Amino acids as volume-regulatory osmolytes in mammalian cells

Living with Water Stress: Evolution of Osmolyte Systems

1982 • 3,735 citations

Role of amino acid transport and countertransport in nutrition and metabolism.

1990 • 1,101 citations

Biochemistry and physiology of taurine and taurine derivatives.

1968 • 1,038 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Osmotic Demyelination Syndrome Following Correction of Hyponatremia

1986 • 757 citations

Regulation of cellular volume.

1977 • 607 citations

TAURINE: BIOLOGICAL UPDATE

1986 • 571 citations

Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes

1983 • 510 citations

Transport of ions and water in animals

1977 • 481 citations

Anisosmotic cell volume regulation: a comparative view

1989 • 394 citations

Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes

1979 • 386 citations

Predominant osmotically active organic solutes in rat and rabbit renal medullas.

1986 • 382 citations

Protons, osmolytes, and fitness of internal milieu for protein function

1986 • 340 citations

Effects on the central nervous system of hypernatremic and hyponatremic states

1976 • 320 citations

Mechanisms of osmoregulation in animals

1979 • 290 citations

Volume regulation in astrocytes: A role for taurine as an osmoeffector

1988 • 260 citations

Taurine: An Essential Nutrient for the Cat

1978 • 250 citations

Untersuchungen zum Problem der Harnkonzentrierung und Harnverd�nnung

1956 • 246 citations

Methylamine osmoregulatory solutes of elasmobranch fishes counteract urea inhibition of enzymes

1980 • 245 citations

A Possible Role for Taurine in Osmoregulation Within the Brain

1988 • 223 citations

Taurine: A role in osmotic regulation of mammalian brain and possible clinical significance

1980 • 205 citations

Solute compatibility with enzyme function and structure: Rationales for the selection of osmotic agents and end‐products of anaerobic metabolism in marine invertebrates

1979 • 197 citations

Activation of ion transport systems during cell volume regulation

1987 • 195 citations

Permeability of blood-brain barrier to various sized molecules

1985 • 188 citations

Brain dehydration and neurologic deterioration after rapid correction of hyponatremia

1989 • 172 citations

GABA, glycine, aspartate, glutamate and taurine in the vestibular nuclei: an immunocytochemical investigation in the cat

1990 • 169 citations

Adaptation to chronic hypoosmolality in rats

1988 • 169 citations

COMPARATIVE PHYSIOLOGY OF SWEATING

2006 • 168 citations

Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pH_i in the Rat Brain In Vivo: Detection by Sequential ¹H and ³¹P NMR Spectroscopy

1985 • 156 citations

Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids

1989 • 154 citations

Abnormalities of cell volume regulation and their functional consequences

1980 • 145 citations

Towards a unifying theory for the actions of taurine

1986 • 144 citations

Characterization of the major brain osmolytes that accumulate in salt-loaded rats

1989 • 138 citations

Release of taurine from astrocytes during potassium‐evoked swelling

1989 • 134 citations

High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells.

1979 • 133 citations

Disturbances in Body Fluid Osmolality.

1977 • 131 citations

Taurine and Osmoregulation: Taurine Is a Cerebral Osmoprotective Molecule in Chronic Hypernatremic Dehydration

1988 • 128 citations

Signal for induction of aldose reductase in renal medullary cells by high external NaCl

1989 • 128 citations

Hypernatremic (Hypertonic) Dehydration in Infants

1973 • 127 citations

Amino acid transport and cell volume regulation in Ehrlich ascites tumour cells.

1983 • 125 citations

myo-Inositol: A Newly Identified Nonnitrogenous Osmoregulatory Molecule in Mammalian Brain

1989 • 120 citations

Survey of osmolytes in renal cell lines

1988 • 119 citations

Changes with aging in the levels of amino acids in rat CNS structural elements II. Taurine and small neutral amino acids

1989 • 119 citations

Principles of Cell Volume Regulation

1988 • 110 citations

[Studies on the problem of urine concentration and dilution; distribution of electrolytes (sodium, potassium, calcium, magnesium, anorganic phosphate), urea amino acids and exogenous creatinine in the cortex and medulla of dog kidney in various diuretic conditions].

1956 • 106 citations

ENCEPHALOPATHY AND MYELINOLYSIS AFTER RAPID CORRECTION OF HYPONATRAEMIA

1987 • 106 citations

Counteracting effects of urea and betaine in mammalian cells in culture

1990 • 104 citations

Taurine: Possible Role in Osmotic Regulation of Mammalian Heart

1981 • 102 citations

The identification of neutral amino acid transport systems

1990 • 101 citations

Effect of anisotonic media on volume, ion and amino-acid content and membrane potential of kidney cells (MDCK) in culture

1987 • 98 citations

The time-course of changes in renal tissue composition during lysine vasopressin infusion in the rat

1969 • 98 citations

Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux

1988 • 98 citations

Regulation of brain water and electrolytes during acute hyperosmolality in rats

1987 • 96 citations

Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis

1989 • 93 citations

The role of amino acids and taurine in isosmotic intracellular regulation in Ehrlich ascites mouse tumour cells

1976 • 91 citations

Volume Regulation in Cells of Euryhaline Invertebrates

1987 • 88 citations

Volume-regulatory K+ efflux during concentrative uptake of alanine in isolated rat hepatocytes

1984 • 84 citations

Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: Rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain

1987 • 82 citations

Elevation of rat brain amino acids, ammonia and idiogenic osmoles induced by hyperosmolality

1979 • 80 citations

Ion Channels and Cell Volume Regulation: Chaos in an Organized System

1990 • 78 citations

Characterization and purification of a mammalian osmoregulatory protein, aldose reductase, induced in renal medullary cells by high extracellular NaCl.

1987 • 77 citations

Sodium-coupled glycine uptake by Ehrlich ascites tumor cells results in an increase in cell volume and plasma membrane channel activities.

1988 • 75 citations

Volume-activated K+ and Cl- pathways of dissociated epithelial cells (MDCK): role of Ca2+

1990 • 69 citations

Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney

1988 • 69 citations

Osmotically active organic solutes in the renal inner medulla

1987 • 68 citations

Evaluation of the osmoregulatory function of taurine in brain cells

1987 • 67 citations

Regulation of organic osmolyte concentrations in tubules from rat renal inner medulla

1989 • 67 citations

Effects of changes in serum osmolarity on bulk flow of fluid into cerebral ventricles and on brain water content

1975 • 62 citations

Cell volume regulation in flounder (Platichthys flesus) heart muscle accompanying an alteration in plasma osmolality

1975 • 61 citations

Adaptive regulation of taurine transport in two continuous renal epithelial cell lines

1990 • 57 citations

Osmoregulation of renal papillary cells

1985 • 56 citations

Sodium ion movements and the spontaneous and electrically stimulated release of [3H]GABA and [14C]glutamic acid from rat cortical slices

1972 • 56 citations

Calcium regulation by the low-affinity taurine binding sites of cardiac sarcolemma.

1980 • 54 citations

Sodium-coupled amino acid transport in renal tubule

1989 • 53 citations

EFFECTS OF SALT AND WATER LOADING ON CARBOHYDRATE AND ENERGY METABOLISM AND LEVELS OF SELECTED AMINO ACIDS IN THE BRAINS OF YOUNG MICE¹

1975 • 53 citations

Effects of osmotic shocks on the ultrastructure of different tissues and cell types

1985 • 52 citations

Accumulation of major organic osmolytes in rat renal inner medulla in dehydration

1988 • 49 citations

Brain taurine content as a function of cerebral metabolic rate: Osmotic regulation of glucose derived water production

1989 • 47 citations

Mechanisms in Volume Regulation in Ehrlich Ascites Tumor Cells

1988 • 46 citations

Regulation of the Predominant Renal Medullary Organic Solutes In Vivo

1990 • 45 citations

Amino acid transport by juxtamedullary nephrons: distal reabsorption and recycling

1988 • 44 citations

Taurine transport by rabbit kidney brush-border membranes: Coupling to sodium, chloride, and the membrane potential

1988 • 44 citations

Release of Endogenous Taurine and γ‐Aminobutyric Acid from Brain Slices from the Adult and Developing Mouse

1989 • 41 citations

CHARACTERIZATION OF TAURINE UPTAKE BY NEURONAL AND GLIAL CELLS IN CULTURE

1979 • 40 citations

Rapid hypertonic cell volume regulation in the perfused inner medullary collecting duct

1989 • 40 citations

High-affinity uptake of taurine and ?-alanine in primary cultures of rat astrocytes

1986 • 39 citations

Effect of Chronic Hypernatremic Dehydration and Rapid Rehydration on Brain Carbohydrate, Energy, and Amino Acid Metabolism in Weanling Mice

1983 • 37 citations

In vitro osmoregulation of taurine in fetal mouse hearts*

1984 • 36 citations

Are ninhydrin‐positive substances volume‐regulatory osmolytes in rat renal papillary cells?

1987 • 36 citations

Cell Volume Regulation in Renal Cortical Cells

1988 • 35 citations

How Do Sodium-Absorbing Cells Do Their Job and Survive?

1986 • 35 citations

Role of Amino Acid Transport System A in the Control of Cell Volume in Cultured Human Fibroblasts

1991 • 35 citations

Effects of Pregnancy on the Contents of Water, Taurine, and Total Amino Nitrogen in Rat Cerebral Cortex

1989 • 34 citations

Mutual interactions in the transport of taurine, hypotaurine, and GABA in brain slices

1983 • 33 citations

Rapid Correction of Hyponatraemia with Urea may Protect against Brain Damage in Rats

1989 • 32 citations

Activation of γ‐glutamyl transpeptidase by monovalent cations

1973 • 30 citations

Effects of inorganic salts and of ouabain on some metabolic responses of rat cerebral cortex slices to cationic and electrical stimulations

1968 • 29 citations

Neutral Amino Acid Transport in Astrocytes: Characterization of Na⁺‐Dependent and Na⁺‐Independent Components of α‐Aminoisobutyric Acid Uptake

1988 • 28 citations

Volume Preservation: Then and Now

1989 • 28 citations

Alanine stimulation of passive potassium efflux in hepatocytes is independent of Na(+)-K+ pump activity

1990 • 28 citations

Free myo-Inositol in Canine Kidneys: Selective Concentration in the Renal Medulla

1982 • 28 citations

Weak organic acids induce taurine release through an osmotic‐sensitive process in in vivo rat hippocampus

1990 • 26 citations

Differential effects of hypertonic mannitol and glycerol on rat brain metabolism and amino acids

1981 • 25 citations

Acute regulation of the predominant organic solutes of the rabbit renal inner medulla

1989 • 24 citations

Organic osmolytes in inner medulla of Brattleboro rat: effects of ADH and dehydration

1989 • 24 citations

Renal transport of neutral amino acids. Cation-dependent uptake of <scp>l</scp>-alanine by luminal-membrane vesicles

1987 • 22 citations

Cell Volume Control: Fundamental and Comparative Aspects in Animal Cells

1987 • 22 citations

The osmoregulatory function of taurine and glutamic acid.

1985 • 22 citations

Influence of variations in hydration and in solute excretion on the effects of lysine‐vasopressin infusion on urinary and renal tissue composition in the conscious rat

1971 • 21 citations

Sorbitol metabolism in inner medullary collecting duct cells of diabetic rats

1989 • 21 citations

The volume and ionic composition of cells in incubated slices of rat renal cortex, medulla and papilla

1987 • 20 citations

Effect of antidiuretic hormone on renal organic osmolytes in Brattleboro rats

1989 • 18 citations

Society for Pediatric Research Presidential Address New Functions for an Old Molecule

1987 • 17 citations

Amino acid content in astroglial primary cultures from different brain regions during cultivation

1987 • 17 citations

Intra-renal distribution of free amino acids in antidiuretic ruminants

1966 • 16 citations

Energetics of Na+-dependent amino acid co-transport in Ehrlich ascites tumor cells

1987 • 14 citations

Effect of a hypo-osmotic shock on the volume and the ion content of rat kidney cortex slices

1980 • 14 citations

Volume regulation in renal epithelial cells.

1987 • 13 citations

An inwardly-directed sodium-amino acid cotransporter influences steady-state cell volume in slices of rat renal papilla incubated in hyperosmotic media

1988 • 13 citations

Non-Donnan Effects of Organic Osmolytes in Cell Volume Changes

1987 • 12 citations

Element composition of tubule cells in the inner stripe of the renal outer medulla.

1989 • 10 citations

The Physiology of the Renal Tract in Pregnancy

1985 • 9 citations

Taurine uptake in atrial myocardium by a sodium-dependent β-amino acid system in the elasmobranch, Raja erinacea

1980 • 8 citations

Organic Solute Profiles and Transport in the Rat Renal Medulla

1989 • 8 citations

Lability of renal papillary tissue composition in the rat.

1978 • 8 citations

Adaptation to hyperosmolality in the rat

1980 • 7 citations

The effect of hyperosmolal urea on the transport of amino acids into rat brain

1976 • 6 citations

Deleted Work

1955 • 0 citations