Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

Translational control by 5′-untranslated regions of eukaryotic mRNAs

2016 • 955 citations

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A

2006 • 351 citations

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

2015 • 327 citations

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

2009 • 281 citations

Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation

2014 • 172 citations

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

2009 • 166 citations

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

2014 • 151 citations

Ebola Virus VP30-Mediated Transcription Is Regulated by RNA Secondary Structure Formation

2002 • 150 citations

Regulation Mechanisms of Viral IRES-Driven Translation

2017 • 141 citations

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

2013 • 117 citations

Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

2014 • 116 citations

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

2011 • 110 citations

Coronavirus cis-Acting RNA Elements

2016 • 109 citations

Processing of the Human Coronavirus 229E Replicase Polyproteins by the Virus-Encoded 3C-Like Proteinase: Identification of Proteolytic Products and Cleavage Sites Common to pp1a and pp1ab

1999 • 103 citations

The natural compound silvestrol is a potent inhibitor of Ebola virus replication

2016 • 95 citations

The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen‐activated protein kinase activities

2007 • 93 citations

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

2016 • 91 citations

Activity-guided isolation of cytotoxic constituents from the bark of Aglaia crassinervia collected in Indonesia

2005 • 66 citations

Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

2013 • 62 citations

Tricks an IRES uses to enslave ribosomes

2012 • 55 citations

Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

2011 • 47 citations

RNA binding specificity of Ebola virus transcription factor VP30

2016 • 33 citations

The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease

2014 • 27 citations

D, L-lysine acetylsalicylate + glycine Impairs Coronavirus Replication

2016 • 24 citations