Prostaglandins and the Digestive System

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins

1971 • 614 citations

The prostaglandins: a family of biologically active lipids.

1968 • 613 citations

Advances in prostaglandin and thromboxane research

1976 • 602 citations

Altered Enzymes in Ageing Human Fibroblasts

1972 • 408 citations

The Wider World

1974 • 358 citations

PROSTAGLANDIN SECRETION BY MEDULLARY CARCINOMA OF THE THYROID

1968 • 353 citations

Effects of Prostaglandins, Theophylline, and Cholera Exotoxin Upon Transmucosal Water and Electrolyte Movement in the Canine Jejunum

1971 • 351 citations

Enteropooling assay: A test for diarrhea produced by prostaglandins

1976 • 318 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

Small intestinal ulcers and intestinal flora in rats given indomethacin.

1969 • 293 citations

Effect of Prostaglandin E1 on Gastric Secretion and Ulcer Formation in the Rat

1968 • 285 citations

Inhibition of gastric secretion by prostaglandins

1967 • 285 citations

Age and Sleep

1964 • 254 citations

Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration.

1976 • 237 citations

Observations on the Effects of Infusion of Prostnglnndin E in Man

1959 • 232 citations

MICROGNATHIA

1947 • 224 citations

Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin

1971 • 217 citations

An Intestinal Disease Produced Experimentally by a Prostaglandin Deficiency

1975 • 213 citations

Gastric Antisecretory and Antiulcer Properties of PGE2, 15-Methyl PGE2, and 16,16-Dimethyl PGE2

1976 • 211 citations

PROSTAGLANDINS IN AMINE-PEPTIDE-SECRETING TUMOURS

1968 • 208 citations

Esophageal responses to distension and electrical stimulation

1969 • 207 citations

Effect of nerve stimulation on prostaglandin formation and release from the rat stomach

1967 • 194 citations

INVESTIGATION OF THE VASODILATOR AND ANTISECRETORY ROLE OF PROSTAGLANDINS IN THE RAT GASTRIC MUCOSA BY USE OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS

1975 • 182 citations

Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.

1968 • 178 citations

Release of Prostaglandin E1 from the Rat Stomach

1967 • 173 citations

Effect of Prostaglandin E1 on Glucose, Water, and Electrolyte Absorption in the Human Jejunum

1973 • 170 citations

EFFECT OF ORAL PROSTAGLANDIN E1 ON INTESTINAL TRANSIT IN MAN

1969 • 164 citations

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

1973 • 163 citations

Prostaglandin influences on intraocular pressure and pupil size

1967 • 161 citations

Studies on prostaglandin antagonists

1971 • 157 citations

The Effect of Prostaglandin

1972 • 154 citations

Role of Gastric Acid in Aspirin-Induced Gastric Irritation in the Rat

1967 • 153 citations

Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion

1973 • 142 citations

Effects of vasoactive agents on intestinal blood flow and motility in the dog

1969 • 132 citations

Effects of prostaglandins E₁ and E₂ on human, guinea‐pig and rat isolated small intestine

1968 • 130 citations

Mechanism of the Lower Esophageal Sphincter Relaxation ACTION OF PROSTAGLANDIN E1 AND THEOPHYLLINE

1973 • 128 citations

OCCURRENCE OF PROSTAGLANDIN E₂ IN THE HUMAN STOMACH, AND A STUDY OF ITS EFFECTS ON HUMAN ISOLATED GASTRIC MUSCLE

1968 • 128 citations

A rapid spectrophotometric assay for prostaglandin synthetase: Application to the study of non-steroidal antiinflammatory agents

1972 • 128 citations

Inhibition of Gastric Secretion in Man by Prostaglandin A1

1971 • 127 citations

Comparison of Prostaglandin E1 and Norepinephrine on the Gastric Mucosal Circulation

1970 • 122 citations

Chemotherapy of Systemic Mycoses

1974 • 120 citations

Some Biological Effects of Two Crystalline Prostaglandin Factors

1959 • 108 citations

Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1

1969 • 108 citations

Prostaglandins and cyclic AMP.

1970 • 102 citations

Cysteamine-Induced Duodenal Ulcers: A New Model to Test Antiulcer Agents

1974 • 101 citations

Prostaglandins and the gastrointestinal tract.

1973 • 95 citations

Adenosine-3',5'-monophosphate: intracellular mediator for methyl xanthine stimulation of gastric secretion.

1969 • 94 citations

Protective Effect of Prostaglandin E1 (PGE1) on Lysosomal Enzyme Release in Serotonin-Induced Gastric Ulceration

1973 • 93 citations

Total synthesis of 15-methylprostaglandins

1974 • 91 citations

EFFECT OF 15(R)15 METHYLPROSTAGLANDIN E2 METHYL ESTER ON HEALING OF GASTRIC ULCERS

1974 • 89 citations

Effect of prostaglandins E₁ and E₂ on intestinal motility in the guinea‐pig and rat

1968 • 87 citations

The Effect of 16,16-Dimethyl Prostaglandin E2 on Meal-Stimulated Gastric Acid Secretion and Serum Gastrin in Duodenal Ulcer Patients

1976 • 85 citations

Comparative Effects of Metoclopramide and Bethanechol on Lower Esophageal Sphincter Pressure in Reflux Patients

1975 • 84 citations

Adenosine-3′,5′ -Monophosphate: Intracellular Mediator for Methyl Xanthine Stimulation of Gastric Secretion

1969 • 83 citations

Cyclic AMP in the regulation of gastric secretion in dogs and humans

1973 • 83 citations

Effects of prostaglandins on the stomach and the intestine

1974 • 81 citations

Effect of Intravenous Prostaglandin F2α on Small Intestinal Function in Man

1973 • 81 citations

Comparison of Methylated Prostaglandin E2 Analogues Given Orally in the Inhibition of Gastric Responses to Pentagastrin and Peptone Meal in Man

1976 • 76 citations

Inhibition by prostaglandin E₁ of gastric secretion in the dog

1971 • 70 citations

Diarrhoeae in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg.

1975 • 70 citations

The Effect of Prostaglandin E<sub>1</sub> on the Pentagastrin-Stimulated Gastric Secretion in Man

1971 • 67 citations

Relative activity of prostaglandins E1, A1, E2 and A2 on lipolysis, platelet aggregation, smooth muscle and the cardiovascular system

1969 • 66 citations

Synthesis and biological properties of 16-alkylprostaglandins

1973 • 66 citations

Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man

1974 • 66 citations

Effect of gastric secretory inhibitors on the gastric mucosal barrier.

1975 • 61 citations

Action of oral metoclopramide on the gastrooesophageal junction in man

1973 • 61 citations

Prevention of Duodenal Ulcers by Administration of Prostaglandin E₂(PGE₂)

1971 • 60 citations

Diarrhoea associated with medullary carcinoma of the thyroid

1969 • 60 citations

Effect of prostaglandin 15 (R) 15 methyl-E2-methyl ester on the gastric mucosa in patients with peptic ulceration — An endoscopic and histological study

1974 • 60 citations

Stimulation of the gastric mucosa by adenosine-3',5'-monophosphate.

1965 • 58 citations

Prostaglandin E in peptic ulcer disease

1974 • 57 citations

The effect of prostaglandin E1 on canine gastric acid secretion and gastric mucosal blood flow

1972 • 57 citations

(15S)-15-Methylprostaglandins

1972 • 57 citations

THE ROLE OF CYCLIC AMP IN GASTRIC SECRETION*

1971 • 57 citations

Adenosine 3', 5' -Monophosphate (Cyclic Amp) and Secretion in the Canine Stomach

1972 • 57 citations

The Prostaglandins: Progress In Research

1973 • 56 citations

Effects of an Orally Administered Prostaglandin Analogue (16,16-Dimethyl Prostaglandin E2) on Human Gastric Secretion

1975 • 56 citations

Effect of aspirin on gastric secretion

1964 • 56 citations

Wirkung von Prostaglandin E1 auf die basale Magensekretion des Menschen

1970 • 55 citations

The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.

1975 • 51 citations

Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations

1973 • 51 citations

Prostaglandin: Liberation from and formation in perfused frog intestine

1970 • 50 citations

Prostaglandins

1974 • 50 citations

Intestinal lesions produced by prednisolone: prevention (cytoprotection) by 16,16-dimethyl prostaglandin E2.

1978 • 49 citations

Effects of Prostaglandin E1 on Pancreatic Exocrine Function

1971 • 49 citations

Comparison of the Effects of Prostaglandins E1, E2, and A2, and of Hypovolumic Hypotension on the Lower Esophageal Sphincter

1973 • 49 citations

Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.

1975 • 48 citations

Prostaglandin action on pancreatic blood flow and on electrolyte and enzyme secretion by exocrine pancreas in vivo and in vitro

1972 • 47 citations

Pathophysiology of stress ulcer and its prevention

1975 • 46 citations

Indomethacin

1968 • 46 citations

Cyclic AMP and gastric secretion

1972 • 44 citations

Gastric Secretory Inhibition Induced by Three Methyl Analogs of Prostaglandin E₂ Administered Intragastrically to Man

1974 • 44 citations

Cyclic GMP Response in vivo to Cholinergic Stimulation of Gastric Mucosa

1974 • 41 citations

Inhibition of gastric acid secretion by a potent synthetic prostaglandin

1970 • 40 citations

Infusion of long-chain fatty acid anions by continuous-flow centrifugation

1969 • 38 citations

Prostaglandin E2 and the stimulation of rat gastric acid secretion by dibutyryl cyclic 3′,5′-AMP

1974 • 38 citations

Gastric Antisecretory Effect of 15(R)-15-Methyl PGE2, Methyl Ester and of 15(S)-15-Methyl PGE2, Methyl Ester

1975 • 37 citations

The effect of orally and intravenously administered prostaglandin 16:16 dimethyl E2 methyl ester on human gastric acid secretion

1973 • 36 citations

Cyclic GMP and gastric acid secretion

1974 • 35 citations

Circadian variation of prostaglandin E (PGE) production in human gastric juice

1974 • 35 citations

Evaluation of gastric acid as a factor in drug-induced gastric hemorrhage in the rat.

1969 • 34 citations

Evaluation of Gastric Acid as a Factor in Drug-Induced Gastric Hemorrhage in the Rat

1969 • 34 citations

The effect of prostaglandin A1 and E1 on canine hepatic bile flow

1975 • 33 citations

Nutmeg for Diarrhea of Medullary Carcinoma of Thyroid

1973 • 33 citations

Inhibition of human gastric secretion by prostaglandin

1973 • 32 citations

Salivation induced by prostaglandin F_2α and modification of the response by atropine and physostigmine

1972 • 32 citations

Effect of 16,16-Dimethyl PGE₂ on Gastric Emptying and Intestinal Transit of a Barium-food Test Meal in Man

1975 • 30 citations

Further observations on the interaction of prostaglandin F2α with cholinergic mechanisms in canine salivary glands

1974 • 29 citations

Inhibition of Stimulated Gastric Secretion by an Orally Administered Prostaglandin Capsule

1976 • 29 citations

The effect of locally administered prostaglandin 15 (R) 15 methyl-E2 methyl ester on gastric ulcer formation in the shay rat preparation

1974 • 28 citations

Effects of Prostaglandins on the Gastrointestinal Tract

1972 • 28 citations

Inhibition of glucose absorption by prostaglandins E1, E2 and F2α

1972 • 27 citations

Prostaglandins as factors in diseases of the alimentary tract.

1976 • 26 citations

Duodenal ulcers produced in rats by propionitrile: Factors inhibiting and aggravating such ulcers

1975 • 26 citations

Prostaglandins, Nutmeg and Diarrhea

1974 • 26 citations

Effects of prostaglandin E1 on net and unidirectional movements of water and electrolytes across the jejunal mucosa in man.

1971 • 25 citations

Gastric Secretory Inhibition by Certain Methyl Analogs of Prostaglandin E₂ following Intestinal Administration in Man

1974 • 23 citations

E-type Prostaglandins and Gastric Acid Secretion in the Rat

1972 • 23 citations

Effect of Prostaglandin F2 and Gastrin Pentapeptide on the Lower Esophageal Sphincter

1972 • 22 citations

INHIBITION OF GASTRIC ACID SECRETION IN THE RAT BY SYNTHETIC PROSTAGLANDIN ANALOGUES

1971 • 21 citations

Inhibition of gastric secretion in the dog by 16,16-dimethyl prostaglandin E2

1976 • 21 citations

Effects of prostaglandin E2 (PGE2) on the output of histamine and acid in rat gastric secretion induced by pentagastrin or histamine.

1969 • 20 citations

Proceedings: Effects of prostaglandin E2 on rat gastric mucosal blood flow, as determined by 14C-aniline clearance.

1972 • 19 citations

Reply of the author

1975 • 19 citations

Effects of prostaglandin E₁ on acid secretion, mucosal histamine content and histidine decarboxylase activity in rat stomach

1973 • 18 citations

Oral anti-ulcer activity of a synthetic prostaglandin analogue (9-oxoprostanoic acid: AY-22,469)

1973 • 17 citations

Prostaglandin E in cholera toxin-induced intestinal secretion

1975 • 17 citations

Prostaglandin-induced choleresis in the rat

1975 • 16 citations

Prostaglandin Inhibition of Innervated Antral Motility in Dogs

1969 • 16 citations

Effect of aspirin on explanted gastric mucosa

1966 • 15 citations

[Effects of prostaglandin on the function of the gastric secretion].

1970 • 13 citations

Effect of Two Methylated Prostaglandin E₂ Analogs on Gastroduodenal Pressure in Man

1975 • 13 citations

Proceedings: The effect of prostaglandins and of anti-inflammatory drugs on the oesophagus and the cardiac sphincter in man.

1973 • 12 citations

Effect of methylated PGE2 analogs given orally on pancreatic response to secretin in man

1977 • 12 citations

The release of prostaglandin from the oesophagus and the stomach of the frog (Rana temporaria)

1971 • 12 citations

The Effect of Prostaglandin E₁on the Release of Gastrin and Gastric Secretion on Dogs

1973 • 12 citations

Effect of synthetic 15-methyl analog of prostaglandin E2 on gastric secretion and peptic ulcer formation.

1974 • 11 citations

Effects of indomethacin on intestinal secretion, prostaglandin E and cyclic AMP: Evidence against a role for prostaglandins in cholera toxin-induced secretion

1975 • 11 citations

Effect of Prostaglandins E1 and A1 on the Gastric Circulation in Dogs

1972 • 11 citations

The effect of orally administered prostaglandins A1, A2 and 15 Epi-A2 on human gastric acid secretion

1973 • 10 citations

Prostaglandins and the Gastro-intestinal Tract

1972 • 10 citations

Studies on the mode of action of cyclic 3'5'-AMP and prostaglndin E 2 on rat gastric acid secretion and mucosal blood flow.

1972 • 10 citations

Prostaglandin 15 (R) 15-methyl-E2 Methyl Ester for Suppression of Gastric Acidity in Gravida at Term

1973 • 9 citations

Effect of Prostaglandin-E<sub>2</sub> on Gastric Secretion and on Gastric Circulation of Totally Isolated <i>ex vivo</i> Canine Stomach

1974 • 9 citations

EFFECT OF PROSTAGLANDINS AND CYLIC AMP ON GASTRIC SECRETION

1971 • 8 citations

Proceedings: Failure of burimamide and (15S)-15-methyl prostaglandin E2 to prevent histamine-induced gastric mucosal hyperaemia in the rat.

1974 • 7 citations

Prostaglandins: a possible mediator of diarrhea in endocrine syndromes.

1970 • 7 citations

Parameters of the control of acid secretion in the isolated blood-perfused stomach.

1972 • 6 citations

The biological assay of prostaglandins A1 and A2.

1969 • 6 citations

Studies on the Site of Production of Diarrhoea Induced by Prostaglandins

1974 • 6 citations

Effects of aspirin on canine gastric prostaglandin output and mucosal permeability.

1974 • 5 citations

Influence of a synthetic prostaglandin analog on pancreatic secretion.

1976 • 5 citations

[Occurrence of prostaglandin E1 in the mucous membrane layer of swine large intestine].

1968 • 4 citations

Proceedings: A proposed role for PGE2 in the genesis of stress-induced gastric ulcers.

1974 • 3 citations

EFFECTS OF H2-RECEPTOR ANTAGONISTS, PROSTAGLANDINS E2 AND l6:l6-DIMETRTL-E2-METHYL ESTER ON GASTRIC ACID SECRETION, MUCOSAL BLOOD FLOW AND ULCERATION

1977 • 2 citations

10th Meeting of the European Association for the Study of the Liver (Part 2 of 6)

1975 • 2 citations

[Isolation of prostaglandin E like substances from the mucous membrane layer of large intestine of pig].

1968 • 2 citations

Effect of prostaglandin e1 on the acidity of gastric juices

1970 • 1 citations

“Magnification before Reproduction”

1973 • 1 citations

MODE OF ACTIONS OF PROSTAGLANDINS E2, Fla AND F2a IN THE DOG SALIVARY GLAND

1977 • 1 citations

Study of the inhibitory action of prostaglandin on gastric secretion in rat and man

1970 • 1 citations

SYNTHETIC PROSTAGLANDIN IN GASTRIC ULCER

1974 • 1 citations