Complement in diseases of the nervous system

Clinical Aspects of Immunology.

1969 • 1,563 citations

A Light and Electron Microscopic Study

1976 • 1,232 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

THE NEUROLOGICAL MANIFESTATIONS OF SYSTEMIC LUPUS ERYTHEMATOSUS

1968 • 831 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

The Clinical Aspects of Immunology.

1964 • 657 citations

Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.

1984 • 636 citations

Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

1973 • 633 citations

Complement Deficiency States and Infection

1984 • 527 citations

REDUCTION OF STRESS/ CATECHOLAMINE-INDUCED CARDIAC NECROSIS BY BETA1-SELECTIVE BLOCKADE

1987 • 449 citations

Central nervous system involvement in systemic lupus erythematosus: A review of neuropathologic findings in 57 cases, 1955–1977

1979 • 441 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

Macrophages, lymphocytes, and plasma cells in the perivascular compartment in chronic multiple sclerosis.

1978 • 419 citations

Activation of the classical complement pathway in brain tissue of Alzheimer patients

1989 • 385 citations

Complement Fixation on Cell Surfaces by 19 S and 7 S Antibodies

1965 • 336 citations

Immune complexes (IgG and C3) at the motor end-plate in myasthenia gravis: ultrastructural and light microscopic localization and electrophysiologic correlations.

1977 • 323 citations

Plasma-Cell Dyscrasia and Peripheral Neuropathy with a Monoclonal Antibody to Peripheral-Nerve Myelin

1980 • 310 citations

Complement activation in amyloid plaques in Alzheimer’s dementia

1988 • 289 citations

Hospitals in Switzerland.

1948 • 274 citations

Plasmapheresis and guillain‐barré syndrome: Analysis of prognostic factors and the effect of plasmapheresis

1988 • 273 citations

IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside.

1984 • 258 citations

Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods

1948 • 258 citations

Experimental demyelination of nerve induced by serum of patients with neuropathy and an anti‐MAG IgM M‐protein

1987 • 247 citations

Changes in Serum Complement Activity in Patients with Myasthenia Gravis.

1960 • 247 citations

Cerebrospinal fluid antibodies to neuronal cells: Association with neuropsychiatric manifestations of systemic lupus erythematosus

1981 • 245 citations

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1989 • 243 citations

Pathology of the Guillain-Barr� syndrome

1981 • 242 citations

Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis.

1978 • 239 citations

Ultrastructural Localization of the Terminal and Lytic Ninth Complement Component (C9) at the Motor End-plate in Myasthenia Gravis

1980 • 210 citations

Sjögren syndrome

1981 • 208 citations

IMMUNOCYTOCHEMICAL LOCALIZATION OF THE TERMINAL COMPLEMENT COMPLEX IN MULTIPLE SCLEROSIS

1989 • 182 citations

Complement-Mediated Demyelination in Patients with IgM Monoclonal Gammopathy and Polyneuropathy

1990 • 177 citations

Activated terminal complement in cerebrospinal fluid in Guillain-Barré syndrome and multiple sclerosis.

1986 • 163 citations

THE DIFFERENTIAL DIAGNOSIS OF NEUROLOGICAL DISEASES BY FRACTIONATING ELECTRO‐PHORETICALLY THE CSF γ‐GLOBULINS*

1960 • 163 citations

Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies.

1982 • 160 citations

THE ROLE OF COMPLEMENT IN THE PATHOGENESIS OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1989 • 156 citations

SERUM AND CEREBRAL SPINAL FLUID COMPLEMENT AND SERUM AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

1971 • 154 citations

Activation of terminal components of complement in patients with Guillain-Barré syndrome and other demyelinating neuropathies.

1987 • 148 citations

The epidemiology of Guillain-Barr� syndrome

1990 • 148 citations

COMPLEMENT DEFICIENCIES IN PATIENTS OVER TEN YEARS OLD WITH MENINGOCOCCAL DISEASE DUE TO UNCOMMON SEROGROUPS

1989 • 147 citations

The Membrane Attack Complex of Complement at the Endplate in Myasthenia Gravis^a

1987 • 139 citations

Properdin deficiency in a family with fulminant meningococcal infections.

1982 • 135 citations

[Advances in neurosurgery].

1993 • 135 citations

Functional Studies of Cultured Brain Tissues as Related to "Demyelinative Disorders"

1965 • 135 citations

Circulating Demyelinating Factors in Acute Idiopathic Polyneuropathy

1971 • 134 citations

The recovery of human polymorphonuclear leucocytes from sublytic complement attack is mediated by changes in intracellular free calcium

1985 • 133 citations

In vivo demyelinating activity of sera from patients with Guillain‐Barré syndrome

1982 • 131 citations

Immune complexes in serum and cerebrospinal fluid of multiple sclerosis patients and patients with other neurological diseases

2009 • 127 citations

Immune reactive C3d on the surface of myelin sheaths in neuropathy

1988 • 126 citations

The passive transfer of experimental allergic encephalomyelitis and neuritis with living lymphoid cells

1962 • 121 citations

Inhibition of acute passive transfer experimental autoimmune myasthenia gravis with Fab antibody to complement C6.

1989 • 115 citations

Clinical correlation with anti‐peripheral‐nerve myelin antibodies in Guillain‐Barré syndrome

1986 • 113 citations

Reactivity of Myasthenia Gravis Serum -Globulin with Skeletal Muscle and Thymus Demonstrated by Immunofluoirescence.

1964 • 108 citations

Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

1989 • 108 citations

Inherited deficiency of ninth component of complement: An increased risk of meningococcal meningitis

1989 • 107 citations

Experimental autoimmune myasthenia induced in monkeys by purified acetylcholine receptor

1975 • 106 citations

Activated complement components C3a and C4a in cerebrospinal fluid and plasma following subarachnoid hemorrhage

1989 • 103 citations

Normal rat serum cytotoxicity against syngeneic oligodendrocytes

1989 • 102 citations

Passively transferred experimental autoimmune myasthenia gravis

1979 • 93 citations

Immune complexes and complement activation following rupture of intracranial saccular aneurysms

1987 • 93 citations

Complete and partial deficiencies of complement factor D in a Dutch family.

1989 • 91 citations

Guillain‐barré syndrome

1987 • 88 citations

Antibody-mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation

1991 • 86 citations

Antibody-independent complement activation by myelin via the classical complement pathway.

1982 • 86 citations

Dysfunctional Properdin in a Dutch Family with Meningococcal Disease

1988 • 81 citations

Cellular damage and changes in biliary excretion in a liver lesion of cattle

1962 • 81 citations

TERMINAL COMPONENT OF COMPLEMENT (C9) IN CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS

1984 • 80 citations

The Fourth Component of Complement in the Cerebrospinal Fluid in Systemic Lupus Erythematosus

1973 • 79 citations

Plasmapheresis alleviates neuropathy accompanying IgM anti—Myelin‐Associated glycoprotein paraproteinemia

1988 • 79 citations

Complement‐fixing antiperipheral nerve myelin antibodies in patients with inflammatory polyneuritis and with polyneuropathy and paraproteinemia

1981 • 77 citations

Anti-peripheral nerve myelin antibodies in Guillain-Barre syndrome bind a neutral glycolipid of peripheral myelin and cross-react with Forssman antigen.

1989 • 76 citations

Multiple Sclerosis: Correlation between Immunoglobulin-G in Cerebrospinal Fluid and Brain

1966 • 75 citations

Central nervous system involvement in sle

1977 • 75 citations

Vesicular disruption of myelin simulated by exposure of nerve to calcium ionophore

1977 • 73 citations

Oligoclonal IgG and Free Light Chains in the Cerebrospinal Fluid of Patients with Multiple Sclerosis and Infectious Diseases of the Central Nervous System

1977 • 72 citations

A high incidence of C9 deficiency among healthy blood donors in Osaka, Japan

1989 • 71 citations

Cell-mediated immunity in idiopathic polyneuritis

1981 • 71 citations

Acute-Phase Proteins in Alzheimer’s Disease

1988 • 70 citations

Release of Leukotriene B₄ from Sublethally Injured Oligodendrocytes by Terminal Complement Complexes

1987 • 69 citations

Studies on demyelination in vitro: the requirement of membrane attack components of the complement system.

1983 • 68 citations

The role of C9 in complement-mediated killing of Neisseria.

1981 • 65 citations

Complement-activated oligodendroglia: A new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d

1990 • 65 citations

Peripheral demyelination and remyelination initiated by the calcium-selective ionophore ionomycin: In vivo observations

1988 • 65 citations

Evidence of an immunopathogenic basis for central nervous system disease in primary Sjögren's syndrome

1986 • 64 citations

Characterization of complement-fixing antibodies to peripheral nerve myelin in Guillain-Barr� syndrome

1990 • 63 citations

Guillain-Barré syndrome: Demonstration of antibodies to peripheral nerve tissue

2009 • 63 citations

Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man. Reconstitution of normal C8 from the mixture of two abnormal C8 molecules.

1983 • 62 citations

Inherited deficiency of the ninth component of complement in man.

1980 • 61 citations

MYASTHENIA GRAVIS

1900 • 60 citations

Immunohistochemical localisation of terminal complement component C9 in experimental allergic encephalomyelitis

1989 • 59 citations

Guillain-Barr� syndrome: Historical aspects

1990 • 59 citations

Multiple sclerosis: Serum-induced demyelination in vitro

1973 • 58 citations

Mechanisms of Acetylcholine Receptor Loss from the Neuromuscular Junction

1982 • 57 citations

Multiple sclerosis

1980 • 55 citations

Multiple Sclerosis: Serum Factor Producing Reversible Alterations in Bioelectric Responses

1966 • 55 citations

Detection of activated terminal complement (C5b-9) in cerebrospinal fluid from patients with central nervous system involvement of primary Sjogren's syndrome or systemic lupus erythematosus.

1987 • 53 citations

Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesions

1985 • 53 citations

Multiple Sclerosis: Basic Concepts and Hypothesis

1989 • 52 citations

Studies in myasthenia gravis: neonatal and juvenile types.

1956 • 51 citations

Reversible injury of cultured rat oligodendrocytes by complement.

1989 • 50 citations

Deficiency of the ninth component of complement in man.

1979 • 49 citations

MYASTHENIA GRAVIS: A CONSIDERATION OF ITS CAUSATION IN A STUDY OF FOURTEEN CASES<sup>1</sup>

1944 • 49 citations

Intrathecal complement activation in neurological diseases evaluated by analysis of the terminal complement complex

1987 • 48 citations

Cerebrospinal fluid C9 in demyelinating disease

1986 • 48 citations

Receptors, antibodies, and disease.

1984 • 47 citations

Cerebrospinal fluid immune complexes in systemic lupus erythematosus involving the central nervous system

1982 • 47 citations

Distinction between fixation of C1 and the activation of complement by natural IgM anti-hapten antibody: Effect of cell surface hapten density

1981 • 46 citations

Isolation of Membrane Attack Complex of Complement from Myelin Membranes Treated with Serum Complement

1984 • 45 citations

Vesicular demyelination induced by raised intracellular calcium

1985 • 44 citations

Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids.

1989 • 44 citations

Hydrolysis of myelin basic protein in human myelin by terminal complement complexes.

1988 • 44 citations

COMPLEMENT FACTORS IN MULTIPLE SCLEROSIS

1972 • 44 citations

The influence of nimodipine on cerebral blood flow autoregulation and blood-brain barrier

1988 • 43 citations

Experimental allergic neuritis: Evidence for the involvement of the P0 and P2 proteins

1975 • 41 citations

Relapsing experimental allergic encephalomyelitis an autoimmune model of multiple sclerosis

1985 • 40 citations

A Second Variant of Properdin Deficiency: The Detection of Properdin at Low Concentrations in Affected Males

1988 • 39 citations

Immunology and Alzheimer’s Disease

1988 • 39 citations

Anoxic injury of mammalian central white matter: Decreased susceptibility in myelin‐deficient optic nerve

1990 • 38 citations

Measurement of complement components in cerebral spinal fluid by radioimmunoassay in patients with multiple sclerosis

1980 • 36 citations

Presence of Immunoglobulins and Complements in the Amyloid Plaques in the Brain of Patients with Alzheimer’s Disease

1988 • 33 citations

Experimental allergic encephalomyelitis in cobra venom factor—treated and C4‐deficient guinea pigs

1978 • 33 citations

Circulating immune complexes in multiple sclerosis: Relation with disease activity

1982 • 32 citations

Prevention of Experimental Allergic Encephalomyelitis with Cobra Venom Factor

1971 • 31 citations

Allergic Encephalomyelitis: Effect of Complement Depletion with Cobra Venom

1971 • 24 citations

Antibrain antibodies in multiple sclerosis

1982 • 24 citations

The occurrence of precipitating antibodies in transfused Japanese patients with hereditary ninth component of complement deficiency and frequency of C9 deficiency

1987 • 23 citations

The Guillain-Barré Syndrome

1970 • 23 citations

Complement mediated serum cytotoxicity against oligodendrocytes: a comparison with other cells of the oligodendrocyte-type 2 astrocyte lineage

1990 • 22 citations

NEUROMUSCULAR BLOCKING ACTIVITY IN THE BLOOD OF PATIENTS WITH MYASTHENIA GRAVIS

1966 • 21 citations

Inherited deficiencies of complement and complement-related proteins

1986 • 20 citations

HUMORAL FACTORS INVOLVED IN IMMUNE PROCESSES IN MULTIPLE SCLEROSIS AND ALLERGIC ENCEPHALOMYELITIS

1977 • 18 citations

The occurrence, specificity, and role of neuroelectric blocking factors in multiple sclerosis

1978 • 17 citations

DEMONSTRATION OF COMPLEMENT IN SPINAL FLUID IN MULTIPLE SCLEROSIS

1965 • 16 citations

Terminal component of complement C9 in CSF and plasma of patients with MS and aseptic meningitis

1989 • 15 citations

Theories of the etiology of multiple sclerosis: a critical review.

1986 • 14 citations

Binding and activation of C1 by cell bound IgG: Activation depends on cell surface hapten density

1983 • 13 citations

Terminal component of complement (C9) in the cerebrospinal fluid of patients with multiple sclerosis and neurologic controls

1990 • 13 citations

AN ASSESSMENT OF CHANGES IN THE COMPLEMENT LEVEL OF MYASTHENIC SERA*

1966 • 12 citations

IMMUNOLOGICAL ASPECTS OF ALZHEIMER DISEASE: A REVIEW

1987 • 8 citations

General Scientific Session Afternoon Meeting Friday, April 29, 1977

1977 • 6 citations

The Effect of the Cleavage Peptide C3aDesArg of the Third Complement Component on the Accumulation of Leukocytes in Cerebrospinal Fluid (CSF) and on the Permeability of the Blood-CSF Barrier

1986 • 4 citations

Current Concepts About Multiple Sclerosis

1989 • 3 citations

The Development of Complement Activating Ability as an Age Related Factor in Murine Brains

1985 • 3 citations

Polymorphonuclear Leukocytes: The Phagocytic Cell in Host Resistance . Proceedings of a conference, Winter Park, Fla., Mar. 1974. Joseph A. Bellanti and Delbert H. Dayton, Eds. Raven, New York, 1975. xvi, 348 pp., illus. $19.75. A Monograph of the National Institute of Child Health and Human Development.

1975 • 1 citations

Deleted Work

1955 • 0 citations