in man

1978 • 306 citations

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

1979 • 244 citations

New platinum complexes with anti-tumour activity

1972 • 238 citations

Platinum Complexes for the Treatment of Cancer

1978 • 213 citations

DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.

1981 • 213 citations

Distribution and disposition of platinum following intravenous administration of cis-diamminedichloroplatinum(II) (NSC 119875) to dogs.

1976 • 205 citations

Interactions of hyperthermia and chemotherapy in animals.

1979 • 204 citations

Kinetics of cis‐dichlorodiammineplatinum

1979 • 192 citations

Phase II study of cis-dichlorodiammineplatinum(II) (NSC-119875) in advanced adenocarcinoma of the ovary.

1976 • 179 citations

Improved Chemotherapy in Disseminated Testicular Cancer

1977 • 176 citations

The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals

1978 • 173 citations

Anti-tumour platinum complexes : relationships between chemical properties and activity

1978 • 173 citations

Modifications of the DNA secondary structure upon platinum binding: a proposed model

1978 • 170 citations

Studies of cross-resistance, synergistic combinations and blocking of activity of platinum derivatives

1978 • 160 citations

Mechanism of Substitution Reactions of Complex Ions. XVII.¹ Rates of Reaction of Some Platinum(II) and Palladium(II) Complexes with Pyridine²

1960 • 157 citations

The nephrotoxic effects of cis-diammine-dichloroplatinum (II) (NSC-119875) in male F344 rats

1976 • 152 citations

The chemotherapy of urologic cancer

1975 • 151 citations

Structure and activity relationships of platinum complexes with anti-tumour activity

1975 • 150 citations

Cis-dichlorodiammineplatinum(II) in advanced bladder cancer.

1976 • 142 citations

Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig

1975 • 138 citations

Diamminodichloroplatinum in the Chemotherapy of Testicular Tumors

1974 • 135 citations

cis-Dichlorodiammineplatinum(II) (NSC-119 875): Preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice

1973 • 131 citations

Clinical studies of Platinum Coordination compounds in the treatment of various malignant diseases.

1975 • 127 citations

Therapeutic Synergism of Hyperthermia-cis-Platinum in a Mouse Tumor Model<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1980 • 122 citations

Kinetics of formation and disappearance of a DNA cross-linking effect in mouse leukemia L1210 cells treated with cis- and trans-diamminedichloroplatinum(II).

1978 • 115 citations

Mutagenicity, cytotoxicity and DNA crosslinking in V79 Chinese hamster cells treated with cis- and trans-Pt(II) diamminedichloride

1979 • 112 citations

Acute toxicologic and pathologic effects of cis-diamminedichloroplatinum (NSC-119875) in the male rat.

1971 • 106 citations

Review of the current clinical status of platinum coordination complexes in cancer chemotherapy.

1975 • 104 citations

Nephrotoxicity of cis-dichlorodiammineplatinum(II).

1979 • 98 citations

Disposition and distribution of platinum following parenteral administration of cis-dichlorodiammineplatinum(II) to animals.

1979 • 95 citations

Cis-dichlorodiammineplatinum (II) (NSC-119875): hearing loss and other toxic effects in rhesus monkeys.

1975 • 95 citations

Cis-platinum: a new anticancer agent.

1979 • 94 citations

Platinate toxicity: past, present, and prospects.

1979 • 91 citations

Rationale for development of platinum analogs.

1979 • 86 citations

Distribution and retention of the antitumor agent 195mPt-cis-dichlorodiammine platinum (II) in man.

1974 • 85 citations

The antitumor agent cis-Pt(NH 3 ) 2 Cl 2 : distribution studies and dose calculations for 193m Pt and 195m Pt.

1973 • 84 citations

Preparation and metabolism of a cisplatin/serum protein complex

1980 • 82 citations

Platinum complexes: A new class of antineoplastic agents

1976 • 82 citations

Plasma levels and urinary excretion of filterable platinum species following bolus injection and iv infusion of cis-dichlorodiammineplatinum(II) in man.

1978 • 79 citations

Renal handling of cis-diamminedichloroplatinum(II).

1980 • 75 citations

cis-Dichlorodiammineplatinum(II) for the treatment of advanced ovarian cancer.

1979 • 73 citations

Measurement of free-circulating cis-dichlorodiammineplatinum(II) in plasma.

1977 • 71 citations

The Enhanced Therapeutic Effect of <i>cis</i>-Platinum (II) Diamminodichloride against L1210 Leukemia when Combined with Cyclophosphamide or 1,2-bis(3,5-Dioxopiperazine-1-yl)propane or Several other Antitumor Agents

1973 • 70 citations

Treatment of Advanced Bladder Cancer with Cis-Diamminedichloroplatinum (II NSC 119875): A Pilot Study

1978 • 69 citations

Treatment of genitourinary tumours with cis-dichlorodiammineplatinum(II): experience in 250 patients.

1979 • 69 citations

Effect of thiourea on survival and DNA cross-link formation in cells treated with platinum(II) complexes, L-phenylalanine mustard, and bis(2-chloroethyl)methylamine.

1979 • 66 citations

Synthesis and distribution of a radiolabeled antitumor agent: cis-diamminedichloroplatinum. II.

1972 • 66 citations

Cis-Diamminedichloride Platinum II in the Treatment of Abvanced Bladder Cancer

1980 • 66 citations

Inhibition of Dunning asc itic leukemia and Walker 256 carcinosarcoma with cis-diamminedichloroplatinum (NSC-119875).

1970 • 62 citations

A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs.

1974 • 58 citations

Selection of potential second generation platinum compounds

1978 • 57 citations

Platinum-DNA crosslinking: platinum antitumor drug interactions with native lambda bacteriophage DNA studied using a restriction endonuclease

1978 • 54 citations

Treatment of advanced ovarian cancer with cis=dichlorodiammineplatinum(II): poor-risk patients with intensive prior therapy.

1978 • 54 citations

Structure-activity relationships of the antitumor platinum coordination complexes.

1979 • 53 citations

Distribution of cis-platin in blood

1978 • 51 citations

Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis-diamminedichloroplatinum(II).

1981 • 50 citations

Single and combination chemotherapy for primary murine bladder cancer

1975 • 48 citations

Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro

1980 • 47 citations

1,2-Diaminocyclohexane Platinum Derivatives of Potential Clinical Value

1980 • 45 citations

Antileukemic Properties of Organoplatinum Complexes2

1976 • 45 citations

cis-Platinum (II) Diamminedichloride

1974 • 43 citations

"Platinum-pyrimidine blues" and related complexes: a new class of potent antitumor agents.

1975 • 41 citations

ANTITUMOR ACTIVITY OF PLATINUM (II) COMPLEXES OF 1, 2-DIAMINOCYCLOHEXANE ISOMERS

1980 • 39 citations

Combination chemotherapy with cis-dichlorodiammineplatinum(II) in disseminated testicular cancer.

1979 • 36 citations

Current dilemmas in the management of non-seminomatous germ cell tumors of the testis

1977 • 33 citations

Comparative nephrotoxicity of platinum cancer chemotherapeutic agents.

1976 • 32 citations

The pharmacokinetics of Cis-diamminodichloro-platinum (II) in animals and man : relation to treatment scheduling

1978 • 31 citations

Combination chemotherapy for ovarian carcinoma with cyclophosphamide, adriamycin, and cis-dichlorodiammineplatinum(II) after failure of initial chemotherapy.

1978 • 30 citations

Weekly administration of cis-diamminedichloroplatinum (II) without hydration or osmotic diuresis

1978 • 29 citations

Chemotherapy of advanced L1210 leukemia with platinum compounds in combination with other antitumor agents.

1977 • 29 citations

Combination Chemotherapy of L1210 Leukemia With Platinum Compounds and Cyclophosphamide Plus Other Selected Antineoplastic Agents 2

1976 • 28 citations

Antileukemia (L1210) activity and toxicity of cis-dichlorodiammineplatinum(II) analogs.

1979 • 26 citations

Bacterial, Viral and Tissue Culture Studies on Neutral Platinum Complexes

1974 • 25 citations

Drugs used in the treatment of cancer

1975 • 25 citations

Enhancement of the nuclear reactivity of alkylating agents by prednisolone.

1979 • 22 citations

Phase I clinical trial of combined therapy with vinblastine (NSC-49842), bleomycin (NSC-125066), and cisdichlorodiammineplatinum(II)( NSC-119875).

1976 • 20 citations

Nephrotoxic Potential of <italic>cis</italic>-Diamminedichloroplatinum and Four Analogs in Male Fischer 344 Rats<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 20 citations

Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.

1977 • 18 citations

Synergistic action of high-dose hydroxyurea when used with cyglophosphamide and certain new organoplatinum complexes in treatment of advanced L1210 leukemia

1978 • 18 citations

Clinical pharmacological and toxicological studies of Cis-diamminedichloroplatinum (II) by continuous intravenous infusion

1978 • 17 citations

CISPLATIN THERAPY OF OVARIAN CANCER

1980 • 15 citations

Untitled

1975 • 14 citations

Preparation and antitumor evaluation of water-soluble derivatives of dichloro(1,2-diaminocyclohexane)platinum(II).

1977 • 14 citations

NEW EXPERIMENTAL DRUG COMBINATIONS WITH POTENTIAL CLINICAL UTILITY

1975 • 13 citations

Antileukemic properties of dichloro(1,2-diaminocyclohexane)platinum(II).

1974 • 12 citations

Platinum analogs of clinical interest.

1979 • 11 citations

Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.

1979 • 11 citations

Preclinical and Phase I Studies of Malonatoplatinum

1980 • 10 citations

Platinum Complexes in Cancer Chemotherapy

2015 • 9 citations

Antitumor Action of Dichloro (4,5-dimethyl-o-phenylenediamine-N,N') platinum (II)

1973 • 8 citations

Anti-Tumour Effects of Platinum Complexes in Experimental Animals

1974 • 7 citations

Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia.

1979 • 7 citations

The Mechanisms of Organic Reactions

1954 • 5 citations

A new highly water soluble platinum antitumor compound (phic) with lower toxicity and higher therapeutic index than cisplatin. Abstr.

1981 • 2 citations

Deleted Work

1955 • 0 citations