Poly(ADP-ribose) Synthetase

Structure of Chromatin

1977 • 1,276 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

Nucleosome Structure

1980 • 923 citations

A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids

1973 • 757 citations

Template properties of liver chromatin

1966 • 530 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

Preparation of Native Chromatin and Damage Caused by Shearing

1975 • 413 citations

ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.

1980 • 378 citations

On the formation of a novel adenylic compound by enzymatic extracts of liver nuclei

1966 • 337 citations

Studies on the Polymer of Adenosine Diphosphate Ribose

1967 • 306 citations

Poly(ADP-ribose) and ADP-ribosylation of proteins

1976 • 283 citations

Single strand interruptions in DNA and the effects of caffeine in Chinese hamster cells irradiated with ultraviolet light

1969 • 221 citations

ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites.

1980 • 213 citations

Poly(adenosine diphosphate ribose)

1973 • 210 citations

Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei.

1981 • 198 citations

ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site.

1980 • 185 citations

Enzymic Adenosine Diphosphate Ribosylation of Histone and Poly Adenosine Diphosphate Ribose Synthesis in Rat Liver Nuclei

1968 • 184 citations

Isolation of an avian erythrocyte protein possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase

1978 • 175 citations

Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.

1981 • 173 citations

Evidence for adenosine diphosphate ribosylation of Ca2+, Mg2+-dependent endonuclease.

1975 • 166 citations

Post‐Replication Repair of DNA in Ultraviolet‐Irradiated Mammalian Cells

1972 • 157 citations

ADP-Ribosylation Reactions

1982 • 152 citations

Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage.

1979 • 149 citations

Polymerization of the adenosine 5′-diphosphate-ribose moiety of nicotinamide-adenine dinucleotide by nuclear enzyme. I. Enzymatic reactions

1967 • 140 citations

Specific inhibition of poly adpribose polymerase by thymidine and nicotinamide in HeLa cells

1971 • 139 citations

Bovine thymus poly(adenosine diphosphate ribose) polymerase. Physical properties and binding to DNA.

1980 • 138 citations

THE ISOLATION AND PROPERTIES OF THE ISONICOTINIC ACID HYDRAZIDE ANALOGUE OF DIPHOSPHOPYRIDINE NUCLEOTIDE

1954 • 129 citations

Enzyme-bound early product of purified poly(ADP-ribose) polymerase

1977 • 123 citations

Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5′-methyl nicotinamide

1971 • 122 citations

Polymerization of the adenosine 5′-diphosphate ribose moiety of NAD by rat liver nuclear enzyme

1967 • 120 citations

Properties of the Complex between Histone H1 and Poly(ADP‐ribose) Synthesised in HeLa Cell Nuclei

1977 • 119 citations

Stimulation of nuclear poly(adenosine diphosphate-ribose) polymerase activity from HeLa cells by endonucleases

1975 • 117 citations

Purification and characterization of poly(ADP-ribose) synthetase from calf thymus.

1979 • 113 citations

Purification and properties of poly(adenosine diphosphate ribose) synthetase.

1977 • 112 citations

Bovine thymus poly(adenosine diphosphate ribose) polymerase.

1978 • 112 citations

Metabolic Interconversion of Enzymes 1980

1981 • 109 citations

Enzymic Adenosine Diphosphoribosylation of Nuclear Proteins

1969 • 107 citations

A General Procedure for the Isolation of “Minor” Nucleosides from Ribonucleic Acid Hydrolysates^*

1965 • 106 citations

Poly ADP-ribosylation of DNA-dependent RNA polymerase I from quail oviduct. Dependence on progesterone stimulation.

1976 • 99 citations

Chapter 15 The Isolation and Purification of the High Mobility Group (HMG) Nonhistone Chromosomal Proteins

1977 • 98 citations

Purification of ADP-ribosylated nuclear proteins by covalent chromatography on dihydroxyboryl polyacrylamide beads and their characterization.

1978 • 96 citations

Purification and characterization of the major nonhistone protein acceptor for poly(adenosine diphosphate ribose) in HeLa cell nuclei

1980 • 95 citations

Induction of erythroid differentiation of murine erythroleukemia cells by nicotinamide and related compounds.

1979 • 90 citations

Macromolecular enzymatic product of NAD+ in liver mitochondria.

1975 • 89 citations

Adenosine Diphosphoribosylation of Certain Basic Chromosomal Proteins in Isolated Trout Testis Nuclei

1977 • 87 citations

Properties of Purified Calf Thymus Poly(Adenosine Diphosphate Ribose) Polymerase. Comparison of the DNA-Independent and the DNA-Dependent Enzyme

1979 • 86 citations

Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets

1980 • 85 citations

Amino acid-specific ADP-ribosylation. Identification of an arginine-dependent ADP-ribosyltransferase in rat liver.

1981 • 81 citations

The higher order repeat structure of chromatin is built up of globular particles containing eight nucleosomes

1978 • 78 citations

Purification and Properties of Poly(ADP‐ribose) Polymerase from Pig‐Thymus Nuclei

1978 • 77 citations

Poly(adenosine diphosphate-ribose) polymerase: the distribution of a chromosome-associated enzyme within the chromatin substructure

1977 • 76 citations

Covalent modification of proteins by metabolites of NAD+.

1976 • 76 citations

Cytoplasmic poly(ADP-ribose) polymerase during the HeLa cell cycle

1975 • 75 citations

Two Different Types of Bonds Linking Single ADP‐Ribose Residues Covalently to Proteins

1978 • 75 citations

From Gene to Protein: Information Transfer in Normal and Abnormal Cells

1979 • 73 citations

Initiation of poly(ADP-ribosyl) histone synthesis by poly(ADP-ribose) synthetase.

1980 • 71 citations

ADP-Ribosylated Histone H1 from HeLa Cultures. Fundamental Differences to (ADP-Ribose)n-Histone H1 Conjugates Formed in vitro

1978 • 70 citations

Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum

1975 • 70 citations

Inhibition of poly(ADP‐ribose) polymerase by methylated xanthines and cytokinins

1978 • 68 citations

Poly(Adenosine Diphosphate Ribose) is Covalently Linked to Nuclear Proteins by Two Types of Bonds

1976 • 67 citations

Poly adenosine diphosphate ribose synthesis associated with chromatin

1968 • 65 citations

Poly(ADP-ribosy)ation of nuclear proteins. Enzymatic elongation of chemically synthesized ADP-ribose-histone adducts.

1979 • 64 citations

Immunohistochemical demonstration of poly(adenosine diphosphate-ribose) in nuclei of various rat tissues.

1980 • 63 citations

Modulation of Protein Function

1979 • 62 citations

Nuclear protein modification and chromatin substructure. 2. Internucleosomal localization of poly(adenosine diphosphate-ribose) polymerase

1978 • 61 citations

Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine

1975 • 59 citations

Purification and properties of calf thymus polyadenosine diphosphate ribose polymerase

1977 • 57 citations

Poly(ADP-ribose) synthesis, a marker of granulocyte differentiation.

1980 • 56 citations

Poly(adenosine diphosphate ribose) synthetase activity in nuclei of dividing and of non-dividing but differentiating intestinal epithelial cells

1979 • 55 citations

The in vivo distribution of immunoreactive larger than tetrameric polyadenosine diphosphoribose in histone and non-histone protein fractions of rat liver.

1979 • 52 citations

Poly(adenosine diphosphate ribose) Synthesis in Soluble Extracts of Animal Organs

1972 • 51 citations

Relationship between nicotinamide adenine dinucleotide concentration and in vitro synthesis of poly(adenosine diphosphate ribose) on purified nucleosomes

1980 • 50 citations

Complete dependency of poly(ADP-ribose) synthesis on DNA and its inhibition by actinomycin D

1972 • 50 citations

Bovine thymus poly(ADP-ribose) polymerase histone-dependent and Mg2+-dependent reaction.

1979 • 50 citations

ADP-ribosylation of diadenosine 5',5“-P1,P4-tetraphosphate by poly(ADP-ribose) polymerase in vitro.

1981 • 49 citations

Mode of enzyme-bound poly(ADP-ribose) synthesis and histone modification by reconstituted poly(ADP-ribose) polymerase-DNA-cellulose complex.

1981 • 48 citations

Nucleosome periodicity in HeLa cell chromatin as probed by micrococcal nuclease.

1979 • 47 citations

ADP-ribosylation of isolated nuclei from HeLa cells, rat liver, fetal rat liver, and Novikoff hepatoma. Effect of nicotinamide adenine dinucleotide analogs on template activity for DNA synthesis, incorporation into nuclear proteins, and a new 1''-3' osidic linkage.

1977 • 45 citations

Characterization of a putative poly(adenosine diphosphate ribose)-chromatin complex

1980 • 43 citations

A nuclear protein-modifying enzyme is responsive to ordered chromatin structure

1978 • 43 citations

Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver

1968 • 42 citations

ADP-ribosylation of nuclear protein A24

1978 • 42 citations

Demonstration of high molecular weight poly (adenosine diphosphate ribose)

1978 • 41 citations

Renaturation of DNA: a novel reaction of histones

1981 • 40 citations

Poly (ADP‐ribose) Polymerase from Ehrlich Ascites Tumor Cells

1978 • 40 citations

Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme.

1975 • 39 citations

Poly(adenosine diphosphate-ribose). XIII. Effects of deoxyribonucleic acid and histone on the number and length of chains of poly(adenosine diphosphate-ribose)

1973 • 38 citations

Effect of polyamines and divalent cations on histone H1-poly(adenosine diphosphate ribose) complex formation

1978 • 38 citations

Effect of polyamines and Mg++ on poly(ADP-ribose) synthesis and ADP-ribosylation of histones in wheat

1979 • 37 citations

Adenosine diphosphate ribosylation of histone H1 by purified calf thymus polyadenosine diphosphate ribose polymerase

1980 • 35 citations

Immunofluorescent staining of poly(ADP-ribose) in situ in HeLa cell chromosomes in the M phase.

1981 • 35 citations

Effect of polyamines on ADP-ribosylation of nuclear proteins from rat liver

1977 • 35 citations

Synthesis of polyadenosine diphosphate ribose by isolated nuclei of swine aortic tissue

1974 • 33 citations

Reconstitution of HeLa cell poly(adenosine diphosphate ribose) polymerase with purified oligonucleosomal chromatin

1980 • 32 citations

Purification of Poly(ADP‐ribose) Polymerase from Ehrlich Ascites Tumor Cells by Chromatography on DNA‐Agarose

1976 • 30 citations

Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould dictyostelium discoideum

1979 • 28 citations

Inhibition of ADP-ribosylation of histone by diadenosine 5′, 5‴-p1, p4-tetraphosphate

1981 • 28 citations

Poly(Adenosine Diphosphoribose) Polymerase in Mammalian Nuclei

1973 • 26 citations

The Modification of Nuclear Proteins by ADP‐ribosylation

1977 • 26 citations

Characterization of the NAD+ Glycohydrolase Associated with the Rat Liver Nuclear Envelope1

1976 • 25 citations

Poly ADP-ribose polymerase: Self-ADP-ribosylation, the stimulation by DNA, and the effects on nucleosome formation and stability

1979 • 23 citations

Influence of polynucleotides on poly (adenosine diphosphate ribose) synthetase activity of rat liver

1973 • 22 citations

Seminar on Poly(ADP-Ribose) and ADP-ribosylation of Protine1

1975 • 22 citations

Effect of polyamines on purified poly(ADP-ribose) synthetase from rat liver nuclei

1981 • 22 citations

Poly(ADP‐ribose) metabolizing enzymes in nuclei and nucleoli of Tetrahymena Pyriformis

1978 • 22 citations

Differential Effects of Cycloheximide and Trenimon on Alkaline Ribonuclease and on Ribonuclease Inhibitor in Human Amnion Cells

1968 • 20 citations

Non‐preferential localization of poly(ADP‐ribose) polymerase activity in transcriptionally active chromatin

1978 • 19 citations

Effect of polyamines on ADP-ribosylation by chick-embryo-liver nuclei

1980 • 19 citations

Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase

1975 • 19 citations

Studies on polymer of adenosine diphosphate ribose

1969 • 18 citations

Highly effective DNA in stimulating poly(ADP-ribose) polymerase reaction

1979 • 17 citations

Polyamine induced changes in the ADP-ribosylation of nuclear proteins from rat liver

1978 • 16 citations

Poly(ADP-Ribose) Synthesis in Nucleoli and ADP-Ribosylation of Nucleolar Proteins in Mouse Ascites Tumor Cells In Vitro

1981 • 15 citations

In vitro ADP‐ribosylation of histones by purified calf thymus polyadenosine diphosphate ribose polymerase

1980 • 15 citations

IMMUNOHISTOCHEMICAL DEMONSTRATION OF POLY(ADENOSINE DIPHOSPHATE‐RIBOSE) SYNTHESIS IN HUMAN SKIN

1982 • 14 citations

Glucocorticoid-induced changes in poly(ADP-ribose) synthetase activity from chick embryo liver

1980 • 13 citations

POLY ADENOSINE DIPHOSPHATE RIBOSE SYNTHESIS AND NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSGLYCOSIDASES

1968 • 12 citations

EMBO Workshop and 14. Konferenz der Gesellschaft für Biologische Chemie. Structure and Function of Poly(ADP-Ribose)

1972 • 12 citations

Immunochemical properties of unmodified and automodified poly(ADP-ribose) synthetases

1980 • 12 citations

A new method for oligo(ADP-ribose) fractionation according to chain length

1981 • 11 citations

Studies on poly ADPR polymerase using the specific antibody

1980 • 11 citations

The effect of phenones on poly(adenosine diphosphate ribose) synthetase from porcine thymus

1980 • 10 citations

POLYMERIZATION OF ADPR MOIETY OF NAD BY NUCLEAR ENZYME PREPARATION

1968 • 9 citations

Properties of Poly(Adenosine Diphosphate Ribose) Polymerase from Baby-Hamster Kidney Cells (BHK-21/C13)

1977 • 3 citations

[130] Adenosine diphosphoribosyltransferase in chromatin

1971 • 3 citations

<b>METABOLISM AND FUNCTION OF POLY(ADP-RIBOSE) IN NUCLEI OF RAT PERITONEAL </b><b>MACROPHAGES </b>

1980 • 3 citations

[24] Poly(ADP-ribose) synthetase from rat liver nuclei

1980 • 1 citations