Leukocytes as secretory organs of inflammation

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE

1966 • 6,585 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Colchicine-binding protein of mammalian brain and its relation to microtubules

1968 • 1,140 citations

THE MECHANISM OF ACTION OF COLCHICINE

1967 • 1,049 citations

Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.

1968 • 742 citations

Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum.

1956 • 669 citations

Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins

1971 • 614 citations

The effect of epinephrine on immunoreactive insulin levels in man.

1966 • 550 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

1972 • 462 citations

Histamine Release in vitro: Inhibition by Catecholamines and Methylxanthines

1968 • 458 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

Human lymphocyte metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin

1971 • 393 citations

“The Role of Cyclic 3′, 5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes”

1972 • 388 citations

Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes

1972 • 381 citations

Effect of Cyclic AMP on Release of Lysosomal Enzymes from Phagocytes

1971 • 380 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM HUMAN LEUKOCYTES

1973 • 346 citations

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

1971 • 338 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

The Role of Cyclic 3′,5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes

1972 • 305 citations

IMMUNITY IN INFECTIVE DISEASES

1906 • 282 citations

Cyclic Nucleotide-dependent Protein Kinases

1972 • 282 citations

Immunity in infective diseases

1905 • 252 citations

Cytochalasin B: Effect on Lysosomal Enzyme Release from Human Leukocytes

1973 • 243 citations

STUDIES ON LYSOSOMES

1968 • 238 citations

Leukocytic proteases and the immunologic release of lysosomal enzymes.

1972 • 197 citations

Histamine Augments Leukocyte Adenosine 3′,5′-Monophosphate and Blocks Antigenic Histamine Release

1971 • 188 citations

Microtubule Crystals: A New Biophysical Phenomenon induced by Vinca Alkaloids

1968 • 183 citations

Histamine release from human leukocytes: studies with deuterium oxide, colchicine, and cytochalasin B

1972 • 182 citations

Pathologic mechanisms in neutrophil-mediated injury.

1972 • 180 citations

Cyclic 3′,5′-adenosine monophosphate in the human leukocyte: synthesis, degradation, and effects on neutrophil candidacidal activity

1971 • 176 citations

Vibrio cholerae enterotoxin and its mode of action

1971 • 162 citations

Effect of Cyclic 3',5'-Adenosine Monophosphate and Theophylline on Lymphocyte Transformation

1970 • 157 citations

Alteration of the Cytotoxic Action of Sensitized Lymphocytes by Cholinergic Agents and Activators of Adenylate Cyclase

1972 • 143 citations

Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors.

1971 • 130 citations

Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. II. Influence of cellular levels of cyclic AMP.

1971 • 118 citations

Effects of Cholera Enterotoxin on Adenosine 3′,5′-Monophosphate and Neutrophil Function. COMPARISON WITH OTHER COMPOUNDS WHICH STIMULATE LEUKOCYTE ADENYL CYCLASE

1973 • 103 citations

The Role of Lysosomes in Immune Responses

1970 • 98 citations

Receptors for Histamine Can Be Detected on the Surface of Selected Leukocytes

1972 • 97 citations

Brief Note: Effects of Prostaglandins, Epinephrine and NaF on Human Leukocyte, Platelet and Liver Adenyl Cyclase

1970 • 84 citations

Mobilization and extracellular release of granular enzymes from human leukocytes during phagocytosis: inhibition by colchicine and cortisol but not by salicylate

1973 • 81 citations

Enhancement of Immunologically Induced Granule Exocytosis from Neutrophils by Cytochalasin B

1973 • 74 citations

COLCHICINE BINDING IN TISSUE SLICES

1971 • 73 citations

The response of polymorphonuclear leukocytes to immune complexes in vitro.

1971 • 68 citations

Stabilizing effects of D₂O on the microtubular components and needle‐like form of heliozoan axopods: A pressure‐temperature analysis

1971 • 57 citations

The effect of polystyrene beads on cyclic 3′,5′-adenosine monophosphate concentration in leukocytes

1971 • 54 citations

Inhibition by colchicine of carbamylcholine induced glycoprotein secretion by the submaxillary gland. A possible mechanism of cholinergic induced protein secretion

1972 • 51 citations

Neutrophilic Leukocytes in Immunologic Reactions in Vitro: Effect of Cytochalasin B

1973 • 43 citations

Cholera Enterotoxin: Failure of Anti-inflammatory Agents to Prevent Cyclic AMP Accumulation

1973 • 35 citations

Heavy Water Enhances IgE-Mediated Histamine Release from Human Leukocytes: Evidence for Microtubule Involvement

1972 • 31 citations

Sex hormones and acid gastric secretion induced with carbachol, histamine, and gastrin

1970 • 25 citations

Secretion from the bovine adrenal gland

1970 • 24 citations

Inosine 3′,5′-monophosphate and adenosine 3′,5′-monophosphate-dependent protein kinase from human PMN leucocytes

1972 • 22 citations