Laser spectroscopy for breath analysis: towards clinical implementation
Data up to Jan 2025
Total Citations Per Year
Abstract
References (169)
Encyclopedia of Analytical Chemistry
2006 • 7,037 citations
Electronic Nose: Current Status and Future Trends
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Mid-infrared frequency combs
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Increased amount of nitric oxide in exhaled air of asthmatics
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Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
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Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography
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A review of the volatiles from the healthy human body
2014 • 914 citations
Mid-infrared frequency comb based on a quantum cascade laser
2012 • 750 citations
The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
2014 • 648 citations
Breath Analysis Using Laser Spectroscopic Techniques: Breath Biomarkers, Spectral Fingerprints, and Detection Limits
2009 • 548 citations
Dual-comb spectroscopy based on quantum-cascade-laser frequency combs
2014 • 457 citations
Applications of quartz tuning forks in spectroscopic gas sensing
2005 • 371 citations
The potential of the hydrocarbon breath test as a measure of lipid peroxidation
1994 • 362 citations
Review article: 13C‐urea breath test in the diagnosis of Helicobacter pylori infection – a critical review
2004 • 356 citations
Correlation of breath ammonia with blood urea nitrogen and creatinine during hemodialysis
2001 • 337 citations
Solid-state gas sensors for breath analysis: A review
2014 • 335 citations
Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis
2008 • 311 citations
A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gut
2017 • 286 citations
Breath acetone monitoring by portable Si:WO3 gas sensors
2012 • 281 citations
Nitric Oxide (NO) Mediates the Inhibition of Form-Deprivation Myopia by Atropine in Chicks
2016 • 278 citations
Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications
2014 • 273 citations
Stable Isotope Ratios Using Cavity Ring-Down Spectroscopy: Determination of 13C/12C for Carbon Dioxide in Human Breath
2002 • 244 citations
Spectroscopy of the methane<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>ν</mml:mi><mml:mn>3</mml:mn></mml:msub></mml:math>band with an accurate midinfrared coherent dual-comb spectrometer
2011 • 240 citations
Fast, low-noise, mode-by-mode, cavity-enhanced absorption spectroscopy by diode-laser self-locking
2005 • 238 citations
Exhaled breath analysis: a review of ‘breath-taking’ methods for off-line analysis
2017 • 235 citations
The importance of methane breath testing: a review
2013 • 217 citations
Human breath analysis via cavity-enhanced optical frequency comb spectroscopy
2007 • 211 citations
Mid-infrared quantum cascade laser based off-axis integrated cavity output spectroscopy for biogenic nitric oxide detection
2004 • 181 citations
Analysis of Exhaled Breath for Disease Detection
2014 • 180 citations
Current status of midinfrared quantum and interband cascade lasers for clinical breath analysis
2010 • 175 citations
Mass spectrometry for real-time quantitative breath analysis
2014 • 165 citations
In Vivo Noninvasive Monitoring of Glucose Concentration in Human Epidermis by Mid-Infrared Pulsed Photoacoustic Spectroscopy
2012 • 160 citations
Breath acetone as a potential marker in clinical practice
2017 • 156 citations
Cavity-enhanced optical frequency comb spectroscopy in the mid-infrared application to trace detection of hydrogen peroxide
2012 • 154 citations
Analysis of volatile organic compounds in exhaled breath to diagnose ventilator-associated pneumonia
2015 • 151 citations
Impact of sampling procedures on the results of breath analysis
2008 • 149 citations
High Malnutrition Rate in Venezuelan Yanomami Compared to Warao Amerindians and Creoles: Significant Associations WITH Intestinal Parasites and Anemia
2013 • 147 citations
NO trace gas sensor based on quartz-enhanced photoacoustic spectroscopy and external cavity quantum cascade laser
2010 • 132 citations
Watt-level fiber-based femtosecond laser source tunable from 28 to 36 μm
2016 • 127 citations
Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders
2013 • 126 citations
Ammonia in breath and emitted from skin
2013 • 122 citations
Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath
2006 • 121 citations
Volatile Biomarkers in Breath Associated With Liver Cirrhosis — Comparisons of Pre- and Post-liver Transplant Breath Samples
2015 • 121 citations
A water isotope (2H, 17O, and 18O) spectrometer based on optical feedback cavity-enhanced absorption for in situ airborne applications
2006 • 117 citations
Detection of an Extended Human Volatome with Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry
2013 • 117 citations
Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study)
2004 • 115 citations
Mid-infrared virtually imaged phased array spectrometer for rapid and broadband trace gas detection
2012 • 114 citations
Mid-infrared dual-comb spectroscopy with an optical parametric oscillator
2013 • 113 citations
Ultrasensitive laser spectroscopy for breath analysis
2011 • 110 citations
ICL-based TDLAS sensor for real-time breath gas analysis of carbon monoxide isotopes
2017 • 109 citations
Mid-infrared optical frequency combs based on difference frequency generation for molecular spectroscopy
2015 • 99 citations
Data interpretation in breath biomarker research: pitfalls and directions
2012 • 98 citations
Compact quantum cascade laser based quartz-enhanced photoacoustic spectroscopy sensor system for detection of carbon disulfide
2016 • 89 citations
Monitoring of selected skin- and breath-borne volatile organic compounds emitted from the human body using gas chromatography ion mobility spectrometry (GC-IMS)
2018 • 87 citations
Nitric oxide breath testing by tunable-diode laser absorption spectroscopy: application in monitoring respiratory inflammation
2002 • 85 citations
Exhaled volatile organic compounds for phenotyping chronic obstructive pulmonary disease: a cross-sectional study
2012 • 85 citations
Adsorption of ammonia on treated stainless steel and polymer surfaces
2013 • 83 citations
Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO 2 , CO and N 2 O) by infrared laser spectroscopy
2011 • 78 citations
Application of laser spectroscopy for measurement of exhaled ethane in patients with lung cancer
2005 • 77 citations
Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review
2016 • 77 citations
Online recording of ethane traces in human breath via infrared laser spectroscopy
2003 • 76 citations
Comparison of classification methods in breath analysis by electronic nose
2015 • 76 citations
Study of the Exhaled Acetone in Type 1 Diabetes Using Quantum Cascade Laser Spectroscopy
2014 • 73 citations
Two-crystal mid-infrared optical parametric oscillator for absorption and dispersion dual-comb spectroscopy
2014 • 72 citations
High-resolution multi-heterodyne spectroscopy based on Fabry-Perot quantum cascade lasers
2014 • 72 citations
Dual comb operation of λ ∼ 8.2 μm quantum cascade laser frequency comb with 1 W optical power
2017 • 72 citations
Fourier transform and Vernier spectroscopy using an optical frequency comb at 3–54 μm
2016 • 71 citations
Fractional exhaled nitric oxide-measuring devices: technology update
2016 • 70 citations
Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy
2007 • 69 citations
A portable low-power QEPAS-based CO2 isotope sensor using a fiber-coupled interband cascade laser
2017 • 68 citations
Determination of exhaled nitric oxide distributions in a diverse sample population using tunable diode laser absorption spectroscopy
2006 • 67 citations
Methods of NO detection in exhaled breath
2013 • 67 citations
Optical-feedback cavity-enhanced absorption spectroscopy with a quantum cascade laser
2010 • 67 citations
High resolution measurements of carbon monoxide along a late Holocene Greenland ice core: evidence for in situ production
2014 • 66 citations
Dual-comb spectroscopy in the spectral fingerprint region using OPGaP optical parametric oscillators
2017 • 66 citations
On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation damage of the human skin
1999 • 64 citations
A quantum cascade laser-based optical feedback cavity-enhanced absorption spectrometer for the simultaneous measurement of CH4 and N2O in air
2010 • 64 citations
Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements
2008 • 63 citations
Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry—a pilot study on tobacco smokers
2016 • 63 citations
Online monitoring of ethane traces in exhaled breath with a difference frequency generation spectrometer
2006 • 63 citations
A calibration-free ammonia breath sensor using a quantum cascade laser with WMS 2f/1f
2013 • 61 citations
Pulsed quantum-cascade laser-based sensor for trace-gas detection of carbonyl sulfide
2004 • 61 citations
Comparison of breath gases, including acetone, with blood glucose and blood ketones in children and adolescents with type 1 diabetes
2014 • 61 citations
Real-time breath gas analysis of CO and CO2 using an EC-QCL
2017 • 61 citations
Atomic “bomb testing”: the Elitzur–Vaidman experiment violates the Leggett–Garg inequality
2016 • 60 citations
Demonstration of a Mid-Infrared Cavity Enhanced Absorption Spectrometer for Breath Acetone Detection
2012 • 59 citations
Real time ammonia detection in exhaled human breath using a distributed feedback quantum cascade laser based sensor
2010 • 59 citations
Sensitive detection of ammonia and ethylene with a pulsed quantum cascade laser using intra and interpulse spectroscopic techniques
2008 • 57 citations
Wine analysis by FastGC proton-transfer reaction-time-of-flight-mass spectrometry
2014 • 56 citations
Clinical applications of breath testing
2010 • 55 citations
Stable isotope and high precision concentration measurements confirm that all humans produce and exhale methane
2016 • 55 citations
Exhaled breath profiling using broadband quantum cascade laser-based spectroscopy in healthy children and children with asthma and cystic fibrosis
2016 • 54 citations
Pentane and other volatile organic compounds, including carboxylic acids, in the exhaled breath of patients with Crohn’s disease and ulcerative colitis
2017 • 54 citations
Mid-infrared cavity leak-out spectroscopy for ultrasensitive detection of carbonyl sulfide
2005 • 53 citations
Biochemical pathways of breath ammonia (NH3) generation in patients with end-stage renal disease undergoing hemodialysis
2016 • 53 citations
Shot-noise Limited Faraday Rotation Spectroscopy for Detection of Nitric Oxide Isotopes in Breath, Urine and Blood
2015 • 52 citations
Water isotope ratio (δ2H and δ18O) measurements in atmospheric moisture using an optical feedback cavity enhanced absorption laser spectrometer
2010 • 51 citations
Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy
2011 • 51 citations
Intracavity trace molecular detection with a broadband mid-IR frequency comb source
2013 • 48 citations
Quantum cascade laser-based carbon monoxide detection on a second time scale from human breath
2006 • 48 citations
Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy
2009 • 47 citations
Extended NO analysis in health and disease
2012 • 47 citations
Microresonator-based high-resolution gas spectroscopy
2017 • 46 citations
Detection of disease markers in human breath with laser absorption spectroscopy
2016 • 46 citations
Measurement of acetaldehyde in exhaled breath using a laser absorption spectrometer
2007 • 45 citations
The origin of mouth-exhaled ammonia
2014 • 45 citations
In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care
2016 • 43 citations
Mid-infrared multiheterodyne spectroscopy with phase-locked quantum cascade lasers
2017 • 42 citations
Determination of endogenous methane formation by photoacoustic spectroscopy
2013 • 42 citations
Background levels and diurnal variations of hydrogen cyanide in breath and emitted from skin
2011 • 41 citations
Frequency stability characterization of a quantum cascade laser frequency comb
2016 • 40 citations
Optical frequency comb spectroscopy at 3-5.4 {\mu}m with a doubly resonant optical parametric oscillator
2016 • 40 citations
Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath
2009 • 39 citations
Analysis of exhaled breath for screening of lung cancer patients
2010 • 39 citations
Real-time trace gas sensing of ethylene, propanal and acetaldehyde from human skinin vivo
2006 • 36 citations
Optical feedback cavity-enhanced absorption spectroscopy with a 3.24 μm interband cascade laser
2015 • 35 citations
Part per trillion nitric oxide measurement by optical feedback cavity-enhanced absorption spectroscopy in the mid-infrared
2017 • 35 citations
Acetylene in breath: background levels and real-time elimination kinetics after smoking
2010 • 35 citations
Quantum cascade laser-based sensor for detection of exhaled and biogenic nitric oxide
2013 • 34 citations
Cavity Enhanced Absorption Spectroscopy with Optical Feedback
2013 • 34 citations
Quantum cascade laser-based sensors for the detection of exhaled carbon monoxide
2016 • 34 citations
Potential for noninvasive assessment of lung inhomogeneity using highly precise, highly time-resolved measurements of gas exchange
2017 • 33 citations
Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science
2005 • 32 citations
Portable optical spectroscopy for accurate analysis of ethane in exhaled breath
2007 • 32 citations
Ethylene, an early marker of systemic inflammation in humans
2017 • 32 citations
Portable Device for Measuring Breath Acetone Based on Sample Preconcentration and Cavity Enhanced Spectroscopy
2016 • 31 citations
Real-time monitoring of hydrogen cyanide (HCN) and ammonia (NH 3 ) emitted by Pseudomonas aeruginosa
2015 • 31 citations
The effect of a paced auditory serial addition test (PASAT) intervention on the profile of volatile organic compounds in human breath: a pilot study
2013 • 30 citations
Real-time monitoring of endogenous lipid peroxidation by exhaled ethylene in patients undergoing cardiac surgery
2014 • 30 citations
A fully integrated standalone portable cavity ringdown breath acetone analyzer
2015 • 30 citations
RF noise induced laser perturbation for improving the performance of non-resonant cavity enhanced absorption spectroscopy
2014 • 27 citations
Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications
2013 • 27 citations
Mechanisms linking metabolism of Helicobacter pylori to 18O and 13C-isotopes of human breath CO2
2015 • 25 citations
Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy
2007 • 25 citations
Laser-based human breath analysis: D/H isotope ratio increase following heavy water intake
2009 • 24 citations
Clinical utility of breath ammonia for evaluation of ammonia physiology in healthy and cirrhotic adults
2015 • 24 citations
Absorption Properties of Simply Fabricated All-Metal Mushroom Plasmonic Metamaterials Incorporating Tube-Shaped Posts for Multi-Color Uncooled Infrared Image Sensor Applications
2016 • 24 citations
Real Time Ammonia Detection in Exhaled Human Breath with a Quantum Cascade Laser Based Sensor
2009 • 23 citations
The potential offered by real-time, high-sensitivity monitoring of ethane in breath and some pilot studies using optical spectroscopy
2005 • 23 citations
The level of ethylene biomarker in the renal failure of elderly patients analyzed by photoacoustic spectroscopy
2013 • 23 citations
Suspended GaN-based nanostructure for integrated optics
2016 • 23 citations
Mid-infrared continuous-filtering Vernier spectroscopy using a doubly resonant optical parametric oscillator
2017 • 22 citations
A compact laser-based spectrometer for detection of C2H2 in exhaled breath and HCN in vitro
2014 • 22 citations
Optical-feedback cavity-enhanced absorption spectroscopy with an interband cascade laser: application to SO2 trace analysis
2016 • 22 citations
Oxygen-18 stable isotope of exhaled breath CO2as a non-invasive marker of Helicobacter pylori infection
2014 • 21 citations
Laser-Based Method and Sample Handling Protocol for Measuring Breath Acetone
2014 • 21 citations
Influence of Ethanol on Breath Acetone Measurements Using an External Cavity Quantum Cascade Laser
2016 • 21 citations
Detection of hydrogen cyanide from oral anaerobes by cavity ring down spectroscopy
2016 • 20 citations
Measuring and imaging nanomechanical motion with laser light
2016 • 20 citations
Enhancing the sensitivity of mid-IR quantum cascade laser-based cavity-enhanced absorption spectroscopy using RF current perturbation
2014 • 20 citations
Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise?
2013 • 19 citations
A broadband Tm/Ho-doped fiber laser tunable from 1.8 to 2.09 µm for intracavity absorption spectroscopy
2018 • 18 citations
A mechanistic physicochemical model of carbon dioxide transport in blood
2016 • 18 citations
Influence of age and sex in exhaled breath samples investigated by means of infrared laser absorption spectroscopy
2011 • 16 citations
Comparison of optical-feedback cavity-enhanced absorption spectroscopy and gas chromatography for ground-based and airborne measurements of atmospheric CO concentration
2017 • 16 citations
ICL-Based OF-CEAS: A Sensitive Tool for Analytical Chemistry
2016 • 14 citations
Hydrogen cyanide in the headspace of oral fluid and in mouth-exhaled breath
2014 • 14 citations
Lipid peroxidation in cardiac surgery: towards consensus on biomonitoring, diagnostic tools and therapeutic implementation
2017 • 13 citations
Pulmonary infection, and not systemic inflammation, accounts for increased concentrations of exhaled nitric oxide in patients with septic shock
2013 • 11 citations
Real-time measurements of endogenous carbon monoxide production in isolated pig lungs
2014 • 10 citations
Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study
2012 • 10 citations
Changes in the concentration of breath ammonia in response to exercise: a preliminary investigation
2014 • 9 citations
Point-of-care companion diagnostic tests for personalizing psychiatric medications: fulfilling an unmet clinical need
2017 • 7 citations
Exhaled carbon monoxide is correlated with ischemia reperfusion injuries during ex vivo lung perfusion in pigs
2017 • 6 citations
Energy-tunable single-photon light-emitting diode by strain fields
2016 • 6 citations
Human Breath Acetone Analysis by Mid-IR Laser Spectroscopy: Development and Application
2018 • 6 citations
Octave-spanning dual comb spectroscopy in the molecular fingerprint region
2018 • 4 citations
Towards the full frequency stabilization of quantum cascade laser frequency combs
2017 • 3 citations
補償型強磁性体における調整可能なマグノン-光子結合: 弱結合から強結合へ
2017 • 1 citations
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