Studies of hypoxemic/reoxygenation injury: Without aortic clamping

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

The ventricular pressure-volume diagram revisited.

1978 • 479 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass

1990 • 251 citations

Inadequate myocardial protection with cold cardioplegic arrest during repair of tetralogy of Fallot

1988 • 133 citations

Intracardiac surgery in infants under age 3 months: Incremental risk factors for hospital mortality

1981 • 130 citations

Oxygen free radical generation during cardiopulmonary bypass: correlation with complement activation.

1986 • 114 citations

Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot.

1987 • 112 citations

Effect of hypoxia on myocardial high-energy phosphates in the neonatal mammalian heart

1978 • 107 citations

Chronic Hypoxemia Depresses Global Ventricular Function and Predisposes to the Depletion of High-Energy Phosphates during Cardioplegic Arrest: Implications for Surgical Repair of Cyanotic Congenital Heart Defects

1984 • 107 citations

Cardiac stun in infants undergoing extracorporeal membrane oxygenation

1991 • 93 citations

Effect of oxygen tension and cardiovascular operations on the myocardial antioxidant enzyme activities in patients with tetralogy of Fallot and aorta-coronary bypass

1992 • 93 citations

Free radical scavengers in myocardial ischemia.

1987 • 91 citations

Severe myocardial dysfunction during extracorporeal membrane oxygenation

1992 • 90 citations

Myocardial protection in cyanotic neonatal lambs

1988 • 83 citations

Studies of controlled reperfusion after ischemia. XXI. Reperfusate composition: superiority of blood cardioplegia over crystalloid cardioplegia in limiting reperfusion damage--importance of endogenous oxygen free radical scavengers in red blood cells.

1991 • 78 citations

Studies of myocardial protection in the immature heart

1991 • 77 citations

Studies of controlled reperfusion after ischemia

1991 • 65 citations

Superoxide Dismutase Therapy for Myocardial Ischemia

1991 • 63 citations

Effect of oxygen tension on the anti-oxidant enzyme activities of tetralogy of Fallot ventricular myocytes

1989 • 55 citations

Studies of myocardial protection in the immature heart. II. Evidence for importance of amino acid metabolism in tolerance to ischemia.

1990 • 54 citations

The End-Systolic Pressure-Volume Relationship in the Newborn Lamb: Effects of Loading and Inotropic Interventions

1991 • 53 citations

Altered antioxidant status in the ischemic/reperfused rabbit myocardium: effects of allopurinol.

1989 • 51 citations

Studies of myocardial protection in the immature heart

1990 • 44 citations

Superoxide dismutase decreases early reperfusion release of conjugated dienes following regional canine ischemia

1989 • 43 citations

Oxidative injury in reoxygenated and reperfused hearts☆

1994 • 35 citations

Enzyme release and mitochondrial activity in reoxygenated cardiac muscle: relationship with oxygen-induced lipid peroxidation.

1989 • 32 citations

Developmental changes in reperfusion injury

1988 • 32 citations

Neutrophils delay functional recovery of the post-hypoxic heart of the rabbit.

1989 • 30 citations

Cardiopulmonary dysfunction produced by reoxygenation of immature hypoxemic animals supported by cardiopulmonary bypass Prevention by intravenous metabolic pretreatment

1993 • 24 citations

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