Self-Splicing RNA: Implications for Evolution

Catalysis in chemistry and enzymology

1969 • 3,236 citations

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1983 • 2,604 citations

Why genes in pieces?

1978 • 2,256 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

The origin of the genetic code

1968 • 2,226 citations

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

1981 • 877 citations

Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members.

1983 • 510 citations

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

1982 • 501 citations

Coenzymes as fossils of an earlier metabolic state

1976 • 485 citations

Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron

1980 • 477 citations

Making ends meet: a model for RNA splicing in fungal mitochondria

1982 • 459 citations

Secondary Structure of 16 S Ribosomal RNA

1981 • 446 citations

Complete nucleotide sequence of a 23S ribosomal RNA gene from Escherichia coli.

1980 • 401 citations

Direct repeats flank three small nuclear RNA pseudogenes in the human genome

1981 • 307 citations

The Pyridine Nucleotide Coenzymes

1982 • 294 citations

Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage–ligation reaction

1983 • 287 citations

Catalytic Activity of an RNA Molecule Prepared by Transcription in Vitro

1984 • 274 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences.

1983 • 251 citations

Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing

1982 • 235 citations

Critical sequences within mitochondrial introns: Pleiotropic mRNA maturase and cis-dominant signals of the box intron controlling reductase and oxidase

1982 • 234 citations

Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNAPhe—implications for lead toxicity and self-splicing RNA

1983 • 225 citations

The macronuclear ribosomal DNA of Tetrahymena pyriformis is a palindrome

1976 • 224 citations

Anatomy of the chloroplast ribosomal DNA of chlamydomonas reinhardii

1978 • 203 citations

Rearranged mitochondrial genes in the yeast nuclear genome

1983 • 196 citations

Intron within the large rRNA gene of N. crassa mitochondria: A long open reading frame and a consensus sequence possibly important in splicing

1982 • 190 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNA

1984 • 171 citations

A single integrated gene for ribosomal RNA in a eucaryote, tetrahymena pyriformis

1977 • 167 citations

An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA

1978 • 162 citations

Free ribosomal DNA molecules from Tetrahymena pyriformis GL are giant palindromes

1976 • 162 citations

Free Ribosomal RNA Genes in the Macronucleus of Tetrahymena

1974 • 160 citations

Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance

1981 • 154 citations

The yeast tRNATyr gene intron is essential for correct modification of its tRNA product

1983 • 152 citations

Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.

1982 • 147 citations

An intervening sequence in the gene coding for 25S Ribosomal RNA of Tetrahymena pigmentosa

1979 • 143 citations

Nucleotide sequence ofAspergillus nidulansmitochondrial genes coding for ATPase subunit 6, cytochrome oxidase subunit 3, seven unidentified proteins, four tRNAs and L-rRNA

1982 • 135 citations

E. coli RNAase P has a required RNA component in vivo

1980 • 121 citations

Identification of two erythromycin resistance mutations in the mitochondrial gene coding for the large ribosomal RNA in yeast

1982 • 118 citations

In vitro splicing of the ribosomal RNA precursor in nuclei of tetrahymena

1980 • 115 citations

Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus pupuratus

1983 • 109 citations

Close relationship between certain nuclear and mitochondrial introns

1983 • 109 citations

Integration of mitochondrial gene sequences within the nuclear genome during senescence in a fungus

1983 • 107 citations

The fate of an intervening sequence RNA: Excision and cyclization of the Tetrahymena ribosomal RNA intervening sequence in vivo

1983 • 102 citations

Internal structure of a mitochondrial intron of Aspergillus nidulans.

1982 • 91 citations

Identification and cloning of a yeast nuclear gene (CBP1) involved in expression of mitochondrial cytochrome b.

1982 • 77 citations

Lead Ion Binding and RNA Chain Hydrolysis in Phenylalanine tRNA

1983 • 77 citations

Defective splicing of mitochondrial rRNA in cytochrome-deficient nuclear mutants of Neurospora crassa.

1979 • 74 citations

A proton-coupled conformational switch of Escherichia coli 5S ribosomal RNA.

1980 • 73 citations

Extrachromosomal ribosomal RNA genes in Tetrahymena structure and evolution

1979 • 70 citations

Allele-specific, selective amplification of a ribosomal RNA gene in tetrahymena thermophila

1982 • 69 citations

Mutations within an intron and its flanking sites: Patterns of novel polypeptides generated by mutants in one segment of the cob-box region of yeast mitochondrial DNA

1980 • 69 citations

Processing of yeast mitochondrial RNA: Involvement of intramolecular hybrids in splicing of cob intron 4 RNA by mutation and reversion

1983 • 67 citations

Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping.

1979 • 66 citations

Autonomous rDNA molecules containing single copies of the ribosomal RNA genes in the macronucleus of Tetrahymena pyriformis

1974 • 65 citations

The intervening sequence in the 26s rrna coding region of t. thermophila is transcribed within the largest stable precursor for rRNA

1979 • 61 citations

RNA splicing and polynucleotide evolution

1979 • 56 citations

Expression of the “split gene” COB in yeast mtDNA. Translation of intervening sequences in mutant strains.

1981 • 51 citations

Antibodies against a fused ‘lacZ-yeast mitochondrial intron’ gene product allow identification of the mRNA maturase encoded by the fourth intron of the yeast cob-box gene.

1984 • 45 citations

RNA splicing in neurospora mitochondria: Structure of the unspliced 35S precursor ribosomal RNA detected by psoralen cross-linking

1983 • 36 citations

Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA

1980 • 34 citations

Processing of ribosomal precursor RNAs in Physarum polycephalum

1980 • 25 citations

In vitro splicing of the ribosomal RNA precursor in isolated nucleoli from Tetrahymena

1980 • 24 citations

Science and the Citizen

1981 • 3 citations