Chapter 26 Neurotransmitters and cytokines in CNS pathology

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Handbook of clinical neurology

1986 • 1,951 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death

1992 • 939 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Intercellular signaling in glial cells: Calcium waves and oscillations in response to mechanical stimulation and glutamate

1991 • 723 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

1987 • 450 citations

Mast cell heterogeneity: effects of neuroenteric peptides on histamine release.

1985 • 440 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Tumor Necrosis Factor and Granulocyte Macrophage-Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium avium and to Kill Avirulent M. avium: Killing Effector Mechanism Depends on the Generation of Reactive Nitrogen Intermediates

1991 • 390 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Modulation of cytokine production by transforming growth factor-beta.

1989 • 331 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Enhancement of phagocytosis — A newly found activity of Substance P residing in its N-terminal tetrapeptide sequence

1980 • 312 citations

Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.

1988 • 281 citations

Substance P: binding properties and studies on cellular responses in guinea pig macrophages.

1986 • 262 citations

Substance P recognition by a subset of human T lymphocytes.

1984 • 258 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.

1990 • 229 citations

Substance P receptor-mediated chemotaxis of human monocytes

1985 • 222 citations

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK ₁ ) Receptor Antagonist

1991 • 221 citations

Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis

1983 • 216 citations

New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury

1990 • 213 citations

Effects of Interleukin-1 and Tumor Necrosis Factor-α on Astrocytes, Microglia, Oligodendrocytes, and Glial Precursors in vitro

1991 • 209 citations

Production of nitrite by neonatal rat microglial cells/ brain macrophages

1992 • 198 citations

Receptors for Substance P and Related Neurokinins

1989 • 187 citations

Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from l-arginine by macrophages and hepatocytes

1990 • 183 citations

Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients

1985 • 169 citations

Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin

1993 • 163 citations

The Neuropeptide Substance P Stimulates Production of Interleukin 1 in Human Blood Monocytes: Activated Cells are Preferentially Influenced by the Neuropeptide

1990 • 152 citations

Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages.

1987 • 150 citations

Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.

1986 • 127 citations

Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.

1988 • 126 citations

Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGFβ

1991 • 126 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium.

1990 • 112 citations

Cytokine-induced enhancement of ICAM-1 expression results in increased vulnerability of tumor cells to monocyte-mediated lysis.

1991 • 103 citations

Platelet activating factor raises intracellular calcium ion concentration in macrophages.

1986 • 101 citations

Substance P stimulates IL-1 production by astrocytes via intracellular calcium

1992 • 101 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Multiple tachykinin binding sites in hamster, rat and guinea-pig urinary bladder

1986 • 99 citations

Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism

1988 • 98 citations

Substance P receptors in primary cultures of cortical astrocytes from the mouse.

1986 • 97 citations

In vitro study of mediators of inflammation in multiple sclerosis

1989 • 91 citations

Production of interleukin-1 by microglia in response to substance P: role for a non-classical NK-1 receptor

1993 • 90 citations

Action site of circulating interleukin-1 on the rabbit brain

1991 • 89 citations

Neuropeptides Modulating Macrophage Function

1987 • 89 citations

Substance P and vasoactive intestinal peptide in bullous and inflammatory skin disease

1986 • 81 citations

Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes.

1986 • 72 citations

Cell surface tumor necrosis factor (TNF) accounts for monocyte- and lymphocyte-mediated killing of TNF-resistant target cells

1989 • 67 citations

Substance P immunoreactive astrocytes are present in multiple sclerosis plaques

1989 • 60 citations

Pharmacological characterisation of two tachykinin binding sites in the rat cerebral cortex

1985 • 48 citations

Substance-P-like levels in inflammatory exudates

1988 • 46 citations

Binding of a Iodinated Substance P Analog to a NK-1 Receptor on Isolated Cell Membranes from Rat Anterior Pituitary*

1989 • 41 citations

Activation of substance P receptors leads to membrane potential responses in cultured astrocytes

1989 • 39 citations

Calcium ionophore A23187 does not stimulate lipopolysaccharide nonresponsive C3H/HeJ peritoneal macrophages to produce interleukin 1.

1987 • 36 citations

An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes

1986 • 32 citations

Possible Role of H<sub>2</sub>O<sub>2</sub>-Mediated Complement Activation and Cytokines-Mediated Fibroblasts Superoxide Generation on Skin Inflammation

1989 • 18 citations

Autoimmune disease and the nervous system. Biochemical, molecular, and clinical update.

1992 • 15 citations